Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

Mapping of microvascular architecture in the brain of an Alzheimer's disease mouse model using MRI

(2021) Suk‐Ki Chang et al.   NMR IN BIOMEDICINE

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

(2020) Matthias Arnold et al.   Nature Communications

The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas

(2020) Quanxin Wang et al.   CELL

Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model

(2020) Yoichiro Abe et al.   Acta Neuropathologica Communications

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

(2020) Ying-Wooi Wan et al.   Cell Reports

In vivo Imaging With 18F-FDG- and 18F-Florbetaben-PET/MRI Detects Pathological Changes in the Brain of the Commonly Used 5XFAD Mouse Model of Alzheimer's Disease

(2020) Timon N. Franke et al.   Frontiers in Medicine

Analysis of Motor Function in the Tg4-42 Mouse Model of Alzheimer’s Disease

(2019) Jannek M. Wagner et al.   Frontiers in Behavioral Neuroscience

The “rights” of precision drug development for Alzheimer’s disease

(2019) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Frailty index and phenotype frailty score: Sex- and age-related differences in 5XFAD transgenic mouse model of Alzheimer’s disease

(2019) Smilja Todorovic et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The cost of Alzheimer's disease in China and re-estimation of costs worldwide

(2018) Jianping Jia et al.   Alzheimers & Dementia

Understanding the impact of sex and gender in Alzheimer's disease: A call to action

(2018) Rebecca A. Nebel et al.   Alzheimers & Dementia

Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer’s disease

(2018) T.P. O’Leary et al.   BEHAVIOURAL BRAIN RESEARCH

Systematic review of the efficacy of statins for the treatment of Alzheimer’s disease

(2018) Marta Mejías-Trueba et al.   CLINICAL MEDICINE

Different Cognitive Frailty Models and Health- and Cognitive-related Outcomes in Older Age: From Epidemiology to Prevention

(2018) Francesco Panza et al.   JOURNAL OF ALZHEIMERS DISEASE

The genes associated with early-onset Alzheimer’s disease

(2018) Meng-Hui Dai et al.   Oncotarget

Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer’s disease

(2018) Dongwha Sohn et al.   Scientific Reports

RNA-Seq Analysis of Frontal Cortex and Cerebellum from 5XFAD Mice at Early Stage of Disease Pathology

(2018) Kyung Hwa Kim et al.   JOURNAL OF ALZHEIMERS DISEASE

Evidence for Early Cognitive Impairment Related to Frontal Cortex in the 5XFAD Mouse Model of Alzheimer's Disease

(2018) Stéphane D. Girard et al.   JOURNAL OF ALZHEIMERS DISEASE

Whole brain imaging reveals distinct spatial patterns of amyloid beta deposition in three mouse models of Alzheimer's disease

(2018) Jennifer D. Whitesell et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A stereotaxic MRI template set of mouse brain with fine sub-anatomical delineations: Application to MEMRI studies of 5XFAD mice

(2018) Binbin Nie et al.   MAGNETIC RESONANCE IMAGING

Sex Differences in Blood HDL-c, the Total Cholesterol/HDL-c Ratio, and Palmitoleic Acid are Not Associated with Variants in Common Candidate Genes

(2017) Shannon L. Klingel et al.   LIPIDS

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Practical considerations for choosing a mouse model of Alzheimer’s disease

(2017) Joanna L. Jankowsky et al.   Molecular Neurodegeneration

Performance of Male and Female C57BL/6J Mice on Motor and Cognitive Tasks Commonly Used in Pre-Clinical Traumatic Brain Injury Research

(2016) Laura B. Tucker et al.   JOURNAL OF NEUROTRAUMA

Spatial learning and memory impairments are associated with increased neuronal activity in 5XFAD mouse as measured by manganese-enhanced magnetic resonance imaging

(2016) Xiang Tang et al.   Oncotarget

Amyloid and tau pathology of familial Alzheimer’s disease APP/PS1 mouse model in a senescence phenotype background (SAMP8)

(2015) D. Porquet et al.   AGE

Neuroinformatics of the Allen Mouse Brain Connectivity Atlas

(2015) Leonard Kuan et al.   METHODS

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease

(2015) Elizabeta Gjoneska et al.   NATURE

Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer’s Disease

(2015) Magdalena Elisabeth Siwek et al.   NEURAL PLASTICITY

Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse

(2014) I.R. Macdonald et al.   Current Alzheimer Research

Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics

(2014) T. J. Flanigan et al.   GENES BRAIN AND BEHAVIOR

Identifying Common Characteristics of Frailty Across Seven Scales

(2014) Olga Theou et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

A mesoscale connectome of the mouse brain

(2014) Seung Wook Oh et al.   NATURE

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Behavioral and EEG changes in male 5xFAD mice

(2014) F. Schneider et al.   PHYSIOLOGY & BEHAVIOR

Animal models of Alzheimer disease: historical pitfalls and a path forward

(2014) Sarah E. Cavanaugh   ALTEX-Alternatives to Animal Experimentation

Age-related deficit accumulation and the risk of late-life dementia

(2014) Xiaowei Song et al.   Alzheimers Research & Therapy

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Deciphering the Molecular Profile of Plaques, Memory Decline and Neuron Loss in Two Mouse Models for Alzheimer’s Disease by Deep Sequencing

(2014) Yvonne Bouter et al.   Frontiers in Aging Neuroscience

Frailty Consensus: A Call to Action

(2013) John E. Morley et al.   Journal of the American Medical Directors Association

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

Quantitative evaluation of MRI and histological characteristics of the 5xFAD Alzheimer mouse brain

(2013) N.G. Spencer et al.   NEUROIMAGE

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

The link between altered cholesterol metabolism and Alzheimer's disease

(2012) Paola Gamba et al.   Annals of the New York Academy of Sciences

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Reciprocal regulation of cholesterol and beta amyloid at the subcellular level in Alzheimer’s disease

(2012) Elena Posse de Chaves   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Neuronal Membranes are Key to the Pathogenesis of Alzheimers Disease: the Role of Both Raft and Non-Raft Membrane Domains

(2012) R. Williamson et al.   Current Alzheimer Research

Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease

(2012) Ling Li et al.   MOLECULAR NEUROBIOLOGY

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

(2012) M. Maulik et al.   MOLECULAR NEUROBIOLOGY

Serial two-photon tomography for automated ex vivo mouse brain imaging

(2012) Timothy Ragan et al.   NATURE METHODS

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Loss of motor function in preclinical Alzheimer’s disease

(2011) Aron S Buchman et al.   Expert Review of Neurotherapeutics

Nontraditional risk factors combine to predict Alzheimer disease and dementia

(2011) X. Song et al.   NEUROLOGY

GMP-compliant automated synthesis of [18F]AV-45 (Florbetapir F 18) for imaging β-amyloid plaques in human brain

(2010) Cheng-Hsiang Yao et al.   APPLIED RADIATION AND ISOTOPES

Lipid Membranes and β-Amyloid: A Harmful Connection

(2010) G.P. Eckert et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Late onset Alzheimer’s disease in older people

(2010) Ahmet Turan Isik   Clinical Interventions in Aging

Plasma Lipid Levels in the Elderly Are Not Associated with the Risk of Mild Cognitive Impairment

(2008) Christiane Reitz et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS