Deciphering the Molecular Profile of Plaques, Memory Decline and Neuron Loss in Two Mouse Models for Alzheimer’s Disease by Deep Sequencing

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

(2013) Yvonne Bouter et al.   ACTA NEUROPATHOLOGICA

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA

(2013) Ji-Woong Choi et al.   JOURNAL OF NEUROCHEMISTRY

Histone-Methyltransferase MLL2 (KMT2B) Is Required for Memory Formation in Mice

(2013) C. Kerimoglu et al.   JOURNAL OF NEUROSCIENCE

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Review: The genetics of Alzheimer's disease; putting flesh on the bones

(2013) C. Medway et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies

(2013) Lesley Cheng et al.   Frontiers in Genetics

The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice

(2013) Ajeet Rijal Upadhaya et al.   Acta Neuropathologica Communications

2012 Alzheimer’s disease facts and figures

(2012)   Alzheimers & Dementia

Structural Basis of β-Amyloid-Dependent Synaptic Dysfunctions

(2012) Christian Haupt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deregulated Cdk5 Activity Is Involved in Inducing Alzheimer’s Disease

(2012) Varsha Shukla et al.   ARCHIVES OF MEDICAL RESEARCH

Age-related changes in visual acuity, learning and memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease

(2012) Kurt R. Stover et al.   BEHAVIOURAL BRAIN RESEARCH

Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease

(2012) Yasushi Kishimoto et al.   BRAIN RESEARCH

Cathepsin B Degrades Amyloid-β in Mice Expressing Wild-type Human Amyloid Precursor Protein

(2012) Chao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

(2012) Jessica L. Wittnam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intraneuronal Aβ accumulation and neurodegeneration: Lessons from transgenic models

(2012) Oliver Wirths et al.   LIFE SCIENCES

The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and Therapy

(2012) Jin-Tai Yu et al.   MOLECULAR NEUROBIOLOGY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

(2012) Christine Vogel et al.   NATURE REVIEWS GENETICS

Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model

(2012) Kerstin T.S. Wirz et al.   NEUROBIOLOGY OF AGING

Motor Protein KIF1A Is Essential for Hippocampal Synaptogenesis and Learning Enhancement in an Enriched Environment

(2012) Makoto Kondo et al.   NEURON

GC-Content Normalization for RNA-Seq Data

(2011) Davide Risso et al.   BMC BIOINFORMATICS

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

(2011) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of metallobiology and amyloid-β peptides in Alzheimer’s disease

(2011) Blaine R. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

Transthyretin and the brain re-visited: Is neuronal synthesis of transthyretin protective in Alzheimer's disease?

(2011) Xinyi Li et al.   Molecular Neurodegeneration

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease

(2011) Antje Hillmann et al.   NEUROBIOLOGY OF AGING

Whole Transcriptome Sequencing Reveals Gene Expression and Splicing Differences in Brain Regions Affected by Alzheimer's Disease

(2011) Natalie A. Twine et al.   PLoS One

Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

(2011) Naoki Yahata et al.   PLoS One

Peptide Fingerprinting of Alzheimer's Disease in Cerebrospinal Fluid: Identification and Prospective Evaluation of New Synaptic Biomarkers

(2011) Holger Jahn et al.   PLoS One

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

(2010) Erik Portelius et al.   ACTA NEUROPATHOLOGICA

Replication of CLU, CR1, and PICALM Associations With Alzheimer Disease

(2010) Minerva M. Carrasquillo et al.   ARCHIVES OF NEUROLOGY

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

Distribution of VGF peptides in the human cortex and their selective changes in Parkinson’s and Alzheimer’s diseases

(2010) Cristina Cocco et al.   JOURNAL OF ANATOMY

Understanding the pathogenesis of Alzheimer’s disease: will RNA-Seq realize the promise of transcriptomics?

(2010) Greg T. Sutherland et al.   JOURNAL OF NEUROCHEMISTRY

Transcriptome profiling in neurodegenerative disease

(2010) Eliza Courtney et al.   JOURNAL OF NEUROSCIENCE METHODS

Defining the transcriptome and proteome in three functionally different human cell lines

(2010) Emma Lundberg et al.   Molecular Systems Biology

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease

(2010) Andreana C. Leskovjan et al.   NEUROIMAGE

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

Most “Dark Matter” Transcripts Are Associated With Known Genes

(2010) Harm van Bakel et al.   PLOS BIOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

(2009) Henning Breyhan et al.   ACTA NEUROPATHOLOGICA

Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

(2009) Vivian Y.H. Hook et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intraneuronal β-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice

(2009) Judit España et al.   BIOLOGICAL PSYCHIATRY

A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease

(2009) Sergey Kalinin et al.   Current Alzheimer Research

Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity

(2009) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis

(2009) M. Schuur et al.   NEUROBIOLOGY OF AGING

Failures to reconsolidate memory in a mouse model of Alzheimer’s disease

(2009) Masuo Ohno   NEUROBIOLOGY OF LEARNING AND MEMORY

A Serial Analysis of Gene Expression Profile of the Alzheimer’s Disease Tg2576 Mouse Model

(2009) Amee J. George et al.   NEUROTOXICITY RESEARCH

Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

(2008) Ditte Zerlang Christensen et al.   ACTA NEUROPATHOLOGICA

Neuropeptides in depression: Role of VGF

(2008) Smita Thakker-Varia et al.   BEHAVIOURAL BRAIN RESEARCH

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Intracellular Aβ triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease

(2008) Ditte Z. Christensen et al.   NEUROBIOLOGY OF AGING

Target Identification for CNS Diseases by Transcriptional Profiling

(2008) C Anthony Altar et al.   NEUROPSYCHOPHARMACOLOGY

The Transcriptional Landscape of the Yeast Genome Defined by RNA Sequencing

(2008) U. Nagalakshmi et al.   SCIENCE

A Global View of Gene Activity and Alternative Splicing by Deep Sequencing of the Human Transcriptome

(2008) M. Sultan et al.   SCIENCE

Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E

(2007) Simon P. Selwood et al.   NEUROBIOLOGY OF AGING