Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis
Published 2012 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis
Authors
Keywords
β-Amyloid peptide, Neurotoxicity, Lipid rafts, Neuronal cholesterol level/distribution
Journal
MOLECULAR NEUROBIOLOGY
Volume 47, Issue 1, Pages 37-63
Publisher
Springer Nature
Online
2012-09-15
DOI
10.1007/s12035-012-8337-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Regulation of Cerebral Cholesterol Metabolism in Alzheimer Disease
- (2016) Allison B. Reiss et al. JOURNAL OF INVESTIGATIVE MEDICINE
- Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking
- (2012) Stefan F. Lichtenthaler Current Alzheimer Research
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain
- (2012) Aarti N. Patel et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin
- (2012) Mahua Maulik et al. HUMAN MOLECULAR GENETICS
- -Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage
- (2012) A. Mohamed et al. JOURNAL OF NEUROSCIENCE
- Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer’s disease
- (2011) Andrey Y. Abramov et al. AGING CELL
- Amyloid Precursor Protein Processing and Alzheimer's Disease
- (2011) Richard J. O'Brien et al. Annual Review of Neuroscience
- Cholesterol Level and Statin Use in Alzheimer Disease
- (2011) Nina E. Shepardson ARCHIVES OF NEUROLOGY
- Genetics of Alzheimer's disease: new evidences for an old hypothesis?
- (2011) Jean-Charles Lambert et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis
- (2011) Catherine Marquer et al. FASEB JOURNAL
- Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization
- (2011) Vasiliki Michaki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease
- (2011) Robin B. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of Cleavage at β′-Site Contributes to Apparent Increase in β-Amyloid Peptide (Aβ) Secretion by β-Secretase (BACE1)-Glycosylphosphatidylinositol (GPI) Processing of Amyloid Precursor Protein
- (2011) Kulandaivelu S. Vetrivel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels
- (2011) C. Y. Daniel Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Localization of mature neprilysin in lipid rafts
- (2011) Kimihiko Sato et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Apolipoprotein E in Alzheimer's disease and other neurological disorders
- (2011) Philip B Verghese et al. LANCET NEUROLOGY
- Linking lipids to Alzheimer's disease: cholesterol and beyond
- (2011) Gilbert Di Paolo et al. NATURE REVIEWS NEUROSCIENCE
- Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-ß Peptide
- (2011) Konstantin Glebov et al. Neurodegenerative Diseases
- Association of Alzheimer disease pathology with abnormal lipid metabolism: The Hisayama Study
- (2011) T. Matsuzaki et al. NEUROLOGY
- Inhibition of β-amyloid1-42 internalization attenuates neuronal death by stabilizing the endosomal-lysosomal system in rat cortical cultured neurons
- (2011) M.S. Song et al. NEUROSCIENCE
- Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?
- (2010) Andrew J. Beel et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- ACAT inhibition and amyloid beta reduction
- (2010) Raja Bhattacharyya et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Brain cholesterol in normal and pathological aging
- (2010) Mauricio Martin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Role of amyloid beta in lipid homeostasis
- (2010) Sven Grösgen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Membrane rafts in Alzheimer's disease beta-amyloid production
- (2010) Kulandaivelu S. Vetrivel et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Aβ polymerization through interaction with membrane gangliosides
- (2010) Katsumi Matsuzaki et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- MEGF10 functions as a receptor for the uptake of amyloid-β
- (2010) Thoudam Debraj Singh et al. FEBS LETTERS
- Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains
- (2010) A. Kodam et al. GLIA
- Alzheimer's disease genetics: current knowledge and future challenges
- (2010) Paul Hollingworth et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease
- (2010) Sudha Seshadri JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer’s
- (2010) Ivan A. Borbon et al. JOURNAL OF APPLIED GENETICS
- Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
- (2010) C. Cecchi et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane
- (2010) Mariagioia Zampagni et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- The Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice
- (2010) Henri J. Huttunen et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Amyloid- Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability
- (2010) I. Allaman et al. JOURNAL OF NEUROSCIENCE
- Modulation of ABCA1 by an LXR Agonist Reduces Beta-Amyloid Levels and Improves Outcome after Traumatic Brain Injury
- (2010) David J. Loane et al. JOURNAL OF NEUROTRAUMA
- Endocytic pathways mediating oligomeric Abeta42 neurotoxicity
- (2010) Chunjiang Yu et al. Molecular Neurodegeneration
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- How Cholesterol Constrains Glycolipid Conformation for Optimal Recognition of Alzheimer's β Amyloid Peptide (Aβ1-40)
- (2010) Nouara Yahi et al. PLoS One
- ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD
- (2010) E. Y. Bryleva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipid Rafts As a Membrane-Organizing Principle
- (2010) D. Lingwood et al. SCIENCE
- Decreased Clearance of CNS -Amyloid in Alzheimer's Disease
- (2010) K. G. Mawuenyega et al. SCIENCE
- Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E
- (2009) Jianjia Fan et al. BIOFACTORS
- Cholesterol in Alzheimers Disease: Unresolved Questions
- (2009) Massimo Stefani et al. Current Alzheimer Research
- Apolipoprotein E receptors in the nervous system
- (2009) Joachim Herz CURRENT OPINION IN LIPIDOLOGY
- Cholesterol and statins in Alzheimer's disease: Current controversies
- (2009) Ana Catarina R.G. Fonseca et al. EXPERIMENTAL NEUROLOGY
- Cholesterol metabolism and transport in the pathogenesis of Alzheimerâs disease
- (2009) Ian J. Martins et al. JOURNAL OF NEUROCHEMISTRY
- Increased Membrane Cholesterol Might Render Mature Hippocampal Neurons More Susceptible to -Amyloid-Induced Calpain Activation and Tau Toxicity
- (2009) A. M. Nicholson et al. JOURNAL OF NEUROSCIENCE
- Microglia Mediate the Clearance of Soluble A through Fluid Phase Macropinocytosis
- (2009) S. Mandrekar et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial Cholesterol Loading Exacerbates Amyloid Peptide-Induced Inflammation and Neurotoxicity
- (2009) A. Fernandez et al. JOURNAL OF NEUROSCIENCE
- -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of -Carboxyl Terminal Fragment
- (2009) M. Takami et al. JOURNAL OF NEUROSCIENCE
- -Amyloid Monomers Are Neuroprotective
- (2009) M. L. Giuffrida et al. JOURNAL OF NEUROSCIENCE
- Risk Factors for Dementia
- (2009) Jen-Hau Chen et al. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
- Therapeutic potential of statins in Alzheimer's disease
- (2009) Nagaendran Kandiah et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation
- (2009) Ayelén Bulloj et al. Molecular Neurodegeneration
- Alzheimer's disease: synaptic dysfunction and Aβ
- (2009) Ganesh M Shankar et al. Molecular Neurodegeneration
- Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology
- (2009) Steve Pedrini et al. Molecular Neurodegeneration
- Presenilins are essential for regulating neurotransmitter release
- (2009) Chen Zhang et al. NATURE
- Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
- (2009) Jean-Charles Lambert et al. NATURE GENETICS
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
- (2009) Denise Harold et al. NATURE GENETICS
- Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
- (2009) Guojun Bu NATURE REVIEWS NEUROSCIENCE
- Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
- (2009) Jennifer L. Tomic et al. NEUROBIOLOGY OF DISEASE
- Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance
- (2009) Jungsu Kim et al. NEURON
- The Role of Apolipoprotein E in Alzheimer's Disease
- (2009) Jungsu Kim et al. NEURON
- Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan
- (2009) R. W. Halford et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease
- (2009) L. Serneels et al. SCIENCE
- Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors
- (2008) Marjan Shafaati et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Oligomer-specific Aβ toxicity in cell models is mediated by selective uptake
- (2008) Sidhartha M. Chafekar et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease
- (2008) James Scott Miners et al. BRAIN PATHOLOGY
- Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide
- (2008) Ming-Shen Lin et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Reduced Risk of Incident AD with Elective Statin Use in a Clinical Trial Cohort
- (2008) D. Sparks et al. Current Alzheimer Research
- The Cholesterol Transport Inhibitor U18666a Regulates Amyloid Precursor Protein Metabolism and Trafficking in N2aAPP “Swedish” Cells
- (2008) Warren Davis Jr. Current Alzheimer Research
- Intramembrane Proteolysis by γ-Secretase
- (2008) Harald Steiner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment
- (2008) Pamela Osenkowski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid β-Protein Assembly and Alzheimer Disease
- (2008) Robin Roychaudhuri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
- (2008) Rashid Deane et al. JOURNAL OF CLINICAL INVESTIGATION
- Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models
- (2008) Hong Qing et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Formation of Toxic Aβ(1–40) Fibrils on GM1 Ganglioside-Containing Membranes Mimicking Lipid Rafts: Polymorphisms in Aβ(1–40) Fibrils
- (2008) Takuma Okada et al. JOURNAL OF MOLECULAR BIOLOGY
- Novel N-terminal Cleavage of APP Precludes Aβ Generation in ACAT-Defective AC29 Cells
- (2008) Henri J. Huttunen et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
- (2008) Lakshmi Thirumangalakudi et al. JOURNAL OF NEUROCHEMISTRY
- Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study
- (2008) M D M Haag et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship
- (2008) Peter T. Nelson et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer’s disease
- (2008) R.P. Jaya Prasanthi et al. MECHANISMS OF AGEING AND DEVELOPMENT
- The Selective Alzheimer's Disease Indicator-1 Gene (Seladin-1/DHCR24) Is a Liver X Receptor Target Gene
- (2008) Y. Wang et al. MOLECULAR PHARMACOLOGY
- DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice
- (2008) C.R. Hooijmans et al. NEUROBIOLOGY OF DISEASE
- Cholesterol Potentiates β-Amyloid-Induced Toxicity in Human Neuroblastoma Cells: Involvement of Oxidative Stress
- (2008) Patricia Ferrera et al. NEUROCHEMICAL RESEARCH
- Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
- (2008) Z. Arvanitakis et al. NEUROLOGY
- ApoE Promotes the Proteolytic Degradation of Aβ
- (2008) Qingguang Jiang et al. NEURON
- The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain
- (2008) Lubica Cibickova et al. STEROIDS
- Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function
- (2007) S. Lesné et al. NEUROSCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search