Article
Geriatrics & Gerontology
Katharine K. Brewster, Mei-Chen Hu, Sigal Zilcha-Mano, Alexandra Stein, Patrick J. Brown, Melanie M. Wall, Steven P. Roose, Justin S. Golub, Bret R. Rutherford
Summary: The study found that older adults with treated hearing loss are at increased risk for depression and conversion to dementia. Baseline depression is a strong independent predictor of dementia development. Although the development or persistence of depression is associated with dementia, the mediation effect of depression on the relationship between hearing loss and dementia is minimal.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Patricia A. Boyle, Tianhao Wang, Lei Yu, Robert S. Wilson, Robert Dawe, Konstantinos Arfanakis, Julie A. Schneider, David A. Bennett
Summary: The study found that cognitive decline in old age is driven by a wide array of neuropathologies, with Alzheimer's disease, infarcts, non-Alzheimer's disease neurodegenerative diseases, and cerebrovascular conditions playing significant roles. While most pathological indices were associated with faster decline, they only accounted for a portion of the variation in decline, highlighting the complexity of cognitive ageing.
Article
Psychiatry
Ajay Sood, Robert S. Wilson, Lei Yu, Tianhao Wang, Julie A. Schneider, William G. Honer, David A. Bennett
Summary: The objective of this study was to evaluate the association between selective serotonin reuptake inhibitor (SSRI) use and late-life cognitive decline, as well as investigate the relationship with brain pathology. The study found that SSRI use was linked to a faster rate of global cognitive decline, regardless of pre-existing cognitive impairment. Furthermore, SSRI use was associated with higher levels of tau tangles and a more rapid cognitive decline in individuals who underwent neuropathologic examination. However, when considering both SSRI use and tangles in the same model, the association with cognitive decline was reduced and no longer statistically significant. This suggests that the use of SSRI may be related to higher tau tangles postmortem, potentially due to the treatment of neurobehavioral symptoms associated with dementia.
PSYCHIATRY RESEARCH
(2023)
Article
Geriatrics & Gerontology
Markus J. Haapanen, Tuija M. Mikkola, Lauri Kortelainen, Juulia Jylhava, Niko S. Wasenius, Eero Kajantie, Johan G. Eriksson, Mikaela B. von Bonsdorff
Summary: Body mass index (BMI) may not accurately predict frailty, as lean mass and fat mass may have different associations with frailty. Abdominal obesity (waist-to-hip ratio) in late midlife may be related to higher levels of frailty in men, while higher adiposity (percent body fat) in late midlife may be associated with higher levels of frailty in women.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Ophthalmology
Sanjeeb Bhandari, Susan Vitale, Elvira Agron, Traci E. Clemons, Emily Y. Chew
Summary: A prospective cohort study within the AREDS2 trial evaluated the risk of late AMD development after cataract surgery, and found that cataract surgery did not increase the risk of late AMD among participants with up to 10 years of follow-up.
Article
Rehabilitation
Elham Mahmoudi, Paul Lin, Mark D. Peterson, Michelle A. Meade, Denise G. Tate, Neil Kamdar
Summary: Middle-aged and older adults with traumatic spinal cord injury (TSCI) have a higher risk of developing Alzheimer disease and related dementia (ADRD). Improved clinical screening and early interventions to preserve cognitive function are crucial for this patient population.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Oncology
Chenran Wang, Yuting Chang, Jingyu Ren, Zheng Wu, Yadi Zheng, Zilin Luo, Chao Qin, Wei Cao, Fei Wang, Yongjie Xu, Liang Zhao, Xuesi Dong, Changfa Xia, Jiang Li, Jiansong Ren, Jufang Shi, Jibin Li, Kaiyong Zou, Wanqing Chen, Fengwei Tan, Ni Li, Jie He
Summary: This study investigated the relationship between lung cancer mortality and disability-adjusted life years in China and modifiable and nonmodifiable risk factors. The majority of lung cancer deaths and years of healthy life lost were attributable to behavioral and environmental risk clusters. Mitigating risk factors to the theoretical minimum level could lead to significant gains in life expectancy, particularly in terms of reducing tobacco use. The growth of the adult population was identified as the main driver of the changing burden of lung cancer with age.
Article
Geriatrics & Gerontology
Zijian Qin, Zheran Liu, Ruidan Li, Yaxin Luo, Zhigong Wei, Ling He, Yiyan Pei, Yonglin Su, Xiaolin Hu, Xingchen Peng
Summary: A declining BMI trend and high variation in late-middle age were associated with a higher risk of dementia. Early monitoring of these individuals is needed to prevent dementia in older individuals.
Article
Clinical Neurology
Sanish Sathyan, Emmeline Ayers, Dristi Adhikari, Tina Gao, Sofiya Milman, Nir Barzilai, Joe Verghese
Summary: Motoric cognitive risk (MCR) syndrome, characterized by slow gait and subjective cognitive concerns, is associated with biological age acceleration. Accelerated aging predicts risk for MCR and is associated with higher mortality in MCR patients.
ANNALS OF NEUROLOGY
(2023)
Article
Cell Biology
Zhi-Ren Tsai, Han-Wei Zhang, Chun-Hung Tseng, Hsiao-Ching Peng, Victor C. Kok, Gao Ping Li, Chao A. Hsiung, Chun-Yi Hsu
Summary: A retrospective cohort study conducted in Taiwan showed that individuals with epilepsy are at a significantly increased risk of developing dementia, especially those aged 50 years and above.
Article
Clinical Neurology
Seyed Ahmad Sajjadi, Syed Bukhari, Kiana A. Scambray, Rui Yan, Claudia Kawas, Thomas J. Montine, Maria M. Corrada
Summary: LATE-NC is a prevalent degenerative pathology in the oldest-old, with significant associations with dementia and cognitive impairment. Past medical histories of hypertension and osteoarthritis are associated with a lower likelihood of LATE-NC.
Article
Multidisciplinary Sciences
Inga Menze, Patrick Mueller, Notger G. Mueller, Marlen Schmicker
Summary: This study examined the impact of restrictive measures during the COVID-19 pandemic on cognitive performance. The results showed that depression and the impact of restrictions had a negative effect on objective cognitive performance, especially among younger participants. Loneliness and depression also affected the subjective evaluation of cognition.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Unhee Lim, Songren Wang, Song-Yi Park, David Bogumil, Anna H. Wu, Iona Cheng, Christopher A. Haiman, Loic Le Marchand, Lynne R. Wilkens, Lon White, V. Wendy Setiawan
Summary: Limited data is available for comparing sex- and race/ethnicity-specific risks of Alzheimer's disease and related dementia. The study found differences in risk of ADRD among different sexes and race/ethnicities, which were attenuated by adjusting for education and cardiometabolic diseases. More research is needed to further understand these differences.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Kristen M. George, Paola Gilsanz, Rachel L. Peterson, Lisa L. Barnes, Charles S. DeCarli, Elizabeth Rose Mayeda, Dan M. Mungas, Rachel A. Whitmer
Summary: The study revealed that cardiovascular risk factors (CVRFs) in adolescence, young adulthood, and midlife are associated with late-life cognitive decline, with hypertension and diabetes having negative impacts on executive function and verbal memory.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Kok Wai Giang, Anders Jeppsson, Martin Karlsson, Emma C. Hansson, Aldina Pivodic, Ingmar Skoog, Martin Lindgren, Susanne J. Nielsen
Summary: Overall, the long-term risk for all-cause dementia does not differ significantly between CABG patients and the general population. Younger patients have a higher risk compared to controls, while older patients have a lower risk.
ALZHEIMERS & DEMENTIA
(2021)