Establishing neuronal diversity in the spinal cord: a time and a place

A single-cell molecular map of mouse gastrulation and early organogenesis

(2019) Blanca Pijuan-Sala et al.   NATURE

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord

(2019) Julien Delile et al.   DEVELOPMENT

The HMG box transcription factors Sox1a and Sox1b specify a new class of glycinergic interneuron in the spinal cord of zebrafish embryos

(2019) Vanessa Gerber et al.   DEVELOPMENT

Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes

(2019) Begüm Aydin et al.   NATURE NEUROSCIENCE

Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification

(2019) Brian S. Clark et al.   NEURON

Positional Strategies for Connection Specificity and Synaptic Organization in Spinal Sensory-Motor Circuits

(2019) Nikolaos Balaskas et al.   NEURON

Molecular Logic of Spinocerebellar Tract Neuron Diversity and Connectivity

(2019) Myungin Baek et al.   Cell Reports

BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids

(2019) Nathalie Duval et al.   DEVELOPMENT

Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord

(2019) Audrey Harris et al.   Frontiers in Cellular Neuroscience

Single-Cell Transcriptomics Meets Lineage Tracing

(2018) Lennart Kester et al.   Cell Stem Cell

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control

(2018) Marito Hayashi et al.   NEURON

Origin and Segmental Diversity of Spinal Inhibitory Interneurons

(2018) Lora B. Sweeney et al.   NEURON

Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding

(2018) Alexander B. Rosenberg et al.   SCIENCE

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics

(2018) Andreas Sagner et al.   PLOS BIOLOGY

Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells

(2018) Sandeep Gupta et al.   Stem Cell Reports

A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility

(2018) Darren A. Cusanovich et al.   CELL

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Rnf220cooperates withZc4h2to specify spinal progenitor domains

(2018) Jumee Kim et al.   DEVELOPMENT

Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells

(2018) Takenori Ogura et al.   DEVELOPMENT

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq

(2018) Ana B. Muñoz-Manchado et al.   Cell Reports

Nervous System Regionalization Entails Axial Allocation before Neural Differentiation

(2018) Vicki Metzis et al.   CELL

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons

(2018) Phuong T. Hoang et al.   NEURON

Neuronal specification in space and time

(2018) Isabel Holguera et al.   SCIENCE

Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy

(2018) Jin Hui Hor et al.   Cell Death & Disease

Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development

(2017) Abbas H Rizvi et al.   NATURE BIOTECHNOLOGY

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division

(2017) Murielle Saade et al.   NATURE CELL BIOLOGY

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles

(2017) Alana I. Mendelsohn et al.   NEURON

Correction for Ranga et al., Neural tube morphogenesis in synthetic 3D microenvironments

(2017)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of V2a interneurons from human pluripotent stem cells

(2017) Jessica C. Butts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding of position in the developing neural tube from antiparallel morphogen gradients

(2017) Marcin Zagorski et al.   SCIENCE

Repression by PRDM13 is critical for generating precision in neuronal identity

(2017) Bishakha Mona et al.   eLife

Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells

(2017) Matthew J Sternfeld et al.   eLife

BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities

(2017) Madeline G Andrews et al.   eLife

Mouse embryonic stem cells can differentiate via multiple paths to the same state

(2017) James Alexander Briggs et al.   eLife

Morphogen interpretation: concentration, time, competence, and signaling dynamics

(2017) Andreas Sagner et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development

(2017) Karolina U. Kabayiza et al.   Frontiers in Molecular Neuroscience

Bayesian Sparse Regression Analysis Documents the Diversity of Spinal Inhibitory Interneurons

(2016) Mariano I. Gabitto et al.   CELL

Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits

(2016) Jay B. Bikoff et al.   CELL

Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics

(2016) Karthik Shekhar et al.   CELL

Making sense out of spinal cord somatosensory development

(2016) Helen C. Lai et al.   DEVELOPMENT

Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs

(2016) Eva Kutejova et al.   DEVELOPMENTAL CELL

Revealing the vectors of cellular identity with single-cell genomics

(2016) Allon Wagner et al.   NATURE BIOTECHNOLOGY

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers

(2016) Ho Sung Rhee et al.   NEURON

Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification

(2016) G. Christopher Tan et al.   Cell Reports

Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes

(2016) Yoanne M. Clovis et al.   Cell Reports

Morphogen rules: design principles of gradient-mediated embryo patterning

(2015) J. Briscoe et al.   DEVELOPMENT

A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors

(2015) Yuichi Nishi et al.   DEVELOPMENT

Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitment

(2015) Andrew M. Ravanelli et al.   GENES & DEVELOPMENT

Directed Differentiation of V3 Interneurons from Mouse Embryonic Stem Cells

(2015) Hao Xu et al.   STEM CELLS AND DEVELOPMENT

Developmental Pattern Formation in Phases

(2015) Anna Kicheva et al.   TRENDS IN CELL BIOLOGY

Molecular and cellular development of spinal cord locomotor circuitry

(2015) Daniel C. Lu et al.   Frontiers in Molecular Neuroscience

Deterministic HOX Patterning in Human Pluripotent Stem Cell-Derived Neuroectoderm

(2015) Ethan S. Lippmann et al.   Stem Cell Reports

A theoretical framework for the regulation of Shh morphogen-controlled gene expression

(2014) M. Cohen et al.   DEVELOPMENT

Neurogenin3 Restricts Serotonergic Neuron Differentiation to the Hindbrain

(2014) A. L. Carcagno et al.   JOURNAL OF NEUROSCIENCE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Tgfβ Signaling Regulates Temporal Neurogenesis and Potency of Neural Stem Cells in the CNS

(2014) José M. Dias et al.   NEURON

Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development

(2014) Darshan Sapkota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordination of progenitor specification and growth in mouse and chick spinal cord

(2014) A. Kicheva et al.   SCIENCE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity

(2014) Mina Gouti et al.   PLOS BIOLOGY

3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells

(2014) Andrea Meinhardt et al.   Stem Cell Reports

Morphogen interpretation: the transcriptional logic of neural tube patterning

(2013) Michael Cohen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Temporal control of BMP signalling determines neuronal subtype identity in the dorsal neural tube

(2013) S. Tozer et al.   DEVELOPMENT

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

(2013) Esteban O Mazzoni et al.   NATURE NEUROSCIENCE

Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

(2013) Esteban O Mazzoni et al.   NATURE NEUROSCIENCE

Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization

(2013) Polyxeni Philippidou et al.   NEURON

Identification of Multiple Subsets of Ventral Interneurons and Differential Distribution along the Rostrocaudal Axis of the Developing Spinal Cord

(2013) Cédric Francius et al.   PLoS One

SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals

(2013) T. Oosterveen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sonic Hedgehog Signaling Switches the Mode of Division in the Developing Nervous System

(2013) Murielle Saade et al.   Cell Reports

PLZF Regulates Fibroblast Growth Factor Responsiveness and Maintenance of Neural Progenitors

(2013) Zachary B. Gaber et al.   PLOS BIOLOGY

Genetic and Functional Modularity of Hox Activities in the Specification of Limb-Innervating Motor Neurons

(2013) Julie Lacombe et al.   PLoS Genetics

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

(2012) Nikolaos Balaskas et al.   CELL

Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification

(2012) A. Roy et al.   DEVELOPMENT

Dorsal-ventral patterning of the neural tube: A tale of three signals

(2012) Gwenvael Le Dréau et al.   Developmental Neurobiology

Polycomb repressive complex 1 activities determine the columnar organization of motor neurons

(2012) M. G. Golden et al.   GENES & DEVELOPMENT

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning

(2012) K. A. Peterson et al.   GENES & DEVELOPMENT

Renshaw Cells and Ia Inhibitory Interneurons Are Generated at Different Times from p1 Progenitors and Differentiate Shortly after Exiting the Cell Cycle

(2012) A. Benito-Gonzalez et al.   JOURNAL OF NEUROSCIENCE

Sustained Hox5 gene activity is required for respiratory motor neuron development

(2012) Polyxeni Philippidou et al.   NATURE NEUROSCIENCE

Sox9 and NFIA Coordinate a Transcriptional Regulatory Cascade during the Initiation of Gliogenesis

(2012) Peng Kang et al.   NEURON

Morphogen Gradients: From Generation to Interpretation

(2011) Katherine W. Rogers et al.   Annual Review of Cell and Developmental Biology

Patterns of Spinal Sensory-Motor Connectivity Prescribed by a Dorsoventral Positional Template

(2011) Gülşen Sürmeli et al.   CELL

Motor Neuron Position and Topographic Order Imposed by β- and γ-Catenin Activities

(2011) Elena Y. Demireva et al.   CELL

SnapShot: Spinal Cord Development

(2011) William A. Alaynick et al.   CELL

Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program

(2011) F. J. Stam et al.   DEVELOPMENT

Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling

(2011) K. Skaggs et al.   DEVELOPMENT

In Vivo Neuronal Subtype-Specific Targets of Atoh1 (Math1) in Dorsal Spinal Cord

(2011) H. C. Lai et al.   JOURNAL OF NEUROSCIENCE

Motor antagonism exposed by spatial segregation and timing of neurogenesis

(2011) Marco Tripodi et al.   NATURE

Temporally matched subpopulations of selectively interconnected principal neurons in the hippocampus

(2011) Yuichi Deguchi et al.   NATURE NEUROSCIENCE

Timing of neurogenesis is a determinant of olfactory circuitry

(2011) Fumiaki Imamura et al.   NATURE NEUROSCIENCE

From Cradle to Grave: The Multiple Roles of Fibroblast Growth Factors in Neural Development

(2011) François Guillemot et al.   NEURON

Mir-17-3p Controls Spinal Neural Progenitor Patterning by Regulating Olig2/Irx3 Cross-Repressive Loop

(2011) Jun-An Chen et al.   NEURON

Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis

(2011) Shaun Mahony et al.   GENOME BIOLOGY

Global Control of Motor Neuron Topography Mediated by the Repressive Actions of a Single Hox Gene

(2010) Heekyung Jung et al.   NEURON

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

(2010) Eric Dessaud et al.   PLOS BIOLOGY

LMO4 Controls the Balance between Excitatory and Inhibitory Spinal V2 Interneurons

(2009) Kaumudi Joshi et al.   NEURON

A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord

(2008) Dominique Bröhl et al.   DEVELOPMENTAL BIOLOGY

A Regulatory Network to Segregate the Identity of Neuronal Subtypes

(2008) Seunghee Lee et al.   DEVELOPMENTAL CELL

Regulation of Motor Neuron Specification by Phosphorylation of Neurogenin 2

(2008) Yong-Chao Ma et al.   NEURON