Membrane cholesterol access into a G-protein-coupled receptor

Interaction of G protein coupled receptors and cholesterol

(2016) Gerald Gimpl   CHEMISTRY AND PHYSICS OF LIPIDS

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors

(2016) Ramon Guixà-González et al.   Scientific Reports

7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome

(2016) Myriam Gou-Fàbregas et al.   Scientific Reports

Allosteric regulation of G protein–coupled receptor activity by phospholipids

(2015) Rosie Dawaliby et al.   Nature Chemical Biology

Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation

(2014) Cristina Sensi et al.   CELLULAR SIGNALLING

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

Opsin, a Structural Model for Olfactory Receptors?

(2013) Jung Hee Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Altered fatty acid concentrations in prefrontal cortex of schizophrenic patients

(2013) Ameer Y. Taha et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Cholesterol as a co-solvent and a ligand for membrane proteins

(2013) Yuanli Song et al.   PROTEIN SCIENCE

Bendix: intuitive helix geometry analysis and abstraction

(2012) A. C. E. Dahl et al.   BIOINFORMATICS

Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters

(2012) Mariona Jové et al.   CARDIOVASCULAR RESEARCH

Potential Therapeutic Relevance of Adenosine A2B and A2A Receptors in the Central Nervous System

(2012) Patrizia Popoli et al.   CNS & Neurological Disorders-Drug Targets

Molecular Characterization of Oxysterol Binding to the Epstein-Barr Virus-induced Gene 2 (GPR183)

(2012) Tau Benned-Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predictions for Cholesterol Interaction Sites on the A2A Adenosine Receptor

(2012) Ji Young Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxysterols are allosteric activators of the oncoprotein Smoothened

(2012) Sigrid Nachtergaele et al.   Nature Chemical Biology

Effect of channel mutations on the uptake and release of the retinal ligand in opsin

(2012) R. Piechnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol increases kinetic, energetic, and mechanical stability of the human  2-adrenergic receptor

(2012) M. Zocher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

The Morphology and Composition of Cholesterol-Rich Micellar Nanostructures Determine Transmembrane Protein (GPCR) Activity

(2011) Michelle A. O'Malley et al.   BIOPHYSICAL JOURNAL

Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

(2011) Joanne Oates et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Update of the Cholesterol Force Field Parameters in CHARMM

(2011) Joseph B. Lim et al.   JOURNAL OF PHYSICAL CHEMISTRY B

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor

(2010) Dow P. Hurst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive blood plasma lipidomics by liquid chromatography/quadrupole time-of-flight mass spectrometry

(2010) Koen Sandra et al.   JOURNAL OF CHROMATOGRAPHY A

Cholesterol Modulates the Membrane Effects and Spatial Organization of Membrane-Penetrating Ligands for G-Protein Coupled Receptors

(2010) George Khelashvili et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes

(2009) Sunhwan Jo et al.   BIOPHYSICAL JOURNAL

Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways

(2009) Pavel Michal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CHAMBER: Comprehensive support for CHARMM force fields within the AMBER software

(2009) Michael F. Crowley et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Ligand Entry and Exit Pathways in the β2-Adrenergic Receptor

(2009) Ting Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

A Ligand Channel through the G Protein Coupled Receptor Opsin

(2009) Peter W. Hildebrand et al.   PLoS One

A Role for a Specific Cholesterol Interaction in Stabilizing the Apo Configuration of the Human A 2A Adenosine Receptor

(2009) Edward Lyman et al.   STRUCTURE

Potential Therapeutic Interest of Adenosine A2A Receptors in Psychiatric Disorders

(2008) Rodrigo Cunha et al.   CURRENT PHARMACEUTICAL DESIGN

The function of G-protein coupled receptors and membrane cholesterol: specific or general interaction?

(2008) Yamuna Devi Paila et al.   GLYCOCONJUGATE JOURNAL

Perspective on Diabatic Models of Chemical Reactivity as Illustrated by the Gas-Phase SN2 Reaction of Acetate Ion with 1,2-Dichloroethane

(2008) Rosendo Valero et al.   Journal of Chemical Theory and Computation

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Embedded cholesterol in the nicotinic acetylcholine receptor

(2008) G. Brannigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder

(2008) Robert K. McNamara et al.   PSYCHIATRY RESEARCH

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE