Obesity and cancer, a case for insulin signaling

The association between glucose-lowering drug use and mortality among breast cancer patients with type 2 diabetes

(2015) Pauline A. J. Vissers et al.   BREAST CANCER RESEARCH AND TREATMENT

Non-small cell lung cancer cell survival crucially depends on functional insulin receptors

(2015) Carolin Maria Frisch et al.   ENDOCRINE-RELATED CANCER

Highly specific role of the insulin receptor in breast cancer progression

(2015) R. Rostoker et al.   ENDOCRINE-RELATED CANCER

Partial and Generalized Lipodystrophy: Comparison of Baseline Characteristics and Response to Metreleptin

(2015) Talia Diker-Cohen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of Metformin vs Placebo on and Metabolic Factors in NCIC CTG MA.32

(2015) P. J. Goodwin et al.   JNCI-Journal of the National Cancer Institute

Global burden of cancer attributable to high body-mass index in 2012: a population-based study

(2015) Melina Arnold et al.   LANCET ONCOLOGY

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

(2015) Matthias Blüher et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

(2015) C. Tomasetti et al.   SCIENCE

Effect of Metformin vs Placebo on and Metabolic Factors in NCIC CTG MA.32

(2015) P. J. Goodwin et al.   JNCI-Journal of the National Cancer Institute

Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling

(2014) Altaf Mohammed et al.   Translational Oncology

Insulin Receptor Phosphorylation by Endogenous Insulin or the Insulin Analog AspB10 Promotes Mammary Tumor Growth Independent of the IGF-I Receptor

(2013) E. J. Gallagher et al.   DIABETES

Overexpression of the Insulin Receptor Isoform A Promotes Endometrial Carcinoma Cell Growth

(2013) Chun-Fang Wang et al.   PLoS One

Reduction of Insulin Resistance and Plasma Glucose Level by Salsalate Treatment in Persons with Prediabetes

(2012) Elham Faghihimani et al.   Endocrine Practice

Proinsulin Binds with High Affinity the Insulin Receptor Isoform A and Predominantly Activates the Mitogenic Pathway

(2012) Roberta Malaguarnera et al.   ENDOCRINOLOGY

Mitogenic and anti-apoptotic effects of insulin in endometrial cancer are phosphatidylinositol 3-kinase/Akt dependent

(2012) Yingmei Wang et al.   GYNECOLOGIC ONCOLOGY

Metformin and Incident Breast Cancer among Diabetic Women: A Population-Based Case-Control Study in Denmark

(2011) J. L. F. Bosco et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

(2011) Motoharu Awazawa et al.   Cell Metabolism

Does intentional weight loss reduce cancer risk?

(2011) T. Byers et al.   DIABETES OBESITY & METABOLISM

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells

(2010) Mahvash Zakikhani et al.   BREAST CANCER RESEARCH AND TREATMENT

Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

(2010) Pamela J. Goodwin et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis

(2010) R. M. Memmott et al.   Cancer Prevention Research

Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes

(2010) R. Novosyadlyy et al.   CANCER RESEARCH

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling

(2010) L. Sciacca et al.   DIABETOLOGIA

Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation

(2010) H Zhang et al.   ONCOGENE

Obesity and leptin resistance: distinguishing cause from effect

(2010) Martin G. Myers et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

(2009) Ling He et al.   CELL

 -Cell Hyperplasia Induced by Hepatic Insulin Resistance: Role of a Liver-Pancreas Endocrine Axis Through Insulin Receptor A Isoform

(2009) O. Escribano et al.   DIABETES

Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial

(2009) Lars Sjöström et al.   LANCET ONCOLOGY

Molecular targets for treatment of inflammatory breast cancer

(2009) Hideko Yamauchi et al.   Nature Reviews Clinical Oncology

Forecasting the Effects of Obesity and Smoking on U.S. Life Expectancy

(2009) Susan T. Stewart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Estrogen action: A historic perspective on the implications of considering alternative approaches

(2009) Elwood V. Jensen et al.   PHYSIOLOGY & BEHAVIOR

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

(2008) Vuk Stambolic et al.   BREAST CANCER RESEARCH AND TREATMENT

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

(2008) J. H. Law et al.   CANCER RESEARCH

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Insulin-Lowering Effects of Metformin in Women with Early Breast Cancer

(2008) Pamela J. Goodwin et al.   Clinical Breast Cancer

Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

(2008) Allison B. Goldfine et al.   CTS-Clinical and Translational Science

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

(2008) C. Regazzetti et al.   DIABETES

Deconvolution of Insulin Secretion, Insulin Hepatic Extraction Post-hepatic Delivery Rates and Sensitivity during 24-hour Standardized Meals: Time Course of Glucose Homeostasis in Leptin Replacement Treatment

(2008) V. Andreev et al.   HORMONE AND METABOLIC RESEARCH

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Clinical Significance in Healthy Men of the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration

(2008) In Ho Chang et al.   JOURNAL OF UROLOGY

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

Insulin receptor expression by human prostate cancers

(2008) Michael E. Cox et al.   PROSTATE