Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage

(2021) Yang Cao et al.   Neuroscience Bulletin

Inhibition of Ferroptosis Alleviates Early Brain Injury After Subarachnoid Hemorrhage In Vitro and In Vivo via Reduction of Lipid Peroxidation

(2020) Yuchen Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis and Its Potential Role in Human Diseases

(2020) Chu Han et al.   Frontiers in Pharmacology

The Potential Value of Targeting Ferroptosis in Early Brain Injury After Acute CNS Disease

(2020) Junhui Chen et al.   Frontiers in Molecular Neuroscience

Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats

(2020) Bin Lan et al.   Journal of Integrative Medicine-JIM

Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke

(2020) Jie Liu et al.   Frontiers in Cellular Neuroscience

On the role of synthesized hydroxylated chalcones as dual functional amyloid-β aggregation and ferroptosis inhibitors for potential treatment of Alzheimer's disease

(2019) Lin Cong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage

(2019) Thomas Gaberel et al.   STROKE

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial

(2019) Magdy Selim et al.   LANCET NEUROLOGY

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

(2019) Yanhua Mou et al.   Journal of Hematology & Oncology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects

(2019) Bin Chen et al.   BRAIN RESEARCH BULLETIN

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation

(2019) Xueying Guan et al.   LIFE SCIENCES

Neurovascular Unit as a Source of Ischemic Stroke Biomarkers—Limitations of Experimental Studies and Perspectives for Clinical Application

(2019) Aleksandra Steliga et al.   Translational Stroke Research

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

(2019) Yansheng Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models

(2018) H. Karatas et al.   BRAIN RESEARCH

The role of Ca 2+ in cell death caused by oxidative glutamate toxicity and ferroptosis

(2018) Pamela Maher et al.   CELL CALCIUM

P2X7 Receptor-Associated Programmed Cell Death in the Pathophysiology of Hemorrhagic Stroke

(2018) Hengli Zhao et al.   Current Neuropharmacology

The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact

(2018) Elizabeth Ignowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Ultrastructural Characteristics of Neuronal Death and White Matter Injury in Mouse Brain Tissues After Intracerebral Hemorrhage: Coexistence of Ferroptosis, Autophagy, and Necrosis

(2018) Qian Li et al.   Frontiers in Neurology

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

(2018) Nuria DeGregorio-Rocasolano et al.   Redox Biology

Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

(2018) Zhuwei Zhang et al.   BRAIN RESEARCH

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

(2018) Andrew Hinman et al.   PLoS One

Iron status and dietary iron intake in vegetarians

(2018) Aleksandra Śliwińska et al.   Advances in Clinical and Experimental Medicine

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

(2018) Saravanan S. Karuppagounder et al.   ANNALS OF NEUROLOGY

Non-transferrin-bound iron transporters

(2018) Mitchell D. Knutson   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

(2018) Nikhlesh K. Singh et al.   PROGRESS IN LIPID RESEARCH

Iron Status and Risk of Stroke

(2018) Dipender Gill et al.   STROKE

Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury

(2018) Hongwei Liu et al.   Translational Stroke Research

Imatinib and spironolactone suppress hepcidin expression

(2017) Katarzyna Mleczko-Sanecka et al.   HAEMATOLOGICA

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

(2017) Xiaoyan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Stroke in women — from evidence to inequalities

(2017) Charlotte Cordonnier et al.   Nature Reviews Neurology

Effects of dietary RRR α-tocopherol vs all-racemic α-tocopherol on health outcomes

(2017) Katherine M Ranard et al.   NUTRITION REVIEWS

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

(2017) Shumei Ma et al.   PLoS One

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Ferroptosis Inhibition: Mechanisms and Opportunities

(2017) Jose Pedro Friedmann Angeli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Imatinib and spironolactone suppress hepcidin expression

(2017) Katarzyna Mleczko-Sanecka et al.   HAEMATOLOGICA

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Toll-Like Receptor 4/MyD88–Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral HemorrhageClinical Perspective

(2016) Xiao-Yi Xiong et al.   CIRCULATION

Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine

(2016) Robert H. LeBlanc et al.   Journal of Neuroinflammation

HIF-1α triggers long-lasting glutamate excitotoxicity via system xc − in cerebral ischaemia-reperfusion

(2016) Chia-Hung Hsieh et al.   JOURNAL OF PATHOLOGY

Role of hepcidin and its downstream proteins in early brain injury after experimental subarachnoid hemorrhage in rats

(2016) Guanping Tan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Brain iron overload following intracranial haemorrhage

(2016) Thomas Garton et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

An overview of molecular basis of iron metabolism regulation and the associated pathologies

(2015) Bruno Silva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease

(2015) Joanne J. Liu et al.   BRAIN RESEARCH

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons

(2015) Changyi Ji et al.   JOURNAL OF NEUROCHEMISTRY

Main path and byways: non-vesicular glutamate release by system xc−as an important modifier of glutamatergic neurotransmission

(2015) Ann Massie et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of  -Amyloid Precursor Protein

(2015) S. Ayton et al.   JOURNAL OF NEUROSCIENCE

Hepcidin Levels Are Increased in Patients with Acute Ischemic Stroke: Preliminary Report

(2015) Artur Słomka et al.   Journal of Stroke & Cerebrovascular Diseases

Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells

(2015) Junghyung Park et al.   TOXICOLOGY

Hepcidin Levels Are Increased in Patients with Acute Ischemic Stroke: Preliminary Report

(2015) Artur Słomka et al.   Journal of Stroke & Cerebrovascular Diseases

Docosahexaenoic (DHA) modulates phospholipid-hydroperoxide glutathione peroxidase (Gpx4) gene expression to ensure self-protection from oxidative damage in hippocampal cells

(2015) Verónica Casañas-Sánchez et al.   Frontiers in Physiology

Mechanistic and regulatory aspects of intestinal iron absorption

(2014) Sukru Gulec et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A chemical screen identifies small molecules that regulate hepcidin expression

(2014) Vera Gaun et al.   BLOOD CELLS MOLECULES AND DISEASES

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The potential of 12/15-lipoxygenase inhibitors in stroke therapy

(2014) Klaus van Leyen et al.   Future Medicinal Chemistry

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

(2014) Thomas Sonnweber et al.   GUT

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

miRNA expression is modulated over time after focal ischaemia: up-regulation of miR-347 promotes neuronal apoptosis

(2013) Carme Gubern et al.   FEBS Journal

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke

(2012) Kazim Yigitkanli et al.   ANNALS OF NEUROLOGY

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Rosiglitazone treatment reduces hippocampal neuronal damage possibly through alleviating oxidative stress in chronic cerebral hypoperfusion

(2012) Hale Sayan-Ozacmak et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Increased expression of cystine/glutamate antiporter in multiple sclerosis

(2011) Olatz Pampliega et al.   Journal of Neuroinflammation

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain

(2011) Hui Ding et al.   PLoS One

Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington’s disease mice

(2010) Junghee Lee et al.   ACTA NEUROPATHOLOGICA

Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke

(2010) Ludmila Belayev et al.   Translational Stroke Research

The Relationship between Hematoma Iron Content and Perihematoma Edema: An MRI Study

(2009) Min Lou et al.   CEREBROVASCULAR DISEASES

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

(2008) Elizabeth L. Mackenzie et al.   ANTIOXIDANTS & REDOX SIGNALING

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Protecting Against Cerebrovascular Injury

(2008) Guang Jin et al.   STROKE