Main path and byways: non-vesicular glutamate release by system xc−as an important modifier of glutamatergic neurotransmission

Crucial role of astrocytes in temporal lobe epilepsy

(2016) C. Steinhäuser et al.   NEUROSCIENCE

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc−, the Na+-independent glutamate–cystine exchanger

(2015) Jing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-Dependent upregulation of glutathione synthesis

(2015) Yan He et al.   GLIA

Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

(2015) Sho Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

(2015) Kou Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of SystemXc−Transporter Attenuates Autoimmune Inflammatory Demyelination

(2015) Kirsten S. Evonuk et al.   JOURNAL OF IMMUNOLOGY

Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells

(2015) Katja Linher-Melville et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex

(2015) D B McClatchy et al.   MOLECULAR PSYCHIATRY

MPTP-induced parkinsonism in mice alters striatal and nigral xCT expression but is unaffected by the genetic loss of xCT

(2015) Eduard Bentea et al.   NEUROSCIENCE LETTERS

Lack of effect of Theiler’s murine encephalomyelitis virus infection on system xc−

(2015) Ellen Merckx et al.   NEUROSCIENCE LETTERS

Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision

(2015) Eduard Bentea et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Reactive oxygen species-mediated therapeutic response and resistance in glioblastoma

(2015) E Singer et al.   Cell Death & Disease

Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport

(2015) William C. Griffin et al.   Frontiers in Pharmacology

Behavioral characterization of system xc- mutant mice

(2014) Elizabeth A. McCullagh et al.   BEHAVIOURAL BRAIN RESEARCH

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−

(2014) Yuzhe Yang et al.   CANCER RESEARCH

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

(2014) Yonju Ha et al.   CELL AND TISSUE RESEARCH

Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damage

(2014) Federico N. Soria et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Hippocampal Synaptic Strength by Glial xCT

(2014) L. E. Williams et al.   JOURNAL OF NEUROSCIENCE

Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes

(2014) T. Tsujita et al.   MOLECULAR AND CELLULAR BIOLOGY

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

(2014) Bindu D. Paul et al.   NATURE

Dysregulation of system xc− expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

(2014) Natalie M. Frederick et al.   NEUROCHEMISTRY INTERNATIONAL

Sulfasalazine and temozolomide with radiation therapy for newly diagnosed glioblastoma

(2014) Satoru Takeuchi et al.   NEUROLOGY INDIA

Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11

(2014) L Martin et al.   ONCOGENE

Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate levels in P rats

(2014) Hasan Alhaddad et al.   PSYCHOPHARMACOLOGY

Behavioral assessment of acute inhibition of system xc - in rats

(2014) Victoria Lutgen et al.   PSYCHOPHARMACOLOGY

Augmented cystine-glutamate exchange by pituitary adenylate cyclase-activating polypeptide signaling via the VPAC1 receptor

(2014) Jon M. Resch et al.   SYNAPSE

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of the Group I mGluRs Reduces Acute Brain Damage and Improves Long-Term Histological Outcomes after Photothrombosis-Induced Ischaemia

(2013) Hailong Li et al.   ASN Neuro

FGF-2 induces neuronal death through upregulation of system xc-

(2013) XiaoQian Liu et al.   BRAIN RESEARCH

Regulation of system xc− in the SOD1-G93A mouse model of ALS

(2013) Rebecca Albano et al.   EXPERIMENTAL NEUROLOGY

Using EAE to better understand principles of immune function and autoimmune pathology

(2013) Manu Rangachari et al.   JOURNAL OF AUTOIMMUNITY

Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling

(2013) Philip O. Scumpia et al.   NEUROCHEMISTRY INTERNATIONAL

Novel di-aryl-substituted isoxazoles act as noncompetitive inhibitors of the system xc- cystine/glutamate exchanger

(2013) J.L. Newell et al.   NEUROCHEMISTRY INTERNATIONAL

Dysregulation of Dopamine and Glutamate Release in the Prefrontal Cortex and Nucleus Accumbens Following Methamphetamine Self-Administration and During Reinstatement in Rats

(2013) Aram Parsegian et al.   NEUROPSYCHOPHARMACOLOGY

Increased Extracellular Glutamate In the Nucleus Accumbens Promotes Excessive Ethanol Drinking in Ethanol Dependent Mice

(2013) William C Griffin III et al.   NEUROPSYCHOPHARMACOLOGY

JAKs and STATs in Immunity, Immunodeficiency, and Cancer

(2013) John J. O'Shea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of mGluR5 neurotransmission in reinstated cocaine-seeking

(2012) Xiusong Wang et al.   ADDICTION BIOLOGY

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Non-Cell Autonomous Influence of the Astrocyte System xc− on Hypoglycaemic Neuronal Cell Death

(2012) Nicole A Jackman et al.   ASN Neuro

Impaired long-term potentiation and long-term memory deficits in xCT-deficientsutmice

(2012) Yan Li et al.   BIOSCIENCE REPORTS

Regulators of synaptic transmission: Roles in the pathogenesis and treatment of epilepsy

(2012) Pablo M. Casillas-Espinosa et al.   EPILEPSIA

Sulfasalazine for brain cancer fits

(2012) Harald Sontheimer et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells

(2012) Márcio Ribeiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ceftriaxone Normalizes Nucleus Accumbens Synaptic Transmission, Glutamate Transport, and Export following Cocaine Self-Administration and Extinction Training

(2012) H. Trantham-Davidson et al.   JOURNAL OF NEUROSCIENCE

Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas

(2012) Satoru Takeuchi et al.   NEUROSURGERY

N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: Behavioral and biochemical analyses in rats

(2012) Irena Smaga et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Ceftriaxone prevents the induction of cocaine sensitization and produces enduring attenuation of cue- and cocaine-primed reinstatement of cocaine-seeking

(2011) Ilan Sondheimer et al.   BEHAVIOURAL BRAIN RESEARCH

Antioxidants in Huntington's disease

(2011) Ashu Johri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression

(2011) J Lewerenz et al.   CELL DEATH AND DIFFERENTIATION

System xc− regulates microglia and macrophage glutamate excitotoxicity in vivo

(2011) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

Increased expression of cystine/glutamate antiporter in multiple sclerosis

(2011) Olatz Pampliega et al.   Journal of Neuroinflammation

Loss of System xFormula Does Not Induce Oxidative Stress But Decreases Extracellular Glutamate in Hippocampus and Influences Spatial Working Memory and Limbic Seizure Susceptibility

(2011) D. De Bundel et al.   JOURNAL OF NEUROSCIENCE

SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments

(2011) Peter I. Joyce et al.   MAMMALIAN GENOME

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Functional upregulation of system xc− by fibroblast growth factor-2

(2011) XiaoQian Liu et al.   NEUROPHARMACOLOGY

Distinct Neurochemical Adaptations Within the Nucleus Accumbens Produced by a History of Self-Administered vs Non-Contingently Administered Intravenous Methamphetamine

(2011) Kevin D Lominac et al.   NEUROPSYCHOPHARMACOLOGY

Dopaminergic neurons of system xc−-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity

(2010) Ann Massie et al.   FASEB JOURNAL

Regulation of System xc−Activity and Expression in Astrocytes by Interleukin-1β

(2010) Nicole A. Jackman et al.   GLIA

Extinction Training after Cocaine Self-Administration Induces Glutamatergic Plasticity to Inhibit Cocaine Seeking

(2010) L. A. Knackstedt et al.   JOURNAL OF NEUROSCIENCE

N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a Novel Metabotropic Glutamate 2 Potentiator with Potential Anxiolytic/Antidepressant Properties: In Vivo Profiling Suggests a Link between Behavioral and Central Nervous System Neurochemical Changes

(2010) M. J. Fell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse

(2010) K. Moussawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bermuda Triangle of cocaine-induced neuroadaptations

(2010) Marina E. Wolf   TRENDS IN NEUROSCIENCES

Ceftriaxone Restores Glutamate Homeostasis and Prevents Relapse to Cocaine Seeking

(2009) Lori A. Knackstedt et al.   BIOLOGICAL PSYCHIATRY

Isoxazole analogues bind the System xc- transporter: Structure–activity relationship and pharmacophore model

(2009) Sarjubhai A. Patel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

β-N-methylamino-l-alanine induces oxidative stress and glutamate release through action on system Xc−

(2009) XiaoQian Liu et al.   EXPERIMENTAL NEUROLOGY

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

Molecular regulation of antioxidant ability in the hippocampus of EL mice

(2008) Mayuko Takaki et al.   BRAIN RESEARCH

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity

(2008) R.E. Gonsette   JOURNAL OF THE NEUROLOGICAL SCIENCES

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

(2008) Kelly L. Conrad et al.   NATURE

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

(2008) Nicolai E Savaskan et al.   NATURE MEDICINE

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroprotection for ischemic stroke: Past, present and future

(2008) Myron D. Ginsberg   NEUROPHARMACOLOGY

Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats

(2008) Ann Massie et al.   NEUROREPORT

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

(2008) B.R. Miller et al.   NEUROSCIENCE

Current Status of Neuroprotection for Cerebral Ischemia: Synoptic Overview

(2008) M. D. Ginsberg   STROKE

Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis

(2007) F. Matrisciano et al.   NEUROPHARMACOLOGY

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function

(2003) Steven W. Barger et al.   JOURNAL OF NEUROCHEMISTRY