Brain iron overload following intracranial haemorrhage

Hemoglobin-induced neuronal degeneration in the hippocampus after neonatal intraventricular hemorrhage

(2016) Thomas P. Garton et al.   BRAIN RESEARCH

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bilirubin-Induced Neurotoxicity in the Preterm Neonate

(2016) Jon F. Watchko   CLINICS IN PERINATOLOGY

Iron homeostasis

(2016) Shanshan Guo et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin

(2016) Jing Chen-Roetling et al.   JOURNAL OF NEUROCHEMISTRY

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

(2016) Bo Ma et al.   Journal of Neuroinflammation

The Choroid Plexus in Healthy and Diseased Brain

(2016) Charanjit Kaur et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Role of hepcidin and its downstream proteins in early brain injury after experimental subarachnoid hemorrhage in rats

(2016) Guanping Tan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity

(2016) Ziyan Zhang et al.   NEUROCHEMICAL RESEARCH

Knockout of ho-1 protects the striatum from ferrous iron-induced injury in a male-specific manner in mice

(2016) Li-Fang Wang et al.   Scientific Reports

Intraventricular Hemorrhage: the Role of Blood Components in Secondary Injury and Hydrocephalus

(2016) Thomas Garton et al.   Translational Stroke Research

Metal Ion Toxins and Brain Aquaporin-4 Expression: An Overview

(2016) Adriana Ximenes-da-Silva   Frontiers in Neuroscience

A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage

(2016) Guang Yang et al.   Scientific Reports

Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage

(2015) Huiying Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The importance of eukaryotic ferritins in iron handling and cytoprotection

(2015) P. Arosio et al.   BIOCHEMICAL JOURNAL

Deferoxamine alleviates chronic hydrocephalus after intraventricular hemorrhage through iron chelation and Wnt1/Wnt3a inhibition

(2015) Hui Meng et al.   BRAIN RESEARCH

CHMP4B, ESCRT-III associating protein, associated with neuronal apoptosis following intracerebral hemorrhage

(2015) Jiabing Shen et al.   BRAIN RESEARCH

The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer’s Disease

(2015) Meng Qian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Iron regulatory proteins and their role in controlling iron metabolism

(2015) Lukas C. Kühn   Metallomics

Effect Comparison of Both Iron Chelators on Outcomes, Iron Deposit, and Iron Transporters After Intracerebral Hemorrhage in Rats

(2015) Gaiqing Wang et al.   MOLECULAR NEUROBIOLOGY

Up-regulation of VCAM1 Relates to Neuronal Apoptosis After Intracerebral Hemorrhage in Adult Rats

(2015) Dongmei Zhang et al.   NEUROCHEMICAL RESEARCH

The iron-regulatory hormone hepcidin: A possible therapeutic target?

(2015) Luc Rochette et al.   PHARMACOLOGY & THERAPEUTICS

Intracerebral Hematoma Contributes to Hydrocephalus After Intraventricular Hemorrhage via Aggravating Iron Accumulation

(2015) Qianwei Chen et al.   STROKE

Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells

(2015) Junghyung Park et al.   TOXICOLOGY

Biliverdin reductase isozymes in metabolism

(2015) Luke O’Brien et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Iron Deposition Is Positively Related to Cognitive Impairment in Patients with Chronic Mild Traumatic Brain Injury: Assessment with Susceptibility Weighted Imaging

(2015) Liyan Lu et al.   Biomed Research International

Efficacy of Deferoxamine in Animal Models of Intracerebral Hemorrhage: A Systematic Review and Stratified Meta-Analysis

(2015) Han-Jin Cui et al.   PLoS One

The Clinical Effect of Deferoxamine Mesylate on Edema after Intracerebral Hemorrhage

(2015) Yao Yu et al.   PLoS One

Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy

(2015) Li-Fang Wang et al.   PLoS One

Endothelin-1-mediated vasoconstriction alters cerebral gene expression in iron homeostasis and eicosanoid metabolism

(2014) Justin S. Bickford et al.   BRAIN RESEARCH

Brain CD47 expression in a swine model of intracerebral hemorrhage

(2014) Xiang Zhou et al.   BRAIN RESEARCH

Upregulated Expression of SSTR1 is Involved in Neuronal Apoptosis and is Coupled to the Reduction of bcl-2 Following Intracerebral Hemorrhage in Adult Rats

(2014) Damin Yuan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Up-Regulation of c-Fos Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage

(2014) Xiaomei Chen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Iron Overload is Associated with Perihematoma Edema Growth Following Intracerebral Hemorrhage that may Contribute to In-hospital Mortality and Long-term Functional Outcome

(2014) Babak Bakhshayesh et al.   CURRENT NEUROVASCULAR RESEARCH

Altered Expression of Aquaporin 1 and 5 in the Choroid Plexus following Preterm Intraventricular Hemorrhage

(2014) Snjolaug Sveinsdottir et al.   DEVELOPMENTAL NEUROSCIENCE

Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron

(2014) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

ADAM17 at the interface between inflammation and autoimmunity

(2014) Sabrina Lisi et al.   IMMUNOLOGY LETTERS

Role of Red Blood Cell Lysis and Iron in Hydrocephalus after Intraventricular Hemorrhage

(2014) Chao Gao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Extracellular hemoglobin - mediator of inflammation and cell death in the choroid plexus following preterm intraventricular hemorrhage

(2014) Magnus Gram et al.   Journal of Neuroinflammation

The Neuroprotection of Lysosomotropic Agents in Experimental Subarachnoid Hemorrhage Probably Involving the Apoptosis Pathway Triggering by Cathepsins via Chelating Intralysosomal Iron

(2014) Yang Wang et al.   MOLECULAR NEUROBIOLOGY

Brain Iron Metabolism and Brain Injury Following Subarachnoid Hemorrhage: iCeFISH-Pilot (CSF Iron in SAH)

(2014) Joao A. Gomes et al.   Neurocritical Care

The ferric iron chelator 2,2′-dipyridyl attenuates basilar artery vasospasm and improves neurological function after subarachnoid hemorrhage in rabbits

(2014) Yaoyu Yu et al.   NEUROLOGICAL SCIENCES

Role of Hemoglobin and Iron in Hydrocephalus After Neonatal Intraventricular Hemorrhage

(2014) Jennifer M. Strahle et al.   NEUROSURGERY

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Deferoxamine Attenuates Acute Hydrocephalus After Traumatic Brain Injury in Rats

(2014) Jinbing Zhao et al.   Translational Stroke Research

Impact of Heme and Heme Degradation Products on Vascular Diameter in Mouse Visual Cortex

(2014) Alexander Joerk et al.   Journal of the American Heart Association

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

Systemic iron chelation results in limited functional and histological recovery after traumatic spinal cord injury in rats

(2013) Andrew Sauerbeck et al.   EXPERIMENTAL NEUROLOGY

A Calcineurin Docking Motif (LXVP) in Dynamin-related Protein 1 Contributes to Mitochondrial Fragmentation and Ischemic Neuronal Injury

(2013) Andrew M. Slupe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats

(2013) Huiqing Sun et al.   JOURNAL OF MOLECULAR HISTOLOGY

Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states

(2013) Peter Hahl et al.   JOURNAL OF NEUROCHEMISTRY

The Presence and Role of Iron in Mild Traumatic Brain Injury: An Imaging Perspective

(2013) Eric J. Nisenbaum et al.   JOURNAL OF NEUROTRAUMA

Mitochondrial calcium uniporter blocker effectively prevents brain mitochondrial dysfunction caused by iron overload

(2013) Jirapas Sripetchwandee et al.   LIFE SCIENCES

Enhanced Brain Delivery of Deferasirox–Lactoferrin Conjugates for Iron Chelation Therapy in Neurodegenerative Disorders: In Vitro and in Vivo Studies

(2013) Golnaz Kamalinia et al.   MOLECULAR PHARMACEUTICS

High Dose Deferoxamine in Intracerebral Hemorrhage (Hi-Def) Trial: Rationale, Design, and Methods

(2013) Sharon D. Yeatts et al.   Neurocritical Care

New Developments in the Treatment of Intracerebral Hemorrhage

(2013) Joao A. Gomes et al.   NEUROLOGIC CLINICS

The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging

(2013) Jens Haugbølle Thomsen et al.   Oxidative Medicine and Cellular Longevity

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

Intravenous Minocycline in Acute Stroke

(2013) Edith Kohler et al.   STROKE

Deferoxamine Attenuates White Matter Injury in a Piglet Intracerebral Hemorrhage Model

(2013) Qing Xie et al.   STROKE

Bipyridine, an Iron Chelator, Does Not Lessen Intracerebral Iron-Induced Damage or Improve Outcome After Intracerebral Hemorrhagic Stroke in Rats

(2013) Jayalakshmi Caliaperumal et al.   Translational Stroke Research

Deferoxamine Reduces Neuronal Death and Hematoma Lysis After Intracerebral Hemorrhage in Aged Rats

(2013) Tetsuhiro Hatakeyama et al.   Translational Stroke Research

Iron and Intracerebral Hemorrhage: From Mechanism to Translation

(2013) Xiao-Yi Xiong et al.   Translational Stroke Research

Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous System

(2013) Bongki Cho et al.   Experimental Neurobiology

CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects

(2012) Anders Etzerodt et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

International Epidemiology of Intracerebral Hemorrhage

(2012) M. Arfan Ikram et al.   Current Atherosclerosis Reports

Crystallographic studies of heme oxygenase complexed with an unstable reaction intermediate, verdoheme

(2012) Masaki Unno et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury

(2012) Lijun Zhang et al.   NEUROLOGICAL SCIENCES

Increased expression of ferritin in cerebral cortex after human traumatic brain injury

(2012) Huan-Dong Liu et al.   NEUROLOGICAL SCIENCES

Minocycline Prevents IL-6 Increase after Acute Ischemic Stroke

(2012) Jeffrey A. Switzer et al.   Translational Stroke Research

Brain Iron Quantification in Mild Traumatic Brain Injury: A Magnetic Field Correlation Study

(2011) E. Raz et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Hepcidin Treatment Modulates the Expression of Divalent Metal Transporter-1, Ceruloplasmin, and Ferroportin-1 in the Rat Cerebral Cortex and Hippocampus

(2011) Lin Li et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Iron Regulation of Hepcidin Despite Attenuated Smad1,5,8 Signaling in Mice Without Transferrin Receptor 2 or Hfe

(2011) Elena Corradini et al.   GASTROENTEROLOGY

A pilot trial of deferiprone for neurodegeneration with brain iron accumulation

(2011) G. Abbruzzese et al.   HAEMATOLOGICA

Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein

(2011) Katherine C. M. Chew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy of the lipid-soluble iron chelator 2,2′-dipyridyl against hemorrhagic brain injury

(2011) He Wu et al.   NEUROBIOLOGY OF DISEASE

Effects of statin and deferoxamine administration on neurological outcomes in a rat model of intracerebral hemorrhage

(2011) Hyoung-Joon Chun et al.   NEUROLOGICAL SCIENCES

Soluble CD163

(2011) Holger J. Møller   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Minocycline-Induced Attenuation of Iron Overload and Brain Injury After Experimental Intracerebral Hemorrhage

(2011) Fan Zhao et al.   STROKE

Matrix Metalloproteinase-9 in an Exploratory Trial of Intravenous Minocycline for Acute Ischemic Stroke

(2011) Jeffrey A. Switzer et al.   STROKE

Safety and Tolerability of Deferoxamine Mesylate in Patients With Acute Intracerebral Hemorrhage

(2011) Magdy Selim et al.   STROKE

Iron Enhances the Neurotoxicity of Amyloid β

(2011) Lin Wang et al.   Translational Stroke Research

Serum ferritin: Past, present and future

(2010) Wei Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Haptoglobin: Old protein with new functions

(2010) Abdu I. Alayash   CLINICA CHIMICA ACTA

Effects of Aquaporin-4 on edema formation following intracerebral hemorrhage

(2010) Yuping Tang et al.   EXPERIMENTAL NEUROLOGY

Endothelin-1 gene regulation

(2010) Lisa R. Stow et al.   FASEB JOURNAL

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

(2010) Hyun-Hee Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemoglobin and Iron Handling in Brain after Subarachnoid Hemorrhage and the Effect of Deferoxamine on Early Brain Injury

(2010) Jin-Yul Lee et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Iron Toxicity in Mice with Collagenase-Induced Intracerebral Hemorrhage

(2010) He Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice

(2010) Lifen Chen et al.   JOURNAL OF NEUROSURGERY

Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis

(2010) Charlotte JJ van Asch et al.   LANCET NEUROLOGY

Minocycline to Improve Neurologic Outcome in Stroke (MINOS)

(2010) Susan C. Fagan et al.   STROKE

Iron-Related Brain Damage in Patients With Intracerebral Hemorrhage

(2010) Natalia Pérez de la Ossa et al.   STROKE

Role of Iron in Brain Injury After Intraventricular Hemorrhage

(2010) Zhi Chen et al.   STROKE

Evolutionary Aspects of Hemoglobin Scavengers

(2009) Krzysztof B. Wicher et al.   ANTIOXIDANTS & REDOX SIGNALING

Hemoglobin and Heme Scavenger Receptors

(2009) Marianne Jensby Nielsen et al.   ANTIOXIDANTS & REDOX SIGNALING

Minocycline attenuates iron neurotoxicity in cortical cell cultures

(2009) Jing Chen-Roetling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neurons express hemoglobin α- and β-chains in rat and human brains

(2009) Franziska Richter et al.   JOURNAL OF COMPARATIVE NEUROLOGY

HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues

(2009) Hillel Zukor et al.   JOURNAL OF NEUROCHEMISTRY

Elevated metals compromise repair of oxidative DNA damage via the base excision repair pathway: implications of pathologic iron overload in the brain on integrity of neuronal DNA

(2009) Hui Li et al.   JOURNAL OF NEUROCHEMISTRY

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroprotective Role of Haptoglobin after Intracerebral Hemorrhage

(2009) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Oxidative Stress in Brain According to Traumatic Brain Injury Intensity

(2009) Fabricia Petronilho et al.   JOURNAL OF SURGICAL RESEARCH

Cerebral microbleeds: a guide to detection and interpretation

(2009) Steven M Greenberg et al.   LANCET NEUROLOGY

Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review

(2009) Valery L Feigin et al.   LANCET NEUROLOGY

Post-acute pathological changes in the thalamus and internal capsule in aged mice following controlled cortical impact injury: A magnetic resonance imaging, iron histochemical, and glial immunohistochemical study

(2009) Gregory Onyszchuk et al.   NEUROSCIENCE LETTERS

Intraventricular Hemorrhage in Premature Infants: Mechanism of Disease

(2009) Praveen Ballabh   PEDIATRIC RESEARCH

Unexpected expression of  - and  -globin in mesencephalic dopaminergic neurons and glial cells

(2009) M. Biagioli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pathology of superficial siderosis of the central nervous system

(2008) Arnulf H. Koeppen et al.   ACTA NEUROPATHOLOGICA

CD163, a Marker of Perivascular Macrophages, Is Up-Regulated by Microglia in Simian Immunodeficiency Virus Encephalitis after Haptoglobin-Hemoglobin Complex Stimulation and Is Suggestive of Breakdown of the Blood-Brain Barrier

(2008) Juan T. Borda et al.   AMERICAN JOURNAL OF PATHOLOGY

Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells

(2008) Richard G. Ruddell et al.   HEPATOLOGY

Iron Homeostasis: Recently Identified Proteins Provide Insight into Novel Control Mechanisms

(2008) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Hemoglobin in Rodent Neurons

(2008) Dominik W Schelshorn et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain edema after intracerebral hemorrhage in rats: the role of iron overload and aquaporin 4

(2008) Wang Gai Qing et al.   JOURNAL OF NEUROSURGERY

Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin

(2008) Raymond F. Regan et al.   NEUROBIOLOGY OF DISEASE

Temporal changes in free iron levels after brain ischemia

(2008) Emilie Millerot-Serrurot et al.   NEUROCHEMISTRY INTERNATIONAL

Minocycline reduces intracerebral hemorrhage-induced brain injury

(2008) Jimin Wu et al.   NEUROLOGICAL RESEARCH

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MRI Detection of Secondary Damage After Stroke

(2008) Carles Justicia et al.   STROKE

Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke

(2008) Yoshihiro Murata et al.   STROKE

Deferoxamine Mesylate: A New Hope for Intracerebral Hemorrhage: From Bench to Clinical Trials

(2008) M. Selim   STROKE

Association Between Serum Ferritin Level and Perihematoma Edema Volume in Patients With Spontaneous Intracerebral Hemorrhage

(2008) Manu Mehdiratta et al.   STROKE