Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction
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Title
Synergistic effects of brain injury and aging: common mechanisms of proteostatic dysfunction
Authors
Keywords
unfolded protein response, heat shock response, ubiquitin-proteasome system, experimental models, cellular stress response, therapeutics
Journal
TRENDS IN NEUROSCIENCES
Volume 44, Issue 9, Pages 728-740
Publisher
Elsevier BV
Online
2021-07-20
DOI
10.1016/j.tins.2021.06.003
References
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Note: Only part of the references are listed.- Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
- (2020) Erika Kelmer Sacramento et al. Molecular Systems Biology
- Dynamic neural and glial responses of a head-specific model for traumatic brain injury inDrosophila
- (2020) Janani Saikumar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mild hypothermia reduces endoplasmic reticulum stress-induced apoptosis and improves neuronal functions after severe traumatic brain injury
- (2019) Chuan-Fang Wang et al. Brain and Behavior
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- (2019) Evert Njomen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Salubrinal offers neuroprotection through suppressing endoplasmic reticulum stress, autophagy and apoptosis in a mouse traumatic brain injury model
- (2019) Zu-feng Wang et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia
- (2019) Neil SN Graham et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury
- (2019) Tao Chen et al. NEUROSCIENCE
- Aberrant ER-stress induced neuronal-IFNβ elicits white matter injury due to microglial activation and T-cell infiltration after TBI
- (2019) Tanusree Sen et al. JOURNAL OF NEUROSCIENCE
- Inducing Mild Traumatic Brain Injury in C. elegans via Cavitation-Free Surface Acoustic Wave-Driven Ultrasonic Irradiation
- (2019) Morteza Miansari et al. Scientific Reports
- Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma
- (2019) Karen Krukowski et al. JOURNAL OF NEUROTRAUMA
- Structure and Function of the 26S Proteasome
- (2018) Jared A.M. Bard et al. Annual Review of Biochemistry
- Spatial patterns of progressive brain volume loss after moderate-severe traumatic brain injury
- (2018) James H Cole et al. BRAIN
- Juvenile Traumatic Brain Injury Results in Cognitive Deficits Associated with Impaired Endoplasmic Reticulum Stress and Early Tauopathy
- (2018) Michael J. Hylin et al. DEVELOPMENTAL NEUROSCIENCE
- Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models
- (2018) Eric N Anderson et al. HUMAN MOLECULAR GENETICS
- Endoplasmic Reticulum Stress Contributes to the Loss of Newborn Hippocampal Neurons after Traumatic Brain Injury
- (2018) Kimberly N. Hood et al. JOURNAL OF NEUROSCIENCE
- Exercise Rehabilitation Attenuates Cognitive Deficits in Rats with Traumatic Brain Injury by Stimulating the Cerebral HSP20/BDNF/TrkB Signalling Axis
- (2018) Willy Chou et al. MOLECULAR NEUROBIOLOGY
- Molecular mechanisms driving transcriptional stress responses
- (2018) Anniina Vihervaara et al. NATURE REVIEWS GENETICS
- Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury
- (2018) Jun-Chao Liang et al. Neural Regeneration Research
- Mild TBI and risk of Parkinson disease
- (2018) Raquel C. Gardner et al. NEUROLOGY
- Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer’s disease.
- (2018) Jeff Schaffert et al. NEUROPSYCHOLOGY
- Curcumin mitigates axonal injury and neuronal cell apoptosis through the PERK/Nrf2 signaling pathway following diffuse axonal injury
- (2018) Tingqin Huang et al. NEUROREPORT
- IL-33/ST2L Signaling Provides Neuroprotection Through Inhibiting Autophagy, Endoplasmic Reticulum Stress, and Apoptosis in a Mouse Model of Traumatic Brain Injury
- (2018) Yuan Gao et al. Frontiers in Cellular Neuroscience
- Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study
- (2018) Anna Nordström et al. PLOS MEDICINE
- Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans
- (2018) Deborah E. Barnes et al. JAMA Neurology
- The Shrinking Brain: Cerebral Atrophy Following Traumatic Brain Injury
- (2018) Taylor C. Harris et al. ANNALS OF BIOMEDICAL ENGINEERING
- Accelerated age-related cortical thinning in mild traumatic brain injury
- (2018) Priya Santhanam et al. Brain and Behavior
- Exercise attenuates neurological deficits by stimulating a critical HSP70/NF-κB/IL-6/synapsin I axis in traumatic brain injury rats
- (2017) Chung-Ching Chio et al. Journal of Neuroinflammation
- Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury
- (2017) Tanusree Sen et al. JOURNAL OF NEUROSCIENCE
- Endoplasmic Reticulum Stress Modulation as a Target for Ameliorating Effects of Blast Induced Traumatic Brain Injury
- (2017) Brandon P. Lucke-Wold et al. JOURNAL OF NEUROTRAUMA
- Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury
- (2017) Yan Yin et al. MOLECULAR NEUROBIOLOGY
- Nrf2-ARE signaling provides neuroprotection in traumatic brain injury via modulation of the ubiquitin proteasome system
- (2017) Hui Ding et al. NEUROCHEMISTRY INTERNATIONAL
- Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury
- (2017) Austin Chou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Administration of Tauroursodeoxycholic Acid Attenuates Early Brain Injury via Akt Pathway Activation
- (2017) Dongdong Sun et al. Frontiers in Cellular Neuroscience
- Identification of HSP90 inhibitors as a novel class of senolytics
- (2017) Heike Fuhrmann-Stroissnigg et al. Nature Communications
- Integrated Stress Response as a Therapeutic Target for CNS Injuries
- (2017) Lorenzo Romero-Ramírez et al. Biomed Research International
- Salubrinal reduces oxidative stress, neuroinflammation and impulsive-like behavior in a rodent model of traumatic brain injury
- (2016) Aric F. Logsdon et al. BRAIN RESEARCH
- The integrated stress response
- (2016) Karolina Pakos‐Zebrucka et al. EMBO REPORTS
- Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy
- (2016) Brandon P. Lucke-Wold et al. JOURNAL OF NEUROSURGERY
- The mTOR signalling cascade: paving new roads to cure neurological disease
- (2016) Peter B. Crino Nature Reviews Neurology
- Calcineurin β protects brain after injury by activating the unfolded protein response
- (2016) Yanan Chen et al. NEUROBIOLOGY OF DISEASE
- Hsp70 inducer, 17-allylamino-demethoxygeldanamycin, provides neuroprotection via anti-inflammatory effects in a rat model of traumatic brain injury
- (2016) Youquan Gu et al. Experimental and Therapeutic Medicine
- Using Drosophila as an integrated model to study mild repetitive traumatic brain injury
- (2016) Ayeh Barekat et al. Scientific Reports
- Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction
- (2016) Nuno Miguel Luis et al. Cell Reports
- Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings
- (2016) Paul K. Crane et al. JAMA Neurology
- Traumatic brain injuries
- (2016) Kaj Blennow et al. Nature Reviews Disease Primers
- The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
- (2015) Ann C. McKee et al. ACTA NEUROPATHOLOGICA
- Prediction of brain age suggests accelerated atrophy after traumatic brain injury
- (2015) James H. Cole et al. ANNALS OF NEUROLOGY
- Administration of DHA Reduces Endoplasmic Reticulum Stress-Associated Inflammation and Alters Microglial or Macrophage Activation in Traumatic Brain Injury
- (2015) Lloyd D. Harvey et al. ASN Neuro
- The pharmacology of resveratrol in animals and humans
- (2015) Eun-Jung Park et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Inhibition of Eukaryotic Initiation Factor 2 Alpha Phosphatase Reduces Tissue Damage and Improves Learning and Memory after Experimental Traumatic Brain Injury
- (2015) Pramod K. Dash et al. JOURNAL OF NEUROTRAUMA
- The Neuroprotective Effect of Salubrinal in a Mouse Model of Traumatic Brain Injury
- (2015) Vardit Rubovitch et al. NEUROMOLECULAR MEDICINE
- Pharmacological induction of the 70-kDa heat shock protein protects against brain injury
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- Neuroprotection after Traumatic Brain Injury in Heat-Acclimated Mice Involves Induced Neurogenesis and Activation of Angiotensin Receptor Type 2 Signaling
- (2014) Gali Umschweif et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Therapeutic inducers of the HSP70/HSP110 protect mice against traumatic brain injury
- (2014) Binnur Eroglu et al. JOURNAL OF NEUROCHEMISTRY
- Docosahexaenoic Acid Reduces ER Stress and Abnormal Protein Accumulation and Improves Neuronal Function Following Traumatic Brain Injury
- (2014) G. Begum et al. JOURNAL OF NEUROSCIENCE
- Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms
- (2014) Aric Flint Logsdon et al. Frontiers in Cellular Neuroscience
- Chronic traumatic encephalopathy: a spectrum of neuropathological changes following repetitive brain trauma in athletes and military personnel
- (2014) Thor D Stein et al. Alzheimers Research & Therapy
- A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1
- (2014) Daniel W. Neef et al. Cell Reports
- Immunohistochemical Analysis of the Ubiquitin Proteasome System and Autophagy Lysosome System Induced After Traumatic Intracranial Injury
- (2013) Kentaro Sakai et al. AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY
- XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
- (2013) Rebecca C. Taylor et al. CELL
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Neuroprotective Effects of Geranylgeranylacetone in Experimental Traumatic Brain Injury
- (2013) Zaorui Zhao et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Hypoxia-Inducible Factor 1 is Essential for Spontaneous Recovery from Traumatic Brain Injury and is a Key Mediator of Heat Acclimation Induced Neuroprotection
- (2013) Gali Umschweif et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Reduced Insulin/Insulin-like Growth Factor-1 Signaling and Dietary Restriction Inhibit Translation but Preserve Muscle Mass inCaenorhabditis elegans
- (2013) Geert Depuydt et al. MOLECULAR & CELLULAR PROTEOMICS
- Chronic neuropathologies of single and repetitive TBI: substrates of dementia?
- (2013) Douglas H. Smith et al. Nature Reviews Neurology
- The 70 kDa heat shock protein protects against experimental traumatic brain injury
- (2013) Jong Youl Kim et al. NEUROBIOLOGY OF DISEASE
- A Drosophila model of closed head traumatic brain injury
- (2013) R. J. Katzenberger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aging- and injury-related differential apoptotic response in the dentate gyrus of the hippocampus in rats following brain trauma
- (2013) Dong Sun et al. Frontiers in Aging Neuroscience
- ER Stress and Effects of DHA as an ER Stress Inhibitor
- (2013) Gulnaz Begum et al. Translational Stroke Research
- The Ubiquitin Code
- (2012) David Komander et al. Annual Review of Biochemistry
- HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity
- (2012) Wei-Chung Chiang et al. CELL
- Protein damage, repair and proteolysis
- (2012) Niki Chondrogianni et al. MOLECULAR ASPECTS OF MEDICINE
- The unfolded protein response: controlling cell fate decisions under ER stress and beyond
- (2012) Claudio Hetz NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
- (2012) Alok Kumar et al. NEUROBIOLOGY OF AGING
- The nuclear factor erythroid 2-like 2 activator, tert-butylhydroquinone, improves cognitive performance in mice after mild traumatic brain injury
- (2012) J.N. Saykally et al. NEUROSCIENCE
- Influence of Age on Brain Edema Formation, Secondary Brain Damage and Inflammatory Response after Brain Trauma in Mice
- (2012) Ralph Timaru-Kast et al. PLoS One
- Molecular chaperones in protein folding and proteostasis
- (2011) F. Ulrich Hartl et al. NATURE
- Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
- (2011) Daniel W. Neef et al. NATURE REVIEWS DRUG DISCOVERY
- Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases-Progress and Prognosis
- (2011) S. L. Lindquist et al. Cold Spring Harbor Perspectives in Biology
- The Treatment of Traumatic Brain Injury with Velcade
- (2010) Changsheng Qu et al. JOURNAL OF NEUROTRAUMA
- Molecular mechanisms of proteasome plasticity in aging
- (2010) Karl A. Rodriguez et al. MECHANISMS OF AGEING AND DEVELOPMENT
- A photoconvertible reporter of the ubiquitin-proteasome system in vivo
- (2010) Geert Hamer et al. NATURE METHODS
- Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity
- (2010) S. Henis-Korenblit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans
- (2010) Della C. David et al. PLOS BIOLOGY
- Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
- (2009) MarÃa Paz Gavilán et al. AGING CELL
- Heat Acclimation Provides Sustained Improvement in Functional Recovery and Attenuates Apoptosis after Traumatic Brain Injury
- (2009) Gali Umschwief et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
- (2009) Ann C. McKee et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Disruption of the Ubiquitin Proteasome System following Axonal Stretch Injury Accelerates Progression to Secondary Axotomy
- (2009) Jerome A. Staal et al. JOURNAL OF NEUROTRAUMA
- A conserved ubiquitination pathway determines longevity in response to diet restriction
- (2009) Andrea C. Carrano et al. NATURE
- The proteasome: Overview of structure and functions
- (2009) Keiji TANAKA PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
- (2009) S. D. Westerheide et al. SCIENCE
- Microglial involvement in neuroprotection following experimental traumatic brain injury in heat-acclimated mice
- (2008) Na'ama A. Shein et al. BRAIN RESEARCH
- Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling
- (2008) N. Naidoo et al. JOURNAL OF NEUROSCIENCE
- Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process
- (2008) A. Tonoki et al. MOLECULAR AND CELLULAR BIOLOGY
- Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates
- (2008) A SIDAROS et al. NEUROIMAGE
- Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers
- (2007) Jonathan E. Nuss et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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