Integrated Stress Response as a Therapeutic Target for CNS Injuries

Salubrinal reduces oxidative stress, neuroinflammation and impulsive-like behavior in a rodent model of traumatic brain injury

(2016) Aric F. Logsdon et al.   BRAIN RESEARCH

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Neuroprotection and Blood-Brain Barrier Restoration by Salubrinal After a Cortical Stab Injury

(2016) M. Asunción Barreda-Manso et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Post-ischemic salubrinal treatment results in a neuroprotective role in global cerebral ischemia

(2016) Berta Anuncibay-Soto et al.   JOURNAL OF NEUROCHEMISTRY

Harnessing the integrated stress response for the treatment of multiple sclerosis

(2016) Sharon W Way et al.   LANCET NEUROLOGY

Neuroprotection by salubrinal treatment in global cerebral ischemia

(2016) Arsenio Fernández-López et al.   Neural Regeneration Research

eIF2α-Independent Inhibition of TNF-α-Triggered NF-κB Activation by Salubrinal

(2015) Shotaro Nakajima et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Salubrinal inhibits the expression of proteoglycans and favors neurite outgrowth from cortical neurons in vitro

(2015) M. Asunción Barreda-Manso et al.   EXPERIMENTAL CELL RESEARCH

Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke

(2015) Noriko Makihara et al.   EXPERIMENTAL NEUROLOGY

Functional differences between microglia and monocytes after ischemic stroke

(2015) Rodney M. Ritzel et al.   Journal of Neuroinflammation

Inhibition of Eukaryotic Initiation Factor 2 Alpha Phosphatase Reduces Tissue Damage and Improves Learning and Memory after Experimental Traumatic Brain Injury

(2015) Pramod K. Dash et al.   JOURNAL OF NEUROTRAUMA

All roads go to Salubrinal: endoplasmic reticulum stress, neuroprotection and glial scar formation

(2015) Lorenzo Romero-Ramírez et al.   Neural Regeneration Research

The Neuroprotective Effect of Salubrinal in a Mouse Model of Traumatic Brain Injury

(2015) Vardit Rubovitch et al.   NEUROMOLECULAR MEDICINE

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell–cell communication by chemokines

(2015) Stefka Gyoneva et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

(2015) Sharon W. Way et al.   Nature Communications

Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats

(2014) Xiao-Hong Cai et al.   EXPERIMENTAL NEUROLOGY

Glial scar and immune cell involvement in tissue remodeling and repair following acute CNS injuries

(2014) Catarina Raposo et al.   GLIA

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of GADD34, the Stress-Inducible Regulatory Subunit of the Endoplasmic Reticulum Stress Response, Does Not Enhance Functional Recovery after Spinal Cord Injury

(2014) Sujata Saraswat Ohri et al.   PLoS One

The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning

(2013) Bo Gao et al.   ACTA PHARMACOLOGICA SINICA

Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury

(2013) C. Soderblom et al.   JOURNAL OF NEUROSCIENCE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

Restoring endoplasmic reticulum homeostasis improves functional recovery after spinal cord injury

(2013) Sujata Saraswat Ohri et al.   NEUROBIOLOGY OF DISEASE

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice

(2012) Ellinor Kenne et al.   Journal of Neuroinflammation

Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway

(2011) Xiumei Huang et al.   NEUROBIOLOGY OF AGING

The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair

(2011) Ravid Shechter et al.   PLoS One

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Blood–Brain Barrier Pathophysiology in Traumatic Brain Injury

(2011) Adam Chodobski et al.   Translational Stroke Research

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The expression of matrix metalloproteinase-13 is increased in vessels with blood–brain barrier impairment in a stroke-prone hypertensive model

(2009) Masaki Ueno et al.   HYPERTENSION RESEARCH

Engulfment of Axon Debris by Microglia Requires p38 MAPK Activity

(2009) Tatsuhide Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved

(2009) Lianshun Zheng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats

(2009) Venkata Prasuja Nakka et al.   NEUROTOXICITY RESEARCH

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death

(2008) M Boyce et al.   CELL DEATH AND DIFFERENTIATION

Eif-2a Protects Brainstem Motoneurons in a Murine Model of Sleep Apnea

(2008) Y. Zhu et al.   JOURNAL OF NEUROSCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY