Circadian regulation of cancer cell and tumor microenvironment crosstalk

Circadian clock genes promote glioma progression by affecting tumour immune infiltration and tumour cell proliferation

(2021) Zeyu Wang et al.   CELL PROLIFERATION

Temporal regulation of tumor growth in nocturnal mammals: In vivo studies and chemotherapeutical potential

(2021) Paula M. Wagner et al.   FASEB JOURNAL

Clocks, cancer, and chronochemotherapy

(2021) Aziz Sancar et al.   SCIENCE

Cancer Stemness Meets Immunity: From Mechanism to Therapy

(2021) Peiwen Chen et al.   Cell Reports

Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans

(2021) Bala S.C. Koritala et al.   JOURNAL OF PINEAL RESEARCH

Circadian rhythm as a therapeutic target

(2021) Wei Ruan et al.   NATURE REVIEWS DRUG DISCOVERY

Context-Dependent Glioblastoma–Macrophage/Microglia Symbiosis and Associated Mechanisms

(2021) Wenjing Xuan et al.   TRENDS IN IMMUNOLOGY

Innate myeloid cells in the tumor microenvironment

(2021) Vikas Duhan et al.   CURRENT OPINION IN IMMUNOLOGY

Therapeutic Targeting of the Tumor Microenvironment

(2021) Leire Bejarano et al.   Cancer Discovery

Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment

(2020) Peiwen Chen et al.   Cancer Discovery

The aberrant expression of rhythm genes affects the genome instability and regulates the cancer immunity in pan‐cancer

(2020) Jian Zhou et al.   Cancer Medicine

Circadian variation in nivolumab efficacy in patients with advanced non-small cell lung cancer.

(2020) Abdoulaye Karaboué et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulatory T cells confer a circadian signature on inflammatory arthritis

(2020) L. E. Hand et al.   Nature Communications

Bmal1 integrates mitochondrial metabolism and macrophage activation

(2020) Ryan K Alexander et al.   eLife

Targeting Myeloid-Derived Suppressor Cell, a Promising Strategy to Overcome Resistance to Immune Checkpoint Inhibitors

(2020) Aohan Hou et al.   Frontiers in Immunology

Circadian clock is associated with tumor microenvironment in kidney renal clear cell carcinoma

(2020) Liangcheng Zhou et al.   Aging-US

Downregulation of the circadian rhythm regulator HLF promotes multiple-organ distant metastases in non-small cell lung cancer through PPAR/NF-κb signaling

(2020) Jiarong Chen et al.   CANCER LETTERS

Cancer-associated fibroblasts: key determinants of tumor immunity and immunotherapy

(2020) Richard Barrett et al.   CURRENT OPINION IN IMMUNOLOGY

Hypoxia, metabolism, and the circadian clock: new links to overcome radiation resistance in high-grade gliomas

(2020) Han Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

(2020) Eva Hadadi et al.   Nature Communications

RORα Regulates Cholesterol Metabolism of CD8+ T Cells for Anticancer Immunity

(2020) In Kyu Lee et al.   Cancers

Association Between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis

(2020) Aishe Dun et al.   Frontiers in Oncology

The role of microenvironment in tumor angiogenesis

(2020) Xianjie Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Circadian Clock and Complement Immune System—Complementary Control of Physiology and Pathology?

(2020) Pooja Shivshankar et al.   Frontiers in Cellular and Infection Microbiology

Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation

(2020) I. Aiello et al.   Science Advances

Stromal Expression of the Core Clock Gene Period 2 Is Essential for Tumor Initiation and Metastatic Colonization

(2020) Lee Shaashua et al.   Frontiers in Cell and Developmental Biology

Immunometabolic Interplay in the Tumor Microenvironment

(2020) Irem Kaymak et al.   CANCER CELL

Enhancing anti-tumour efficacy with immunotherapy combinations

(2020) Funda Meric-Bernstam et al.   LANCET

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

(2019) Ilana Chefetz et al.   Cell Reports

Association between circadian rhythms and neurodegenerative diseases

(2019) Yue Leng et al.   LANCET NEUROLOGY

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

(2019) José M. Adrover et al.   IMMUNITY

KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer

(2019) Wenting Liao et al.   CANCER CELL

The Intersection between Tumor Angiogenesis and Immune Suppression

(2019) Osama E. Rahma et al.   CLINICAL CANCER RESEARCH

Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma

(2019) Man Liu et al.   GUT

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

(2019) Alex Miranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma

(2019) Peiwen Chen et al.   CANCER CELL

Cancer and the Circadian Clock

(2019) Ayesha A. Shafi et al.   CANCER RESEARCH

Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation

(2019) Shabnam Shalapour et al.   IMMUNITY

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A

(2019) Elke Burgermeister et al.   EBioMedicine

The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes

(2019) Fuhr et al.   Cancers

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

(2019) Zhen Dong et al.   Cancer Discovery

New Insights Into the Circadian Rhythm and Its Related Diseases

(2019) Yanling Xie et al.   Frontiers in Physiology

Molecular mechanisms and physiological importance of circadian rhythms

(2019) Alina Patke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion

(2019) Yingcheng Wu et al.   Frontiers in Immunology

Circadian clock associates with tumor microenvironment in thoracic cancers

(2019) Yong Yang et al.   Aging-US

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

(2019) Sangeeta Goswami et al.   NATURE MEDICINE

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas

(2019) Joseph A. Flores-Toro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In VitroPriming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and StemnessIn Vivo

(2018) Xiao Hu et al.   CANCER RESEARCH

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

(2018) Max D. Wellenstein et al.   IMMUNITY

Circadian nutritional behaviours and cancer risk: New insights from the NutriNet-santé prospective cohort study: Disclaimers

(2018) Bernard Srour et al.   INTERNATIONAL JOURNAL OF CANCER

The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models

(2018) Panshak P. Dakup et al.   Oncotarget

Periostin Limits Tumor Response to VEGFA Inhibition

(2018) Ioanna Keklikoglou et al.   Cell Reports

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion

(2018) Xiaojuan Liu et al.   Cell Reports

Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

(2018) Wenyan He et al.   IMMUNITY

Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene

(2018) Chiharu Katamune et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of circadian gene 'hClock' contribution to metastasis of colorectal cancer

(2017) Yaping Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effective combinatorial immunotherapy for castration-resistant prostate cancer

(2017) Xin Lu et al.   NATURE

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

High-throughput genomic profiling of tumor-infiltrating leukocytes

(2016) Aaron M Newman et al.   CURRENT OPINION IN IMMUNOLOGY

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity

(2016) Caroline Baer et al.   NATURE CELL BIOLOGY

Circadian clocks: Not your grandfather’s clock

(2016) Fred W. Turek   SCIENCE

The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer

(2016) Ngoc-Han Ha et al.   PLoS Genetics

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity

(2016) Xiao Hu et al.   OncoImmunology

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

(2015) Zhiwei Hu et al.   CARCINOGENESIS

Overexpression of circadian clock protein cryptochrome (CRY) 1 alleviates sleep deprivation-induced vascular inflammation in a mouse model

(2015) Bing Qin et al.   IMMUNOLOGY LETTERS

Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

(2015) Niu Zhanfeng et al.   Oncotarget

Intratumoral Myeloid Cells Regulate Responsiveness and Resistance to Antiangiogenic Therapy

(2015) Lee B. Rivera et al.   Cell Reports

The circadian rhythm controls telomeres and telomerase activity

(2014) Wei-Dar Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Circadian Clock Proteins and Immunity

(2014) Anne M. Curtis et al.   IMMUNITY

Proteomics and circadian rhythms: It's all about signaling!

(2014) Daniel Mauvoisin et al.   PROTEOMICS

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells

(2013) Yinghua Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

A Circadian Clock Gene, Rev-erb , Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression

(2013) S. Sato et al.   JOURNAL OF IMMUNOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

TH17 Cell Differentiation Is Regulated by the Circadian Clock

(2013) X. Yu et al.   SCIENCE

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Modulation of the antitumor immune response by complement

(2008) Maciej M Markiewski et al.   NATURE IMMUNOLOGY