Hypoxia, metabolism, and the circadian clock: new links to overcome radiation resistance in high-grade gliomas
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Title
Hypoxia, metabolism, and the circadian clock: new links to overcome radiation resistance in high-grade gliomas
Authors
Keywords
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Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 39, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-07-07
DOI
10.1186/s13046-020-01639-2
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Note: Only part of the references are listed.- Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis
- (2020) Russel J. Reiter et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
- (2020) Peiwen Chen et al. Cancer Discovery
- Targeting Glioblastoma Stem Cells with 2-Deoxy-D-Glucose (2-DG) Potentiates Radiation-Induced Unfolded Protein Response (UPR)
- (2019) Sumedh Shah et al. Cancers
- Is it Time to Change Radiotherapy: The Dawning of Chronoradiotherapy?
- (2019) E. Harper et al. CLINICAL ONCOLOGY
- Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals
- (2019) Yaarit Adamovich et al. Cell Metabolism
- Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies
- (2019) Wai Hoong Chang et al. Journal of Translational Medicine
- Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism
- (2019) Amandine Verlande et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Cancer Stem Cells and Radioresistance: DNA Repair and Beyond
- (2019) Alexander Schulz et al. Cancers
- TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG)
- (2019) Coralie Werbrouck et al. CLINICAL CANCER RESEARCH
- Targeting reduced mitochondrial DNA quantity as a therapeutic approach in pediatric high-grade gliomas
- (2019) Han Shen et al. NEURO-ONCOLOGY
- Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock
- (2019) Zhen Dong et al. Cancer Discovery
- Cellular Stress Responses in Radiotherapy
- (2019) Kim et al. Cells
- Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway
- (2019) Pauline Deshors et al. Cell Death & Disease
- Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity
- (2019) Blandin et al. Cancers
- Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
- (2018) Zandra E. Walton et al. CELL
- Role of metabolism in cancer cell radioresistance and radiosensitization methods
- (2018) Le Tang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Endothelial trans-differentiation in glioblastoma recurring after radiotherapy
- (2018) Ivana De Pascalis et al. MODERN PATHOLOGY
- Hypoxia-activated evofosfamide for treatment of recurrent bevacizumab-refractory glioblastoma: a phase I surgical study
- (2018) Andrew Brenner et al. NEURO-ONCOLOGY
- Circadian regulator NR1D2 regulates glioblastoma cell proliferation and motility
- (2018) Min Yu et al. ONCOGENE
- Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
- (2018) Ludovic S. Mure et al. SCIENCE
- A proteomics landscape of circadian clock in mouse liver
- (2018) Yunzhi Wang et al. Nature Communications
- Ubiquitylation Dynamics of the Clock Cell Proteome and TIMELESS during a Circadian Cycle
- (2018) Áron Szabó et al. Cell Reports
- Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle
- (2018) Shogo Sato et al. Molecular Metabolism
- The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy
- (2018) Youqiong Ye et al. Cell Systems
- Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
- (2018) Gabriele Sulli et al. NATURE
- Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism
- (2018) Martin Benej et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Correlation between Deregulated Expression of PER2 Gene and Degree of Glioma Malignancy
- (2018) Fan Wang et al. TUMORI
- Irradiation of pediatric glioblastoma cells promotes radioresistance and enhances glioma malignancy via genome-wide transcriptome changes
- (2018) Hisham S. Alhajala et al. Oncotarget
- Genetic Variants Predict Optimal Timing of Radiotherapy to Reduce Side-effects in Breast Cancer Patients
- (2018) K. Johnson et al. CLINICAL ONCOLOGY
- A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes
- (2017) Minoru Kobayashi et al. FEBS Journal
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
- (2017) Peter W Stacpoole JNCI-Journal of the National Cancer Institute
- Circadian Alterations in a Murine Model of Hypothalamic Glioma
- (2017) José M. Duhart et al. Frontiers in Physiology
- Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
- (2016) Nicole M. Kettner et al. CANCER CELL
- Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis
- (2016) Carolina Alonso-González et al. CANCER LETTERS
- Circadian Rhythm Disruption Promotes Lung Tumorigenesis
- (2016) Thales Papagiannakopoulos et al. Cell Metabolism
- Differences in toxicity and outcome associated with circadian variations between patients undergoing daytime and evening radiotherapy for prostate adenocarcinoma
- (2016) Feng-Ming Hsu et al. CHRONOBIOLOGY INTERNATIONAL
- Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma
- (2016) K. Tateishi et al. CLINICAL CANCER RESEARCH
- CRY2 and FBXL3 Cooperatively Degrade c-MYC
- (2016) Anne-Laure Huber et al. MOLECULAR CELL
- The Warburg Effect: How Does it Benefit Cancer Cells?
- (2016) Maria V. Liberti et al. TRENDS IN BIOCHEMICAL SCIENCES
- Effects of melatonin on HIF-1α and VEGF expression and on the invasive properties of hepatocarcinoma cells
- (2016) JUCIMARA COLOMBO et al. Oncology Letters
- Hypoxia and metabolic adaptation of cancer cells
- (2016) K L Eales et al. Oncogenesis
- MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells
- (2015) Brian J. Altman et al. Cell Metabolism
- Night shift work, chronotype and prostate cancer risk in the MCC-Spain case-control study
- (2015) Kyriaki Papantoniou et al. INTERNATIONAL JOURNAL OF CANCER
- Citrate concentrations increase with hypoperfusion in pediatric diffuse intrinsic pontine glioma
- (2015) Kristen W. Yeom et al. JOURNAL OF NEURO-ONCOLOGY
- Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism
- (2015) H. Shen et al. MOLECULAR CANCER THERAPEUTICS
- Hypoxia disrupts the expression levels of circadian rhythm genes in hepatocellular carcinoma
- (2015) CHAO YU et al. Molecular Medicine Reports
- Mitochondrial induction as a potential radio-sensitizer in lung cancer cells - a short report
- (2015) Ronen Shavit et al. CELLULAR ONCOLOGY
- Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
- (2015) Niu Zhanfeng et al. Oncotarget
- Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment
- (2015) Vitalba Ruggieri et al. Oncotarget
- Deregulated Expression of the Per1 and Per2 in Human Gliomas
- (2014) He-chun Xia et al. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
- Advanced Magnetic Resonance Imaging of the Physical Processes in Human Glioblastoma
- (2014) Jayashree Kalpathy-Cramer et al. CANCER RESEARCH
- Comparison of acute skin reaction following morning versus late afternoon radiotherapy in patients with breast cancer who have undergone curative surgical resection
- (2014) J. M. Noh et al. JOURNAL OF RADIATION RESEARCH
- Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition
- (2014) Cecilie Abildgaard et al. Journal of Translational Medicine
- Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer
- (2014) F. W. Hunter et al. MOLECULAR CANCER THERAPEUTICS
- Metabolic consequences of timed feeding in mice
- (2014) Nurulaini Abu Shamsi et al. PHYSIOLOGY & BEHAVIOR
- A circadian gene expression atlas in mammals: Implications for biology and medicine
- (2014) Ray Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deregulated Expression of Cry1 and Cry2 in Human Gliomas
- (2013) Yong Luo et al. Asian Pacific Journal of Cancer Prevention
- Impact of time of day on outcomes after stereotactic radiosurgery for non-small cell lung cancer brain metastases
- (2013) Shahed N. Badiyan et al. CANCER
- Circadian pathway genes in relation to glioma risk and outcome
- (2013) Melissa H. Madden et al. CANCER CAUSES & CONTROL
- Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing’s sarcoma cells for apoptosis
- (2013) Mehtap Kilic-Eren et al. Cancer Cell International
- Reprogramming of the Circadian Clock by Nutritional Challenge
- (2013) Kristin L. Eckel-Mahan et al. CELL
- Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor-suppressive miR-124
- (2013) Aihua Li et al. FEBS LETTERS
- Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
- (2013) E. M. Dunbar et al. INVESTIGATIONAL NEW DRUGS
- Long-term safety of dichloroacetate in congenital lactic acidosis
- (2013) Monica Abdelmalak et al. MOLECULAR GENETICS AND METABOLISM
- Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo
- (2013) F. Zwicker et al. STRAHLENTHERAPIE UND ONKOLOGIE
- The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function
- (2012) L C J Baker et al. BRITISH JOURNAL OF CANCER
- Imaging hypoxia in gliomas
- (2012) I Mendichovszky et al. BRITISH JOURNAL OF RADIOLOGY
- Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis
- (2012) Christina Wanka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Function of carbonic anhydrase IX in glioblastoma multiforme
- (2012) M. A. Proescholdt et al. NEURO-ONCOLOGY
- Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expression Levels
- (2012) Inês Crespo et al. PLoS One
- The human circadian metabolome
- (2012) R. Dallmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Breast cancer among shift workers: results of the WOLF longitudinal cohort study
- (2012) Anders Knutsson et al. SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
- Hypoxia-related molecules HIF-1α, CA9, and osteopontin
- (2012) O.P. Erpolat et al. STRAHLENTHERAPIE UND ONKOLOGIE
- Deregulated Expression of the Clock Genes in Gliomas
- (2012) Zhijun Chen et al. TECHNOLOGY IN CANCER RESEARCH & TREATMENT
- Diffuse intrinsic pontine glioma: poised for progress
- (2012) Katherine E. Warren Frontiers in Oncology
- Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells
- (2011) Yunfei Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Control of skin cancer by the circadian rhythm
- (2011) S. Gaddameedhi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells
- (2011) Miguel A. Peña-Rico et al. RADIOTHERAPY AND ONCOLOGY
- Circadian variation in radiation-induced intestinal mucositis in patients with cervical carcinoma
- (2010) Pragya Shukla et al. CANCER
- Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: Is there a difference in outcome between morning and afternoon treatment?
- (2010) Douglas A. Rahn et al. CANCER
- AKT and TOR Signaling Set the Pace of the Circadian Pacemaker
- (2010) Xiangzhong Zheng et al. CURRENT BIOLOGY
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Radiation Resistance of Cancer Stem Cells: The 4 R's of Radiobiology Revisited
- (2010) Frank Pajonk et al. STEM CELLS
- STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect
- (2009) Sean P Pitroda et al. BMC Medicine
- Hypoxia and Radiation Therapy: Past History, Ongoing Research, and Future Promise
- (2009) Sara Rockwell et al. CURRENT MOLECULAR MEDICINE
- Oral mucositis in morning vs. evening irradiated patients: A randomised prospective study
- (2009) Manish Goyal et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects
- (2009) BS Dwarakanath et al. Journal of Cancer Research and Therapeutics
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- Circadian oscillation of nucleotide excision repair in mammalian brain
- (2009) Tae-Hong Kang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression
- (2009) Christopher Vollmers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glycolytic metabolism and tumour response to fractionated irradiation
- (2009) Ulrike G.A. Sattler et al. RADIOTHERAPY AND ONCOLOGY
- Comparison of Toxicity Associated With Early Morning Versus Late Afternoon Radiotherapy in Patients With Head-and-Neck Cancer: A Prospective Randomized Trial of the National Cancer Institute of Canada Clinical Trials Group (HN3)
- (2008) Georg A. Bjarnason et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Dichloroacetate (DCA) sensitizes both wild‐type and over expressingBcl‐2prostate cancer cells in vitro to radiation
- (2008) Wengang Cao et al. PROSTATE
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