3D gastruloids: a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation

Human gastrulation: The embryo and its models

(2021) Sabitri Ghimire et al.   DEVELOPMENTAL BIOLOGY

Synthetic by design: Exploiting tissue self-organization to explore early human embryology

(2021) Edwin A. Rosado-Olivieri et al.   DEVELOPMENTAL BIOLOGY

Gastruloid Development Competence Discriminates Different States of Pluripotency

(2021) Federica Cermola et al.   Stem Cell Reports

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

(2021) Xiaodong Liu et al.   NATURE

Blastocyst-like structures generated from human pluripotent stem cells

(2021) Leqian Yu et al.   NATURE

Self-organized signaling in stem cell models of embryos

(2021) Lizhong Liu et al.   Stem Cell Reports

Gastruloids generated without exogenous Wnt activation develop anterior neural tissues

(2021) Mehmet U. Girgin et al.   Stem Cell Reports

Biomedical and societal impacts of in vitro embryo models of mammalian development

(2021) Naomi Moris et al.   Stem Cell Reports

Axial elongation of caudalized human organoids mimics aspects of neural tube development

(2021) Ashley R. G. Libby et al.   DEVELOPMENT

Co-development of central and peripheral neurons with trunk mesendoderm in human elongating multi-lineage organized gastruloids

(2021) Zachary T. Olmsted et al.   Nature Communications

Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre

(2021) Peng-Fei Xu et al.   Nature Communications

Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines

(2021) Amander T. Clark et al.   Stem Cell Reports

ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update

(2021) Robin Lovell-Badge et al.   Stem Cell Reports

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

(2020) Susanne C. van den Brink et al.   NATURE

Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells

(2020) Insoo Hyun et al.   Stem Cell Reports

Modelling human embryogenesis: embryo-like structures spark ethical and policy debate

(2020) Ana M Pereira Daoud et al.   HUMAN REPRODUCTION UPDATE

An in vitro model of early anteroposterior organization during human development

(2020) Naomi Moris et al.   NATURE

Methoxyacetic acid inhibits histone deacetylase and impairs axial elongation morphogenesis of mouse gastruloids in a retinoic acid signaling‐dependent manner

(2020) Aileen S. W. Li et al.   Birth Defects Research

Phenotypic landscape of intestinal organoid regeneration

(2020) Ilya Lukonin et al.   NATURE

Reassembling gastrulation

(2020) Alexandra Schauer et al.   DEVELOPMENTAL BIOLOGY

Modeling mammalian trunk development in a dish

(2020) Jesse V. Veenvliet et al.   DEVELOPMENTAL BIOLOGY

Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro

(2020) Gianluca Amadei et al.   DEVELOPMENTAL CELL

Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells

(2020) Jonathon M. Muncie et al.   DEVELOPMENTAL CELL

Stem-cell-based embryo models for fundamental research and translation

(2020) Jianping Fu et al.   NATURE MATERIALS

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

(2020) Jesse V. Veenvliet et al.   SCIENCE

Capturing Cardiogenesis in Gastruloids

(2020) Giuliana Rossi et al.   Cell Stem Cell

Rethinking embryology in vitro: A synergy between engineering, data science and theory

(2020) Nicola Gritti et al.   DEVELOPMENTAL BIOLOGY

The endoderm: a divergent cell lineage with many commonalities

(2019) Sonja Nowotschin et al.   DEVELOPMENT

A 3D model of a human epiblast reveals BMP4-driven symmetry breaking

(2019) Mijo Simunovic et al.   NATURE CELL BIOLOGY

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells

(2019) Yusuke Marikawa et al.   REPRODUCTIVE TOXICOLOGY

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

Deconstructing and reconstructing the mouse and human early embryo

(2018) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Self-organization of a human organizer by combined Wnt and Nodal signalling

(2018) I. Martyn et al.   NATURE

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Debate ethics of embryo models from stem cells

(2018) Nicolas Rivron et al.   NATURE

Developmental toxicity assessment of common excipients using a stem cell-based in vitro morphogenesis model

(2017) Chloe J. Yuan et al.   FOOD AND CHEMICAL TOXICOLOGY

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Thalidomide-induced teratogenesis: History and mechanisms

(2015) Neil Vargesson   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Neuromesodermal progenitors and the making of the spinal cord

(2015) D. Henrique et al.   DEVELOPMENT

What if stem cells turn into embryos in a dish?

(2015) Martin F Pera et al.   NATURE METHODS

Brachyury cooperates with Wnt/β-catenin signalling to elicit primitive-streak-like behaviour in differentiating mouse embryonic stem cells

(2014) David A Turner et al.   BMC BIOLOGY

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

(2014) S. C. van den Brink et al.   DEVELOPMENT

Wnt/ -catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells

(2014) D. A. Turner et al.   DEVELOPMENT

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock

(2012) A. C. Oates et al.   DEVELOPMENT

Initiating head development in mouse embryos: integrating signalling and transcriptional activity

(2012) R. M. Arkell et al.   Open Biology

FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis

(2011) L. A. Naiche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

(2009) J. Rossant et al.   DEVELOPMENT

Aggregated P19 mouse embryonal carcinoma cells as a simple in vitro model to study the molecular regulations of mesoderm formation and axial elongation morphogenesis

(2009) Yusuke Marikawa et al.   GENESIS

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

Morphogenesis of the node and notochord: The cellular basis for the establishment and maintenance of left-right asymmetry in the mouse

(2008) Jeffrey D. Lee et al.   DEVELOPMENTAL DYNAMICS