Thalidomide-induced teratogenesis: History and mechanisms

Thalidomide (5HPP-33) Suppresses Microtubule Dynamics and Depolymerizes the Microtubule Network by Binding at the Vinblastine Binding Site on Tubulin

(2015) Aijaz Rashid et al.   BIOCHEMISTRY

Effect of maternal diabetes on the embryo, fetus, and children: Congenital anomalies, genetic and epigenetic changes and developmental outcomes

(2015) Asher Ornoy et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Inhibition of Endothelial Slit2/Robo1 Signaling by Thalidomide Restrains Angiogenesis by Blocking the PI3K/Akt Pathway

(2014) Yinan Li et al.   DIGESTIVE DISEASES AND SCIENCES

Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression

(2014) Xiaohan Zhao et al.   HUMAN MOLECULAR GENETICS

Thalidomide mimics uridine binding to an aromatic cage in cereblon

(2014) Marcus D. Hartmann et al.   JOURNAL OF STRUCTURAL BIOLOGY

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

(2014) Philip P Chamberlain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcriptomic Characterization of C57BL/6 Mouse Embryonic Stem Cell Differentiation and Its Modulation by Developmental Toxicants

(2014) Xiugong Gao et al.   PLoS One

Recognition of the phenotype of thalidomide embryopathy in countries endemic for leprosy

(2013) Fernanda S.L. Vianna et al.   CLINICAL DYSMORPHOLOGY

Disruption of the Cereblon Gene Enhances Hepatic AMPK Activity and Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice

(2013) K. M. Lee et al.   DIABETES

Molecular analysis of regulative events in the developing chick limb

(2013) Chris Mahony et al.   JOURNAL OF ANATOMY

Thalidomide-induced angiopoietin 2, Notch1 and Dll4 downregulation under hypoxic condition in tissues with gastrointestinal vascular malformation and human umbilical vein endothelial cells

(2013) Qian Feng et al.   Journal of Digestive Diseases

Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration

(2013) Nick R. Love et al.   NATURE CELL BIOLOGY

Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

(2013) C. Mahony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

(2013) J. Kronke et al.   SCIENCE

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

(2013) G. Lu et al.   SCIENCE

Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells

(2012) Kesavan Meganathan et al.   PLoS One

Redox control of teratogenesis

(2012) Jason M. Hansen et al.   REPRODUCTIVE TOXICOLOGY

Nitric oxide rescues thalidomide mediated teratogenicity

(2012) Jamila H. Siamwala et al.   Scientific Reports

The non-redundant function of cohesin acetyltransferase Esco2

(2012) Gabriela Whelan et al.   Nucleus

Genome-wide analysis of gene expression during Xenopus tropicalis tadpole tail regeneration

(2011) Nick R Love et al.   BMC DEVELOPMENTAL BIOLOGY

Teratogenic effects of thalidomide: molecular mechanisms

(2011) Takumi Ito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

What can we learn from the thalidomide experience

(2011) Marilyn T. Miller et al.   CURRENT OPINION IN OPHTHALMOLOGY

Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)-dependent, reactive oxygen species (ROS)-mediated mechanism

(2011) Crystal J. J. Lee et al.   FASEB JOURNAL

A Zebrafish Model of Roberts Syndrome Reveals That Esco2 Depletion Interferes with Development by Disrupting the Cell Cycle

(2011) Maren Mönnich et al.   PLoS One

Racemates revisited: heterochiral assemblies and the example ofdl-thalidomide

(2011) David E. Hague et al.   XENOBIOTICA

Apoptosis Induction by Thalidomide: Critical for Limb Teratogenicity but Therapeutic Potential in Idiopathic Pulmonary Fibrosis?

(2011) Jurgen Knobloch et al.   Current Molecular Pharmacology

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia

(2010) Franck Lebrin et al.   NATURE MEDICINE

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Thalidomide-induced limb defects: resolving a 50-year-old puzzle

(2009) Neil Vargesson   BIOESSAYS

Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected

(2009) Marilyn T. Miller et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Thalidomide attenuates nitric oxide-driven angiogenesis by interacting with soluble guanylyl cyclase

(2009) Syamantak Majumder et al.   BRITISH JOURNAL OF PHARMACOLOGY

History, heresy and radiology in scientific discovery

(2009) J McCredie   Journal of Medical Imaging and Radiation Oncology

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

(2009) C. Therapontos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide☆

(2009) Makoto Ema et al.   REPRODUCTIVE TOXICOLOGY

Oxidative Stress in Developmental Origins of Disease: Teratogenesis, Neurodevelopmental Deficits, and Cancer

(2009) Peter G. Wells et al.   TOXICOLOGICAL SCIENCES

Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning

(2008) Francesca V. Mariani et al.   NATURE