Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

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A tensile ring drives tissue flows to shape the gastrulating amniote embryo

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Molecular anatomy of the pre-primitive-streak chick embryo

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Basement membrane remodelling regulates mouse embryogenesis

(2020) Christos Kyprianou et al.   NATURE

A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells

(2019) Iain Martyn et al.   DEVELOPMENT

A 3D model of a human epiblast reveals BMP4-driven symmetry breaking

(2019) Mijo Simunovic et al.   NATURE CELL BIOLOGY

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells

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Self-organization of stem cells into embryos: A window on early mammalian development

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Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells

(2019) Susan Eliazer et al.   Cell Stem Cell

Prediction and control of symmetry breaking in embryoid bodies by environment and signal integration

(2019) Naor Sagy et al.   DEVELOPMENT

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

ilastik: interactive machine learning for (bio)image analysis

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Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids

(2019) Sapna Chhabra et al.   PLOS BIOLOGY

High-throughput micropatterning platform reveals Nodal-dependent bisection of peri-gastrulation–associated versus preneurulation-associated fate patterning

(2019) Mukul Tewary et al.   PLOS BIOLOGY

Third-generationin situhybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust

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Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity

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Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

Deconstructing and reconstructing the mouse and human early embryo

(2018) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells

(2018) Xufeng Xue et al.   NATURE MATERIALS

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

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Geometrical confinement controls the asymmetric patterning of brachyury in cultures of pluripotent cells

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Cytoskeletal tension regulates mesodermal spatial organization and subsequent vascular fate

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Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

Mechanics of neurulation: From classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube

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Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Monitoring developmental force distributions in reconstituted embryonic epithelia

(2016) L. Przybyla et al.   METHODS

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Interfacial geometry dictates cancer cell tumorigenicity

(2016) Junmin Lee et al.   NATURE MATERIALS

The tissue mechanics of vertebrate body elongation and segmentation

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Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Desktop aligner for fabrication of multilayer microfluidic devices

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Mechanics of tissue compaction

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Role of physical forces in embryonic development

(2015) Hiroshi Hamada   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Morphomechanics: transforming tubes into organs

(2014) Larry A Taber   CURRENT OPINION IN GENETICS & DEVELOPMENT

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

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A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Local cell interactions and self-amplifying individual cell ingression drive amniote gastrulation

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On the role of intrinsic and extrinsic forces in early cardiac S-looping

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Multiplex Genome Engineering Using CRISPR/Cas Systems

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Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

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Fiji: an open-source platform for biological-image analysis

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Spatial organization of the extracellular matrix regulates cell-cell junction positioning

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A Positive Role of Cadherin in Wnt/β-Catenin Signalling during Epithelial-Mesenchymal Transition

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Geometric cues for directing the differentiation of mesenchymal stem cells

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Wnt Signaling and the Polarity of the Primary Body Axis

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Towards an integrated view of Wnt signaling in development

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Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Live imaging of cell protrusive activity, and extracellular matrix assembly and remodeling during morphogenesis in the frog, Xenopus laevis

(2008) Lance A. Davidson et al.   DEVELOPMENTAL DYNAMICS