Methoxyacetic acid inhibits histone deacetylase and impairs axial elongation morphogenesis of mouse gastruloids in a retinoic acid signaling‐dependent manner

Application of a human mesoderm tissue elongation system in vitro derived from human induced pluripotent stem cells to risk assessment for teratogenic chemicals

(2020) Hiromasa Ninomiya et al.   CHEMOSPHERE

Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells

(2019) Yusuke Marikawa et al.   REPRODUCTIVE TOXICOLOGY

Fluoxetine Inhibits Canonical Wnt Signaling to Impair Embryoid Body Morphogenesis: Potential Teratogenic Mechanisms of a Commonly Used Antidepressant

(2018) Erica L L Warkus et al.   TOXICOLOGICAL SCIENCES

Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans -resveratrol

(2018) Iris Q. Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Developmental toxicity assessment of common excipients using a stem cell-based in vitro morphogenesis model

(2017) Chloe J. Yuan et al.   FOOD AND CHEMICAL TOXICOLOGY

Retinoic acid in developmental toxicology: Teratogen, morphogen and biomarker

(2017) Aldert H. Piersma et al.   REPRODUCTIVE TOXICOLOGY

Exposure-Based Validation of an In Vitro Gastrulation Model for Developmental Toxicity Assays

(2017) Erica L. L. Warkus et al.   TOXICOLOGICAL SCIENCES

In Vitro Micropatterned Human Pluripotent Stem Cell Test (µP-hPST) for Morphometric-Based Teratogen Screening

(2017) Jiangwa Xing et al.   Scientific Reports

A standardized human embryoid body platform for the detection and analysis of teratogens

(2017) Anthony Flamier et al.   PLoS One

Adverse effect of valproic acid on an in vitro gastrulation model entails activation of retinoic acid signaling

(2016) Aileen S.W. Li et al.   REPRODUCTIVE TOXICOLOGY

Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs

(2015) France-Hélène Paradis et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Phthalate Concentrations in Personal Care Products and the Cumulative Exposure to Female Adults and Infants in Shanghai

(2015) Jiaqin Bao et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

An in vitro gastrulation model recapitulates the morphogenetic impact of pharmacological inhibitors of developmental signaling pathways

(2015) Aileen S. W. Li et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis

(2015) Elisa C.M. Tonk et al.   REPRODUCTIVE TOXICOLOGY

Use ofIn VitroMorphogenesis of Mouse Embryoid Bodies to Assess Developmental Toxicity of Therapeutic Drugs Contraindicated in Pregnancy

(2015) Erica L. L. Warkus et al.   TOXICOLOGICAL SCIENCES

Effects of Ethylene Glycol Monomethyl Ether and Its Metabolite, 2-Methoxyacetic Acid, on Organogenesis Stage Mouse Limbs In Vitro

(2014) Caroline Dayan et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Exposure-Based Validation List for Developmental Toxicity Screening Assays

(2014) George P. Daston et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

(2014) S. C. van den Brink et al.   DEVELOPMENT

Retinoic Acid and Histone Deacetylases Regulate Epigenetic Changes in Embryonic Stem Cells

(2014) Alison M. Urvalek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil

(2014) Caroline G.Y. Lau et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Establishment and Assessment of a New Human Embryonic Stem Cell-Based Biomarker Assay for Developmental Toxicity Screening

(2013) Jessica A. Palmer et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

A High-Throughput Screen for Teratogens Using Human Pluripotent Stem Cells

(2013) Sei Kameoka et al.   TOXICOLOGICAL SCIENCES

Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

(2011) Torbjörn Tomson et al.   LANCET NEUROLOGY

Teratogen screening using transcriptome profiling of differentiating human embryonic stem cells

(2010) Yoav Mayshar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations

(2010) Janneke Jentink et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics

(2010) Paul R. West et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Aggregated P19 mouse embryonal carcinoma cells as a simple in vitro model to study the molecular regulations of mesoderm formation and axial elongation morphogenesis

(2009) Yusuke Marikawa et al.   GENESIS

Assessment of drug induced developmental toxicity using human embryonic stem cells

(2008) A MEHTA et al.   CELL BIOLOGY INTERNATIONAL

Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton

(2008) E. T. Shifley et al.   DEVELOPMENT

Interactions of methoxyacetic acid with androgen receptor

(2008) Gargi Bagchi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY