Apoptotic cell signals and heterogeneity in macrophage function: Fine-tuning for a healthy liver

Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death

(2020) Maria C. Tanzer et al.   Cell Reports

Metabolites released from apoptotic cells act as tissue messengers

(2020) Christopher B. Medina et al.   NATURE

Runx3 prevents spontaneous colitis by directing the differentiation of anti-inflammatory mononuclear phagocytes

(2020) Shay Hantisteanu et al.   PLoS One

Macrophages Use Distinct Actin Regulators to Switch Engulfment Strategies and Ensure Phagocytic Plasticity In Vivo

(2020) Andrew J. Davidson et al.   Cell Reports

Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer

(2020) Anna Zagórska et al.   Life Science Alliance

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage

(2019) Stefan Uderhardt et al.   CELL

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

(2019) Freya R. Svedberg et al.   NATURE IMMUNOLOGY

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis

(2019) Sara Zumerle et al.   Cell Reports

Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPKα Pathway in Macrophages

(2019) Wen Liu et al.   JOURNAL OF IMMUNOLOGY

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

(2019) Mashito Sakai et al.   IMMUNITY

Commensal microbiota drive the functional diversification of colon macrophages

(2019) Byunghyun Kang et al.   Mucosal Immunology

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease

(2019) Andrea Kristina Horst et al.   Frontiers in Immunology

The evolution of spherical cell shape; progress and perspective

(2019) Paul Richard Jesena Yulo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs

(2018) Xing Liu et al.   CELL

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

(2018) Tovah N. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tissue-specific Role of CX3CR1 Expressing Immune Cells and Their Relationships with Human Disease

(2018) Myoungsoo Lee et al.   Immune Network

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

(2018) Sebastiaan De Schepper et al.   CELL

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

(2017) Evangelos Triantafyllou et al.   GUT

The Cytokine TGF-β Promotes the Development and Homeostasis of Alveolar Macrophages

(2017) Xueyang Yu et al.   IMMUNITY

Involvement of adenosine A3 receptors in the chemotactic navigation of macrophages towards apoptotic cells

(2017) Gergely Joós et al.   IMMUNOLOGY LETTERS

MAPK/p38 regulation of cytoskeleton rearrangement accelerates induction of macrophage activation by TLR4, but not TLR3

(2017) Hongjun Bian et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Phagocytosis imprints heterogeneity in tissue-resident macrophages

(2017) Noelia A-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

(2017) Lara Campana et al.   JOURNAL OF IMMUNOLOGY

Selective Biological Responses of Phagocytes and Lungs to Purified Histones

(2017) Fatemeh Fattahi et al.   Journal of Innate Immunity

The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition

(2017) Hui-Qiong He et al.   MOLECULES

Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling

(2017) A Schridde et al.   Mucosal Immunology

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

(2017) Carlos M. Minutti et al.   SCIENCE

Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis

(2017) Mirko Dengler et al.   Oncotarget

Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages

(2017) Antimo Cutone et al.   Frontiers in Immunology

Anti-inflammatory Mechanisms Triggered by Apoptotic Cells during Their Clearance

(2017) Zsuzsa Szondy et al.   Frontiers in Immunology

SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress

(2017) Daniel A. Patten et al.   Scientific Reports

Corpse Engulfment Generates a Molecular Memory that Primes the Macrophage Inflammatory Response

(2016) Helen Weavers et al.   CELL

Do not let death do us part: ‘find-me’ signals in communication between dying cells and the phagocytes

(2016) C B Medina et al.   CELL DEATH AND DIFFERENTIATION

Exposure of phosphatidylserine on the cell surface

(2016) S Nagata et al.   CELL DEATH AND DIFFERENTIATION

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice

(2016) Bruna Araujo David et al.   GASTROENTEROLOGY

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

CX3CR1 deficiency attenuates imiquimod-induced psoriasis-like skin inflammation with decreased M1 macrophages

(2016) Sohshi Morimura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis

(2016) David M. Richards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury

(2016) Pia Rantakari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses

(2016) Javier Mora et al.   Journal of Molecular Cell Biology

Apoptotic Cells Release IL1 Receptor Antagonist in Response to Genotoxic Stress

(2016) J. Y. Chwee et al.   Cancer Immunology Research

TAM Receptor Signaling in Immune Homeostasis

(2015) Carla V. Rothlin et al.   Annual Review of Immunology

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells

(2015) Jianpeng Sheng et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Changes in Lipid Composition During Manganese-Induced Apoptosis in PC12 Cells

(2015) P. A. Corsetto et al.   NEUROCHEMICAL RESEARCH

CD300f associates with IL-4 receptor α and amplifies IL-4–induced immune cell responses

(2015) Itay Moshkovits et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Specific Signals Control Reversible Program of Localization and Functional Polarization of Macrophages

(2014) Yasutaka Okabe et al.   CELL

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages

(2014) Malay Haldar et al.   CELL

T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury

(2014) Haofeng Ji et al.   HEPATOLOGY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Adenosine A3 receptors negatively regulate the engulfment-dependent apoptotic cell suppression of inflammation

(2014) Edina Duró et al.   IMMUNOLOGY LETTERS

Toll-Like Receptor-Triggered Calcium Mobilization Protects Mice against Bacterial Infection through Extracellular ATP Release

(2014) Hua Ren et al.   INFECTION AND IMMUNITY

Macrophages Engulfing Apoptotic Cells Produce Nonclassical Retinoids To Enhance Their Phagocytic Capacity

(2014) Z. Sarang et al.   JOURNAL OF IMMUNOLOGY

Extracellular Adenosine Triphosphate Affects the Response of Human Macrophages Infected With Mycobacterium tuberculosis

(2014) Nicolas Dubois-Colas et al.   JOURNAL OF INFECTIOUS DISEASES

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Molecular mechanism for differential recognition of membrane phosphatidylserine by the immune regulatory receptor Tim4

(2014) G. T. Tietjen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling

(2014) C. Ishifune et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells

(2014) Hiroshi Yamaguchi et al.   eLife

Cathepsin S generates soluble CX3CL1 (fractalkine) in vascular smooth muscle cells

(2013) Urša Pečar Fonović et al.   BIOLOGICAL CHEMISTRY

Phagocytosis Dynamics Depends on Target Shape

(2013) Debjani Paul et al.   BIOPHYSICAL JOURNAL

Identification of a Tissue-Specific, C/EBP -Dependent Pathway of Differentiation for Murine Peritoneal Macrophages

(2013) D. W. Cain et al.   JOURNAL OF IMMUNOLOGY

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells

(2013) Gretchen E. Diehl et al.   NATURE

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

(2013) Zaida G Ramirez-Ortiz et al.   NATURE IMMUNOLOGY

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

(2013) Noelia A-Gonzalez et al.   NATURE IMMUNOLOGY

Development of a Spontaneous Liver Disease Resembling Autoimmune Hepatitis in Mice Lacking Tyro3, Axl and Mer Receptor Tyrosine Kinases

(2013) Nan Qi et al.   PLoS One

Effects of Microparticle Size and Fc Density on Macrophage Phagocytosis

(2013) Patricia Pacheco et al.   PLoS One

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

(2013) Fenila Jacob et al.   Purinergic Signalling

Wrapping of ellipsoidal nano-particles by fluid membranes

(2013) Sabyasachi Dasgupta et al.   Soft Matter

Role for membrane remodeling in cell death: Implication for health and disease

(2013) Xavier Tekpli et al.   TOXICOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation

(2012) H. Qin et al.   JOURNAL OF IMMUNOLOGY

The Race to the Pole: How High-Aspect Ratio Shape and Heterogeneous Environments Limit Phagocytosis of Filamentous Escherichia coli Bacteria by Macrophages

(2012) Jens Möller et al.   NANO LETTERS

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Differential Macrophage Activation Alters the Expression Profile of NTPDase and Ecto-5′-Nucleotidase

(2012) Rafael Fernandes Zanin et al.   PLoS One

Retinoids produced by macrophages engulfing apoptotic cells contribute to the appearance of transglutaminase 2 in apoptotic thymocytes

(2011) Éva Garabuczi et al.   AMINO ACIDS

Involvement of Adenosine A2A Receptors in Engulfment-Dependent Apoptotic Cell Suppression of Inflammation

(2011) K. Koroskenyi et al.   JOURNAL OF IMMUNOLOGY

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling

(2010) Danute Pupjalis et al.   EMBO Molecular Medicine

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis

(2010) Paola Maderna et al.   FASEB JOURNAL

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages

(2010) Camila Marques-da-Silva et al.   IMMUNOBIOLOGY

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

(2010) Kodi S. Ravichandran   JOURNAL OF EXPERIMENTAL MEDICINE

Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor   or Retinoid X Receptor   Deficiency

(2010) T. Roszer et al.   JOURNAL OF IMMUNOLOGY

Coordination of Fc receptor signaling regulates cellular commitment to phagocytosis

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

(2010) M. Kronlage et al.   Science Signaling

Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis

(2009) Eleonora Patsenker et al.   HEPATOLOGY

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages

(2009) S.-Y. Park et al.   JOURNAL OF CELL SCIENCE

Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis

(2009) Tal Burstyn-Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Innate apoptotic immunity: the calming touch of death

(2008) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A

(2008) S. Courtney Frasch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

(2008) Masako Kohyama et al.   NATURE