Bile Acids, Their Receptors, and the Gut Microbiota

Of mice and men: Murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism

(2020) Sara Straniero et al.   JOURNAL OF LIPID RESEARCH

Global chemical effects of the microbiome include new bile-acid conjugations

(2020) Robert A. Quinn et al.   NATURE

Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease

(2020) Aze Wilson et al.   Scientific Reports

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

(2020) Clarissa Campbell et al.   NATURE

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis

(2020) Tae Gyu Oh et al.   Cell Metabolism

Gut Microbiota in Liver Disease: What Do We Know and What Do We Not Know?

(2020) Lu Jiang et al.   PHYSIOLOGY

Fecal metagenomics and metabolomics reveal gut microbial changes after bariatric surgery

(2020) Danxia Yu et al.   Surgery for Obesity and Related Diseases

Bile acids drive the newborn’s gut microbiota maturation

(2020) N. van Best et al.   Nature Communications

Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

(2020) Chun Chen et al.   Science Advances

Vitamin D Receptor Protects Against Dysbiosis and Tumorigenesis via the JAK/STAT Pathway in Intestine

(2020) Yong-Guo Zhang et al.   Cellular and Molecular Gastroenterology and Hepatology

Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time

(2019) Pieter de Groot et al.   GUT

Metagenomic analysis of bile salt biotransformation in the human gut microbiome

(2019) Promi Das et al.   BMC GENOMICS

A Human-like Bile Acid Pool Induced by Deletion of Cyp2c70 Modulates Effects of Farnesoid X Receptor Activation in Mice

(2019) Jan Freark de Boer et al.   JOURNAL OF LIPID RESEARCH

Regulations of bile acid metabolism in mouse models with hydrophobic bile acid composition

(2019) Akira Honda et al.   JOURNAL OF LIPID RESEARCH

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Gut microbiota modulate T cell trafficking into human colorectal cancer

(2018) Eleonora Cremonesi et al.   GUT

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls

(2018) Yanan Qiao et al.   Scientific Reports

The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism

(2018) Sarah Just et al.   Microbiome

FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid

(2018) Elliot S. Friedman et al.   GASTROENTEROLOGY

Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery

(2018) Vance L. Albaugh et al.   GASTROENTEROLOGY

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

(2017) Jan Freark de Boer et al.   GASTROENTEROLOGY

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

(2017) Na Jiao et al.   GUT

Bile acids and colon cancer: Is FXR the solution of the conundrum?

(2017) Raffaella Maria Gadaleta et al.   MOLECULAR ASPECTS OF MEDICINE

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

(2017) Anna V. Golubeva et al.   EBioMedicine

Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation

(2017) Lili Sheng et al.   Scientific Reports

Interaction of gut microbiota with bile acid metabolism and its influence on disease states

(2016) Christopher Staley et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

(2016) Cen Xie et al.   DIABETES

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

(2016) Frank J. Gonzalez et al.   GASTROENTEROLOGY

A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

(2016) Amon Asgharpour et al.   JOURNAL OF HEPATOLOGY

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

(2016) Shogo Takahashi et al.   JOURNAL OF LIPID RESEARCH

Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota

(2016) Annika Wahlström et al.   JOURNAL OF LIPID RESEARCH

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

(2016) Jun Wang et al.   NATURE GENETICS

Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission

(2016) Rinki Murphy et al.   OBESITY SURGERY

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

(2016) K. S. Kim et al.   SCIENCE

Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery

(2016) Katherine Nutsch et al.   Cell Reports

Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease

(2016) Marialena Mouzaki et al.   PLoS One

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

Lack of Vitamin D Receptor Causes Dysbiosis and Changes the Functions of the Murine Intestinal Microbiome

(2015) Dapeng Jin et al.   CLINICAL THERAPEUTICS

Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids

(2015) Vance L. Albaugh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Gut microbiota and liver diseases

(2015) Masami Minemura   WORLD JOURNAL OF GASTROENTEROLOGY

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery

(2015) Charles Robb Flynn et al.   Nature Communications

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

(2015) Jorge C. Correia et al.   Molecular Metabolism

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

(2014) D.-H. Kim et al.   EMBO JOURNAL

MECHANISMS IN ENDOCRINOLOGY: Bile acid sequestrants in type 2 diabetes: potential effects on GLP1 secretion

(2014) David P Sonne et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions

(2014) W. Zheng et al.   GENES & DEVELOPMENT

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

Beyond intestinal soap—bile acids in metabolic control

(2014) Folkert Kuipers et al.   Nature Reviews Endocrinology

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells

(2014) Guiyu Lou et al.   PLoS One

Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice

(2014) Marije Boesjes et al.   PLoS One

Bacterial Bile Metabolising Gene Abundance in Crohn's, Ulcerative Colitis and Type 2 Diabetes Metagenomes

(2014) Alain Labbé et al.   PLoS One

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

(2014) Chiara Degirolamo et al.   Cell Reports

The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate

(2013) Per-Arne Svensson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition

(2013) Javier Vaquero et al.   BIOCHEMICAL PHARMACOLOGY

Gastrectomy Increases the Expression of Hepatic Cytochrome P450 3A by Increasing Lithocholic Acid-Producing Enteric Bacteria in Mice

(2013) Makoto Ishii et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

(2013) Aleksandar D. Kostic et al.   Cell Host & Microbe

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells

(2013) A. M. Habib et al.   DIABETOLOGIA

Nuclear receptors in bile acid metabolism

(2013) Tiangang Li et al.   DRUG METABOLISM REVIEWS

A Surgical Model in Male Obese Rats Uncovers Protective Effects of Bile Acids Post-Bariatric Surgery

(2013) Rohit Kohli et al.   ENDOCRINOLOGY

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Obesity and colorectal cancer

(2013) Marc Bardou et al.   GUT

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

(2013) Noémie Péan et al.   HEPATOLOGY

Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)

(2013) Wahiba Berrabah et al.   HEPATOLOGY

Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity

(2013) N N Ahmad et al.   INTERNATIONAL JOURNAL OF OBESITY

Contribution of the 7β-hydroxysteroid dehydrogenase fromRuminococcus gnavusN53 to ursodeoxycholic acid formation in the human colon

(2013) Ja-Young Lee et al.   JOURNAL OF LIPID RESEARCH

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Co-occurrence of anaerobic bacteria in colorectal carcinomas

(2013) René L Warren et al.   Microbiome

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids

(2012) Lotta K. Stenman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

(2012) Senthilkumar Rajagopal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats

(2012) B. P. Cummings et al.   Disease Models & Mechanisms

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma

(2012) Yuan Chen et al.   HEPATOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: implications for host-microbe interactions contributing to obesity

(2012) A. N. Payne et al.   Obesity Reviews

Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1

(2011) Alex Odermatt et al.   BIOCHEMICAL JOURNAL

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers

(2011) Tingting Wang et al.   ISME Journal

Obesity, inflammation, and liver cancer

(2011) Beicheng Sun et al.   JOURNAL OF HEPATOLOGY

FXR and PXR: Potential therapeutic targets in cholestasis

(2011) Johan W. Jonker et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

(2011) Tingting Li et al.   MOLECULAR ENDOCRINOLOGY

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities

(2010) Rohit Kohli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D

(2010) Daniel R. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Bile Acid Metabolism in Childhood Functional Constipation: Inactivation of Secretory Bile Acids by Sulfation in a Subset of Patients

(2010) Alan F Hofmann et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

(2010) D. P. Poole et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Metabolic Effects of Fructose and the Worldwide Increase in Obesity

(2010) Luc Tappy et al.   PHYSIOLOGICAL REVIEWS

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

(2009) Jongsook Kim Kemper et al.   Cell Metabolism

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome

(2009) C. H. KIM et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

(2009) Marie A. Hildebrandt et al.   GASTROENTEROLOGY

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Serum bile acid along with plasma incretins and serum high–molecular weight adiponectin levels are increased after bariatric surgery

(2009) Hiroshi Nakatani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

(2009) Mary-Elizabeth Patti et al.   Obesity

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

(2009) Joshua M. Uronis et al.   PLoS One

Intestinal Microbiota Regulate Xenobiotic Metabolism in the Liver

(2009) Britta Björkholm et al.   PLoS One

Circadian Dysregulation Disrupts Bile Acid Homeostasis

(2009) Ke Ma et al.   PLoS One

Human gut microbiota in obesity and after gastric bypass

(2009) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease

(2009) Carsten Gnewuch et al.   WORLD JOURNAL OF GASTROENTEROLOGY

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

(2009) Gwendal Le Martelot et al.   PLOS BIOLOGY

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development

(2008) R. R.M. Maran et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phosphorylation of Farnesoid X Receptor by Protein Kinase C Promotes Its Transcriptional Activity

(2008) Romain Gineste et al.   MOLECULAR ENDOCRINOLOGY

Mini-Review: Endocrine Actions of Fibroblast Growth Factor 19

(2008) Stacey Jones   MOLECULAR PHARMACEUTICS

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA