Bile Acids, Their Receptors, and the Gut Microbiota

Bile acids (BAs) are a family of hydroxylated steroids secreted by the liver that aid in the breakdown and absorption of dietary fats. BAs also function as nutrient and inflammatory signaling molecules, acting through cognate receptors, to coordinate host metabolism. Commensal bacteria in the gastrointestinal tract are functional modifiers of the BA pool, affecting composition and abundance. Deconjugation of host BAs creates a molecular network that inextricably links gut microtia with their host. In this review we highlight the roles of BAs in mediating this mutualistic relationship with a focus on those events that impact host physiology and metabolism.

Automated summary

Bile acids, secreted by the liver, aid in the breakdown and absorption of dietary fats and also act as nutrient and inflammatory signaling molecules. Commensal bacteria in the gut can modify the composition and abundance of the bile acid pool, linking gut microbiota with their host.