The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation

(2012) Jae-Hwi Jang et al.   HEPATOLOGY

Bile acid profiling in human biological samples: Comparison of extraction procedures and application to normal and cholestatic patients

(2012) Lydie Humbert et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

(2011) Salvatore Modica et al.   GASTROENTEROLOGY

A biliary HCO3−umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes

(2011) Simon Hohenester et al.   HEPATOLOGY

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

(2011) Tingting Li et al.   MOLECULAR ENDOCRINOLOGY

Dose-Response of Five Bile Acids on Serum and Liver Bile Acid Concentrations and Hepatotoxicty in Mice

(2011) Peizhen Song et al.   TOXICOLOGICAL SCIENCES

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

(2010) Thijs W.H. Pols et al.   JOURNAL OF HEPATOLOGY

Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis

(2010) Isabelle Doignon et al.   JOURNAL OF HEPATOLOGY

Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATPchannels

(2010) Brigitte Lavoie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice

(2009) Iván L. Csanaky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Mouse organic solute transporter α deficiency enhances renal excretion of bile acids and attenuates cholestasis

(2009) Carol J. Soroka et al.   HEPATOLOGY

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

(2009) Verena Keitel et al.   HEPATOLOGY

ATP release after partial hepatectomy regulates liver regeneration in the rat

(2009) Emmanuel Gonzales et al.   JOURNAL OF HEPATOLOGY

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis

(2008) Young Joo Park et al.   HEPATOLOGY

A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice

(2008) Claudia Mitchell et al.   Nature Protocols