WNK1 is an assembly factor for the human ER membrane protein complex

Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly

(2021) Matilde Bertolini et al.   SCIENCE

Squaring the EMC – how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis

(2020) Norbert Volkmar et al.   JOURNAL OF CELL SCIENCE

Structural basis for membrane insertion by the human ER membrane protein complex

(2020) Tino Pleiner et al.   SCIENCE

Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex

(2020) Alison J. Inglis et al.   Cell Reports

The architecture of EMC reveals a path for membrane protein insertion

(2020) John P O'Donnell et al.   eLife

Structure of the ER membrane complex, a transmembrane-domain insertase

(2020) Lin Bai et al.   NATURE

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

(2020) Lakshmi E Miller-Vedam et al.   eLife

The Role of EMC during Membrane Protein Biogenesis

(2019) Patrick J. Chitwood et al.   TRENDS IN CELL BIOLOGY

Engineered SUMO/protease system identifies Pdr6 as a bidirectional nuclear transport receptor

(2019) Arturo Vera Rodriguez et al.   JOURNAL OF CELL BIOLOGY

The ER Membrane Protein Complex Promotes Biogenesis of Dengue and Zika Virus Non-structural Multi-pass Transmembrane Proteins to Support Infection

(2019) David L. Lin et al.   Cell Reports

Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis

(2019) Nicholas J. Barrows et al.   Scientific Reports

Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex

(2019) Songhai Tian et al.   Cell Reports

The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins

(2019) Ashley M Ngo et al.   eLife

Pharmacogenomics of GPCR Drug Targets

(2018) Alexander S. Hauser et al.   CELL

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

Quality Control of Orphaned Proteins

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

(2018) Ayala Shiber et al.   NATURE

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis

(2018) Norbert Volkmar et al.   JOURNAL OF CELL SCIENCE

A toolbox of anti–mouse and anti–rabbit IgG secondary nanobodies

(2017) Tino Pleiner et al.   JOURNAL OF CELL BIOLOGY

Mechanistic basis for a molecular triage reaction

(2017) Sichen Shao et al.   SCIENCE

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

UBE2O remodels the proteome during terminal erythroid differentiation

(2017) Anthony T. Nguyen et al.   SCIENCE

UBE2O is a quality control factor for orphans of multiprotein complexes

(2017) Kota Yanagitani et al.   SCIENCE

Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases

(2016) Juliette Hadchouel et al.   Annual Review of Physiology

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

(2016) Erik McShane et al.   CELL

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

(2016) Eisuke Itakura et al.   MOLECULAR CELL

Proteome complexity and the forces that drive proteome imbalance

(2016) J. Wade Harper et al.   NATURE

Small-molecule WNK inhibition regulates cardiovascular and renal function

(2016) Ken Yamada et al.   Nature Chemical Biology

VRACs and other ion channels and transporters in the regulation of cell volume and beyond

(2016) Thomas J. Jentsch   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

(2016) Jonathan L. Schmid-Burgk et al.   Nature Communications

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

(2016) Min-Kyung Sung et al.   eLife

The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation

(2016) Yue Xu et al.   Cell Discovery

Structure, Dynamics, Assembly, and Evolution of Protein Complexes

(2015) Joseph A. Marsh et al.   Annual Review of Biochemistry

Operon structure and cotranslational subunit association direct protein assembly in bacteria

(2015) Y.-W. Shieh et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

(2015) Takunori Satoh et al.   eLife

Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation

(2015) Tino Pleiner et al.   eLife

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

(2014) Gene-Wei Li et al.   CELL

Aneuploidy: implications for protein homeostasis and disease

(2014) A. B. Oromendia et al.   Disease Models & Mechanisms

A new set of highly efficient, tag-cleaving proteases for purifying recombinant proteins

(2014) Steffen Frey et al.   JOURNAL OF CHROMATOGRAPHY A

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

(2014) D. R. Alessi et al.   Science Signaling

Listerin-Dependent Nascent Protein Ubiquitination Relies on Ribosome Subunit Dissociation

(2013) Sichen Shao et al.   MOLECULAR CELL

Control of Protein Quality and Stoichiometries by N-Terminal Acetylation and the N-End Rule Pathway

(2013) Anna Shemorry et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Functional Expression of Human NKCC1 from a Synthetic Cassette-Based cDNA: Introduction of Extracellular Epitope Tags and Removal of Cysteines

(2013) Suma Somasekharan et al.   PLoS One

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

Defining human ERAD networks through an integrative mapping strategy

(2011) John C. Christianson et al.   NATURE CELL BIOLOGY

Widespread Cotranslational Formation of Protein Complexes

(2011) Caia D. S. Duncan et al.   PLoS Genetics

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Ancillary Subunits Associated With Voltage-Dependent K+ Channels

(2010) Olaf Pongs et al.   PHYSIOLOGICAL REVIEWS

The β Subunit of Voltage-Gated Ca2+ Channels

(2010) Zafir Buraei et al.   PHYSIOLOGICAL REVIEWS

A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation

(2010) Dorothy Beckett et al.   PROTEIN SCIENCE

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Functional Depletion of Mahogunin by Cytosolically Exposed Prion Protein Contributes to Neurodegeneration

(2009) Oishee Chakrabarti et al.   CELL

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE