Guiding tail-anchored membrane proteins to the endoplasmic reticulum in a chaperone cascade

Chaperone-Bound Clients: The Importance of Being Dynamic

(2019) Sebastian Hiller   TRENDS IN BIOCHEMICAL SCIENCES

A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting

(2019) Un Seng Chio et al.   Cell Reports

Structure, Function, and Regulation of the Hsp90 Machinery

(2019) Maximilian M. Biebl et al.   Cold Spring Harbor Perspectives in Biology

Versatility of Preprotein Transfer from the Cytosol to Mitochondria

(2019) Thomas Becker et al.   TRENDS IN CELL BIOLOGY

The Ways of Tails: the GET Pathway and more

(2019) Nica Borgese et al.   PROTEIN JOURNAL

Substrate relay in an Hsp70‐cochaperone cascade safeguards tail‐anchored membrane protein targeting

(2018) Hyunju Cho et al.   EMBO JOURNAL

Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins

(2018) Tobias Jores et al.   JOURNAL OF CELL BIOLOGY

Defining the physiological role of SRP in protein-targeting efficiency and specificity

(2018) Elizabeth A. Costa et al.   SCIENCE

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

Pex19 is involved in importing dually targeted tail-anchored proteins to both mitochondria and peroxisomes

(2018) Bogdan A. Cichocki et al.   TRAFFIC

Structure of the post-translational protein translocation machinery of the ER membrane

(2018) Xudong Wu et al.   NATURE

Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis

(2018) Łukasz Opaliński et al.   Cell Reports

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

(2017) Sarah Haßdenteufel et al.   FEBS LETTERS

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins

(2017) Arati Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A protean clamp guides membrane targeting of tail-anchored proteins

(2017) Un Seng Chio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic basis for a molecular triage reaction

(2017) Sichen Shao et al.   SCIENCE

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

A Spring-Loaded Mechanism Governs the Clamp-like Dynamics of the Skp Chaperone

(2017) Daniel A. Holdbrook et al.   STRUCTURE

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

(2017) Rina Rosenzweig et al.   eLife

Toward a structural understanding of co-translational protein translocation

(2016) Rebecca M Voorhees et al.   CURRENT OPINION IN CELL BIOLOGY

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

Dynamic periplasmic chaperone reservoir facilitates biogenesis of outer membrane proteins

(2016) Shawn M. Costello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATPase and GTPase Tangos Drive Intracellular Protein Transport

(2016) Shu-ou Shan   TRENDS IN BIOCHEMICAL SCIENCES

Multiple selection filters ensure accurate tail-anchored membrane protein targeting

(2016) Meera Rao et al.   eLife

Mechanism of Assembly of a Substrate Transfer Complex during Tail-anchored Protein Targeting

(2015) Harry B. Gristick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the Get3 targeting factor in complex with its membrane protein cargo

(2015) A. Mateja et al.   SCIENCE

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

(2014) Fei Wang et al.   NATURE

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4

(2014) Harry B Gristick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway

(2014) Michael E. Rome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bag6 complex contains a minimal tail-anchor–targeting module and a mock BAG domain

(2014) Jee-Young Mock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

Hydrophobic handoff for direct delivery of peroxisome tail-anchored proteins

(2014) Yinxiao Chen et al.   Nature Communications

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

(2014) Sara Alvira et al.   Nature Communications

Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway

(2013) Yuichi Yagita et al.   JOURNAL OF CELL BIOLOGY

SecYEG activates GTPases to drive the completion of cotranslational protein targeting

(2013) David Akopian et al.   JOURNAL OF CELL BIOLOGY

The Role of Djp1 in Import of the Mitochondrial Protein Mim1 Demonstrates Specificity between a Cochaperone and Its Substrate Protein

(2013) D. Papic et al.   MOLECULAR AND CELLULAR BIOLOGY

Conformation and dynamics of the periplasmic membrane-protein–chaperone complexes OmpX–Skp and tOmpA–Skp

(2013) Björn M Burmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIMIBI twins in protein targeting and localization

(2013) Gert Bange et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins

(2013) Aline C. Simon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Precise timing of ATPase activation drives targeting of tail-anchored proteins

(2013) M. E. Rome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction

(2013) R. Rosenzweig et al.   SCIENCE

The complex process of GETting tail-anchored membrane proteins to the ER

(2012) Justin W Chartron et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex

(2012) Justin W. Chartron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

Get1 Stabilizes an Open Dimer Conformation of Get3 ATPase by Binding Two Distinct Interfaces

(2012) Keiko Kubota et al.   JOURNAL OF MOLECULAR BIOLOGY

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces

(2012) Fabian Seyffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FoldEco: A Model for Proteostasis in E. coli

(2012) Evan T. Powers et al.   Cell Reports

A Structural Model of the Sgt2 Protein and Its Interactions with Chaperones and the Get4/Get5 Complex

(2011) Justin W. Chartron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism of Tail-Anchored Protein Insertion into the ER Membrane

(2011) Fei Wang et al.   MOLECULAR CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

(2011) Moritz Marcinowski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanics of Hsp70 chaperones enables differential interaction with client proteins

(2011) Rainer Schlecht et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

(2011) S. Stefer et al.   SCIENCE

Crystal Structure of Get4-Get5 Complex and Its Interactions with Sgt2, Get3, and Ydj1

(2010) Yi-Wei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asna1/TRC40-mediated membrane insertion of tail-anchored proteins

(2010) V. Favaloro et al.   JOURNAL OF CELL SCIENCE

A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic Reticulum

(2010) Fei Wang et al.   MOLECULAR CELL

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

(2010) Koyeli Mapa et al.   MOLECULAR CELL

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

The structural basis of tail-anchored membrane protein recognition by Get3

(2009) Agnieszka Mateja et al.   NATURE

It takes two to tango: regulation of G proteins by dimerization

(2009) Raphael Gasper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane Insertion

(2009) Junbin Hu et al.   PLoS One

Structural insights into tail-anchored protein binding and membrane insertion by Get3

(2009) Gunes Bozkurt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model for eukaryotic tail-anchored protein binding based on the structure of Get3

(2009) C. J. M. Suloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL