Regulation of proteasome assembly and activity in health and disease

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

(2017) Xiaorong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meddling with Fate: The Proteasomal Deubiquitinating Enzymes

(2017) Stefanie A.H. de Poot et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteasome Structure and Assembly

(2017) Lauren Budenholzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone

(2017) Frances Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mammalian Proteasome Activator PA28 Forms an Asymmetric α 4 β 3 Complex

(2017) Eva M. Huber et al.   STRUCTURE

Phosphatase UBLCP1 controls proteasome assembly

(2017) Shuangwu Sun et al.   Open Biology

Reversible phosphorylation of the 26S proteasome

(2017) Xing Guo et al.   Protein & Cell

Coordinate regulation of autophagy and the ubiquitin proteasome system by MTOR

(2016) Jinghui Zhao et al.   Autophagy

Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases

(2016) Eunju Im et al.   BMB Reports

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

The life cycle of the 26S proteasome: from birth, through regulation and function and onto its death

(2016) Ido Livneh et al.   CELL RESEARCH

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

Emerging role of immunoproteasomes in pathophysiology

(2016) Gagandeep Kaur et al.   IMMUNOLOGY AND CELL BIOLOGY

An evolutionarily conserved pathway controls proteasome homeostasis

(2016) Adrien Rousseau et al.   NATURE

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

(2016) Dawid Walerych et al.   NATURE CELL BIOLOGY

The Proteasome Stress Regulon Is Controlled by a Pair of NAC Transcription Factors in Arabidopsis

(2016) Nicholas P. Gladman et al.   PLANT CELL

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome

(2016) Victoria Cohen-Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

(2016) Y. Shi et al.   SCIENCE

Assembly of an Evolutionarily Conserved Alternative Proteasome Isoform in Human Cells

(2016) Achuth Padmanabhan et al.   Cell Reports

Autophagic Turnover of Inactive 26S Proteasomes in Yeast Is Directed by the Ubiquitin Receptor Cue5 and the Hsp42 Chaperone

(2016) Richard S. Marshall et al.   Cell Reports

Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1

(2016) Nicolas J Lehrbach et al.   eLife

The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction

(2016) Shun Koizumi et al.   eLife

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition

(2016) Corey M Dambacher et al.   eLife

Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases

(2015) Niki Chondrogianni et al.   AGEING RESEARCH REVIEWS

PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression

(2015) Tao Luo et al.   Autophagy

A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly

(2015) Robert J. Tomko et al.   CELL

Identification of minimum Rpn4-responsive elements in genes related to proteasome functions

(2015) Ryohei Shirozu et al.   FEBS LETTERS

The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediate Bortezomib Resistance in Multiple Myeloma

(2015) Bingzong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome Assembly

(2015) Xia Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles

(2015) Kenrick A. Waite et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis

(2015) Richard S. Marshall et al.   MOLECULAR CELL

MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP

(2015) Xin Zhang et al.   MOLECULAR CELL

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97

(2015) K Parzych et al.   Cell Death & Disease

Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1–Pba2 chaperone

(2015) Malte Kock et al.   Nature Communications

The 26S proteasome is a multifaceted target for anti-cancer therapies

(2015) Tatyana A. Grigoreva et al.   Oncotarget

Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly

(2015) Vladyslava Sokolova et al.   Scientific Reports

Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis

(2015) Jun Hamazaki et al.   PLoS Genetics

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

(2015) Diego Acosta-Alvear et al.   eLife

New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells

(2015) Hiroaki Kimura et al.   Journal of Immunology Research

The Rhomboid-Like Superfamily: Molecular Mechanisms and Biological Roles

(2014) Matthew Freeman   Annual Review of Cell and Developmental Biology

Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97

(2014) Zhe Sha et al.   CURRENT BIOLOGY

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Paradigms of protein degradation by the proteasome

(2014) Tomonao Inobe et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Proteasome activation delays aging in vitro and in vivo

(2014) Niki Chondrogianni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of the Testis-specific Proteasome Subunit α4s in Mammals

(2014) Hiroyuki Uechi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular and Cellular Roles of PI31 (PSMF1) Protein in Regulation of Proteasome Function

(2014) Xiaohua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PSMD9 expression predicts radiotherapy response in breast cancer

(2014) Fiona E Langlands et al.   Molecular Cancer

The Intrinsically Disordered Sem1 Protein Functions as a Molecular Tether during Proteasome Lid Biogenesis

(2014) Robert J. Tomko et al.   MOLECULAR CELL

An Inducible Chaperone Adapts Proteasome Assembly to Stress

(2014) Ariane Hanssum et al.   MOLECULAR CELL

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

Quantitative profiling of initiating ribosomes in vivo

(2014) Xiangwei Gao et al.   NATURE METHODS

Regulated protein turnover: snapshots of the proteasome in action

(2014) Sucharita Bhattacharyya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis for Proteasome Formation Controlled by an Assembly Chaperone Nas2

(2014) Tadashi Satoh et al.   STRUCTURE

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Reversible 26S Proteasome Disassembly upon Mitochondrial Stress

(2014) Nurit Livnat-Levanon et al.   Cell Reports

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

Molecular Architecture and Assembly of the Eukaryotic Proteasome

(2013) Robert J. Tomko et al.   Annual Review of Biochemistry

Thymoproteasome: Role in Thymic Selection and Clinical Significance as a Diagnostic Marker for Thymic Epithelial Tumors

(2013) Utano Tomaru et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Emerging role of rhomboid family proteins in mammalian biology and disease

(2013) Nina Bergbold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Assembly of the 20S proteasome

(2013) Mary J. Kunjappu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Proteostasis and neurodegeneration: The roles of proteasomal degradation and autophagy

(2013) Keiji Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Proteasome Regulation by ADP-Ribosylation

(2013) Park F. Cho-Park et al.   CELL

Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis

(2013) Min-Xian Qian et al.   CELL

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Formation of alternative proteasomes: Same lady, different cap?

(2013) Elah Pick et al.   FEBS LETTERS

The Proteasome-associated Protein Ecm29 Inhibits Proteasomal ATPase Activity andin VivoProtein Degradation by the Proteasome

(2013) Alina De La Mota-Peynado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconfiguration of the proteasome during chaperone-mediated assembly

(2013) Soyeon Park et al.   NATURE

Structure of the 26S proteasome with ATP- S bound provides insights into the mechanism of nucleotide-dependent substrate translocation

(2013) P. Sledz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of an Intricate Helical Bundle Dictates the Assembly of the 26S Proteasome Lid

(2013) Eric Estrin et al.   STRUCTURE

The unique functions of tissue-specific proteasomes

(2013) Andrea Kniepert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Involvement of Bag6 and the TRC pathway in proteasome assembly

(2013) Takashi Akahane et al.   Nature Communications

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Structure of a Proteasome Pba1-Pba2 Complex

(2012) Beth M. Stadtmueller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease

(2012) J.-T. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Model of the Human 26S Proteasome

(2012) Paula C.A. da Fonseca et al.   MOLECULAR CELL

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

(2012) Amila Suraweera et al.   MOLECULAR CELL

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

(2012) David Vilchez et al.   NATURE

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

cAMP stimulates the ubiquitin/proteasome pathway in rat spinal cord neurons

(2012) Natura Myeku et al.   NEUROSCIENCE LETTERS

An upstream regulator of the 26S proteasome modulates organ size inArabidopsis thaliana

(2012) Hung M. Nguyen et al.   PLANT JOURNAL

Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assembly

(2012) M.-B. Barrault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting

(2011) Aaron Ciechanover   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t

(2011) Adiratna Mat Ripen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Structural Defects in the Regulatory Particle-Core Particle Interface of the Proteasome Induce a Novel Proteasome Stress Response

(2011) Soyeon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Rpt5 Protein Interactions with the Core Particle and Nas2 Protein Causes the Formation of Faulty Proteasomes That Are Inhibited by Ecm29 Protein

(2011) Stella Yu-Chien Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome Activators

(2011) Beth M. Stadtmueller et al.   MOLECULAR CELL

Incorporation of the Rpn12 Subunit Couples Completion of Proteasome Regulatory Particle Lid Assembly to Lid-Base Joining

(2011) Robert J. Tomko et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity

(2011) X. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissection of the assembly pathway of the proteasome lid in Saccharomyces cerevisiae

(2010) Keisuke Fukunaga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Assembly manual for the proteasome regulatory particle: the first draft

(2010) Soyeon Park et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

(2010) Bogdan I. Florea et al.   CHEMISTRY & BIOLOGY

Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts

(2010) Suzanne Kapeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JBIR-22, An Inhibitor for Protein−Protein Interaction of the Homodimer of Proteasome Assembly Factor 3

(2010) Miho Izumikawa et al.   JOURNAL OF NATURAL PRODUCTS

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

Ecm29 Fulfils Quality Control Functions in Proteasome Assembly

(2010) Andrea Lehmann et al.   MOLECULAR CELL

Heterohexameric Ring Arrangement of the Eukaryotic Proteasomal ATPases: Implications for Proteasome Structure and Assembly

(2010) Robert J. Tomko et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Co- and post-translational modifications of the 26S proteasome in yeast

(2010) Julia Kikuchi et al.   PROTEOMICS

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Assembly, structure, and function of the 26S proteasome

(2010) Lynn Bedford et al.   TRENDS IN CELL BIOLOGY

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome

(2009) Friedrich Förster et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple Proteasome-Interacting Proteins Assist the Assembly of the Yeast 19S Regulatory Particle

(2009) Yasushi Saeki et al.   CELL

Multiple Assembly Chaperones Govern Biogenesis of the Proteasome Regulatory Particle Base

(2009) Minoru Funakoshi et al.   CELL

Assembly Pathway of the Mammalian Proteasome Base Subcomplex Is Mediated by Multiple Specific Chaperones

(2009) Takeumi Kaneko et al.   CELL

The 26 S Proteasome: From Basic Mechanisms to Drug Targeting

(2009) Ami Navon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsm3/S5b Participates in the Assembly Pathway of the 19S Regulatory Particle of the Proteasome

(2009) Benoît Le Tallec et al.   MOLECULAR CELL

Chaperone-mediated pathway of proteasome regulatory particle assembly

(2009) Jeroen Roelofs et al.   NATURE

Hexameric assembly of the proteasomal ATPases is templated through their C termini

(2009) Soyeon Park et al.   NATURE

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis

(2008) Andrew R. Kusmierczyk et al.   BIOLOGICAL CHEMISTRY

Dissecting β-ring assembly pathway of the mammalian 20S proteasome

(2008) Yuko Hirano et al.   EMBO JOURNAL

Hsp90-mediated Assembly of the 26 S Proteasome Is Involved in Major Histocompatibility Complex Class I Antigen Processing

(2008) Taketoshi Yamano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts

(2008) Mitsutoshi Asai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A multimeric assembly factor controls the formation of alternative 20S proteasomes

(2008) Andrew R Kusmierczyk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

(2008) S. Varambally et al.   SCIENCE