Journal
IMMUNOLOGIC RESEARCH
Volume 47, Issue 1-3, Pages 265-272Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-009-8159-9
Keywords
Class I MHC; Lateral diffusion; Membranes; Antigen recognition; Effector T cells
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Funding
- NIH [AI14584]
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Here I summarize decades of work using the biophysics of class I MHC molecules to probe the patchiness and heterogeneity of cell surfaces. This program began as a study of membranes generally. MHC molecules were a convenient probe. However, in recent years, it has become clear that the lateral distribution, clustering, of class I MHC molecules in the membrane affects their recognition by effector CTL. This offers the possibility of enhancing or reducing T-cell recognition of targets by altering the clustering of their membrane proteins.
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