Proximity Interactome Map of the Vac14–Fig4 Complex Using BioID

Insights into Lysosomal PI(3,5)P2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex

(2020) Joshua A. Lees et al.   MOLECULAR CELL

The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation

(2019) Christin Bissig et al.   JOURNAL OF CELL SCIENCE

A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis

(2019) Gaurav Sharma et al.   Autophagy

From hitchhiker to hijacker: pathogen exploitation of endosomal phosphoinositides

(2018) Shirley Qiu et al.   Biochemistry and Cell Biology

Formation of COPI-coated vesicles at a glance

(2018) Eric C. Arakel et al.   JOURNAL OF CELL SCIENCE

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

(2018) Christopher H. Choy et al.   JOURNAL OF CELL SCIENCE

Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry

(2018) Shirley Qiu et al.   VIROLOGY

PIKfyve regulates melanosome biogenesis

(2018) Marc C. Liggins et al.   PLoS Genetics

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy

(2018) Jiu‑Zhou Hou et al.   ONCOLOGY REPORTS

Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles

(2018) Anne-Claude Gingras et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

FIG4 variants in central European patients with amyotrophic lateral sclerosis: a whole-exome and targeted sequencing study

(2017) Alma Osmanovic et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways

(2017) Johan-Owen De Craene et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ProHits-viz: a suite of web tools for visualizing interaction proteomics data

(2017) James D R Knight et al.   NATURE METHODS

PCSF: An R-package for network-based interpretation of high-throughput data

(2017) Murodzhon Akhmedov et al.   PLoS Computational Biology

The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection

(2017) Elizabeth A. Nelson et al.   PLoS Neglected Tropical Diseases

COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

(2017) Peng Xu et al.   eLife

Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency

(2016) Lauren M. Compton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function

(2016) H. Currinn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Meet the neighbors: Mapping local protein interactomes by proximity-dependent labeling with BioID

(2016) Renata Varnaitė et al.   PROTEOMICS

Synergic interaction between amyloid precursor protein and neural cell adhesion molecule promotes neurite outgrowth

(2016) Keping Chen et al.   Oncotarget

Network-Based Interpretation of Diverse High-Throughput Datasets through the Omics Integrator Software Package

(2016) Nurcan Tuncbag et al.   PLoS Computational Biology

InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams

(2015) Henry Heberle et al.   BMC BIOINFORMATICS

FIG4 regulates lysosome membrane homeostasis independent of phosphatase function

(2015) Rajnish Bharadwaj et al.   HUMAN MOLECULAR GENETICS

Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity

(2015) Kachiko Hayashi et al.   INTERNATIONAL IMMUNOLOGY

PIKfyve mediates the motility of late endosomes and lysosomes in neuronal dendrites

(2015) Fuminori Tsuruta et al.   NEUROSCIENCE LETTERS

Reconstruction of the temporal signaling network in Salmonella-infected human cells

(2015) Gungor Budak et al.   Frontiers in Microbiology

The Amyloid Precursor Protein Controls PIKfyve Function

(2015) Zita Balklava et al.   PLoS One

The Vac14-interaction Network Is Linked to Regulators of the Endolysosomal and Autophagic Pathway

(2014) Ulf Schulze et al.   MOLECULAR & CELLULAR PROTEOMICS

Activity-dependent PI(3,5)P2synthesis controls AMPA receptor trafficking during synaptic depression

(2014) Amber J. McCartney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIKfyve Inhibition Interferes with Phagosome and Endosome Maturation in Macrophages

(2014) Grace H.E. Kim et al.   TRAFFIC

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

(2014) Sang H. Min et al.   Nature Communications

Yunis-Varón Syndrome Is Caused by Mutations in FIG4, Encoding a Phosphoinositide Phosphatase

(2013) Philippe M. Campeau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

(2013) Xinming Cai et al.   CHEMISTRY & BIOLOGY

Simultaneous Reconstruction of Multiple Signaling Pathways via the Prize-Collecting Steiner Forest Problem

(2013) Nurcan Tuncbag et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

(2013) Sally Martin et al.   PLoS One

PIKfyve Regulates the Endosomal Localization of CpG Oligodeoxynucleotides to Elicit TLR9-Dependent Cellular Responses

(2013) Kaoru Hazeki et al.   PLoS One

AKT Facilitates EGFR Trafficking and Degradation by Phosphorylating and Activating PIKfyve

(2013) E. E. Er et al.   Science Signaling

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Role of Arf1 in endosomal trafficking of protein–metal complexes and cadmium–metallothionein-1 toxicity in kidney proximal tubule cells

(2011) Natascha A. Wolff et al.   TOXICOLOGY LETTERS

Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J

(2011) Guy M. Lenk et al.   PLoS Genetics

Regulation of PIKfyve phosphorylation by insulin and osmotic stress

(2010) Elaine V. Hill et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

(2010) Markus C Kerr et al.   EMBO JOURNAL

ArPIKfyve Regulates Sac3 Protein Abundance and Turnover

(2010) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Changing phosphoinositides “on the fly”: how trafficking vesicles avoid an identity crisis

(2009) Roberto J. Botelho   BIOESSAYS

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

The COPI system: Molecular mechanisms and function

(2009) R. Beck et al.   FEBS LETTERS

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

(2009) Cole J. Ferguson et al.   HUMAN MOLECULAR GENETICS

PIKfyve-ArPIKfyve-Sac3 Core Complex

(2009) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS

Phosphoinositides and the endocytic pathway

(2008) Michael J. Clague et al.   EXPERIMENTAL CELL RESEARCH

Kinesin Adapter JLP Links PIKfyve to Microtubule-based Endosome-to-Trans-Golgi Network Traffic of Furin

(2008) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PI(3,5)P2 and PI(4,5)P2 Interactomes

(2008) Bruno Catimel et al.   JOURNAL OF PROTEOME RESEARCH

Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase

(2008) Roberto J. Botelho et al.   MOLECULAR BIOLOGY OF THE CELL

High-throughput functional annotation and data mining with the Blast2GO suite

(2008) S. Gotz et al.   NUCLEIC ACIDS RESEARCH