PIKfyve regulates melanosome biogenesis

PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes

(2017) Christin Bissig et al.   TRAFFIC

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

(2016) N. Jin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TPC2 controls pigmentation by regulating melanosome pH and size

(2016) Andrea L. Ambrosio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A melanosomal two-pore sodium channel regulates pigmentation

(2016) Nicholas W. Bellono et al.   Scientific Reports

PI(5)P Regulates Autophagosome Biogenesis

(2015) Mariella Vicinanza et al.   MOLECULAR CELL

Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle

(2015) Elyse K. Paterson et al.   PLoS One

Ion transport in pigmentation

(2014) Nicholas W. Bellono et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

(2014) Assia Shisheva et al.   BIOESSAYS

Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes

(2014) Xiaobing Li et al.   INTERNATIONAL IMMUNOLOGY

The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation

(2014) Y. Lin-Moshier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIKfyve Inhibition Interferes with Phagosome and Endosome Maturation in Macrophages

(2014) Grace H.E. Kim et al.   TRAFFIC

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

(2014) Sang H. Min et al.   Nature Communications

PtdIns5P: News and views of its appearance, disappearance and deeds

(2013) Assia Shisheva   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

(2013) Xinming Cai et al.   CHEMISTRY & BIOLOGY

DrosophilaTRPML Forms PI(3,5)P2-activated Cation Channels in Both Endolysosomes and Plasma Membrane

(2013) Xinghua Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PMEL: a pigment cell-specific model for functional amyloid formation

(2013) Brenda Watt et al.   Pigment Cell & Melanoma Research

Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death

(2013) Sally Martin et al.   PLoS One

Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

(2013) S. Takasuga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage

(2012) H. Ho et al.   CANCER RESEARCH

Organelle Biogenesis: En BLOC Exchange for RAB32 and RAB38

(2012) Michael S. Marks   CURRENT BIOLOGY

A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting

(2012) Zoi Erpapazoglou et al.   MOLECULAR BIOLOGY OF THE CELL

Hermansky-Pudlak syndrome: pigmentary and non-pigmentary defects and their pathogenesis

(2012) Ai-Hua Wei et al.   Pigment Cell & Melanoma Research

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

(2012) S. N. Zolov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

(2011) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J

(2011) Guy M. Lenk et al.   PLoS Genetics

PtdIns(3,5)P2and autophagy in mouse models of neurodegeneration

(2010) Cole J. Ferguson et al.   Autophagy

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

(2010) Markus C Kerr et al.   EMBO JOURNAL

Phosphatidylinositol metabolism and membrane fusion

(2009) Dominic Poccia et al.   BIOCHEMICAL JOURNAL

Physiological factors that regulate skin pigmentation

(2009) Yuji Yamaguchi et al.   BIOFACTORS

Cellular mechanisms regulating human melanogenesis

(2009) H. Y. Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition

(2009) Francesca Giordano et al.   HUMAN MOLECULAR GENETICS

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

(2009) Cole J. Ferguson et al.   HUMAN MOLECULAR GENETICS

PIKfyve-ArPIKfyve-Sac3 Core Complex

(2009) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis

(2009) Cédric Delevoye et al.   JOURNAL OF CELL BIOLOGY

ESCRT-I Function is Required for Tyrp1 Transport from Early Endosomes to the Melanosome Limiting Membrane

(2009) Steven T. Truschel et al.   TRAFFIC

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

PIKfyve: Partners, significance, debates and paradoxes

(2008) A SHISHEVA   CELL BIOLOGY INTERNATIONAL

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse

(2008) Natsuko Jin et al.   EMBO JOURNAL

Melanosomes at a glance

(2008) C. Wasmeier et al.   JOURNAL OF CELL SCIENCE

ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality

(2008) Diego Sbrissa et al.   JOURNAL OF MOLECULAR BIOLOGY

Two newly identified genetic determinants of pigmentation in Europeans

(2008) Patrick Sulem et al.   NATURE GENETICS

Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesis in Human Cells

(2008) Anand K. Ganesan et al.   PLoS Genetics