Targeting tumor vascularization: promising strategies for vascular normalization

Combining microenvironment normalization strategies to improve cancer immunotherapy

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The Epigenetic Profile of Tumor Endothelial Cells. Effects of Combined Therapy with Antiangiogenic and Epigenetic Drugs on Cancer Progression

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Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

(2020) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

In Vivo Tumor Vascular Imaging with Light Emitting Diode-Based Photoacoustic Imaging System

(2020) Marvin Xavierselvan et al.   SENSORS

Impact of Angiogenesis- and Hypoxia-Associated Polymorphisms on Tumor Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection

(2020) Hannah Miller et al.   Cancers

Silencing of VEGFR2 by RGD-Modified Lipid Nanoparticles Enhanced the Efficacy of Anti-PD-1 Antibody by Accelerating Vascular Normalization and Infiltration of T Cells in Tumors

(2020) Riki Cho et al.   Cancers

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Class I histone deacetylase inhibitor suppresses vasculogenic mimicry by enhancing the expression of tumor suppressor and anti-angiogenesis genes in aggressive human TNBC cells

(2019) Aparna Maiti et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

(2019) Racheal G. Akwii et al.   Cells

The bispecific antibody HB-32, blockade of both VEGF and DLL4 shows potent anti-angiogenic activity in vitro and anti-tumor activity in breast cancer xenograft models

(2019) Rihong Zhou et al.   EXPERIMENTAL CELL RESEARCH

Hallmarks of Endothelial Cell Metabolism in Health and Disease

(2019) Xuri Li et al.   Cell Metabolism

Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment

(2019) Xinyu Tian et al.   Journal of Hematology & Oncology

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Acute vs. Chronic vs. Cyclic Hypoxia: Their Differential Dynamics, Molecular Mechanisms, and Effects on Tumor Progression

(2019) Saxena et al.   Biomolecules

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

A gene-based anti-angiogenesis therapy as a novel strategy for cancer treatment

(2019) Asghar Fallah et al.   LIFE SCIENCES

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

(2019) Abhishek S. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

(2018) Andreia Ribeiro et al.   CANCER LETTERS

Anti-angiogenesis effect of Neferine via regulating autophagy and polarization of tumor-associated macrophages in high-grade serous ovarian carcinoma

(2018) Qing Zhang et al.   CANCER LETTERS

Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1α-induced pro-angiogenic factor

(2018) Ji-Chang Wang et al.   CANCER SCIENCE

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

The controversial origin of pericytes during angiogenesis – Implications for cell-based therapeutic angiogenesis and cell-based therapies

(2018) Anna Blocki et al.   CLINICAL HEMORHEOLOGY AND MICROCIRCULATION

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Potential lymphangiogenesis therapies: Learning from current antiangiogenesis therapies-A review

(2018) Michael Yamakawa et al.   MEDICINAL RESEARCH REVIEWS

Near-infrared light-activated IR780-loaded liposomes for anti-tumor angiogenesis and Photothermal therapy

(2018) Xue Yang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa

(2018) Kabir A. Khan et al.   Nature Reviews Clinical Oncology

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

Methods for detecting host genetic modifiers of tumor vascular function using dynamic near-infrared fluorescence imaging

(2018) Jaidip Jagtap et al.   Biomedical Optics Express

Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy

(2018) Yiliang Li et al.   Frontiers in Immunology

MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction

(2018) Teng Ma et al.   Stem Cells International

Apatinib exerts anti-tumor activity to non-Hodgkin lymphoma by inhibition of the Ras pathway

(2018) Yan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Spatially resolved metabolomics to discover tumor-associated metabolic alterations

(2018) Chenglong Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

(2017) Haiying Zhang et al.   Journal of Neuroinflammation

MicroRNA-132 modifies angiogenesis in patients with ischemic cerebrovascular disease by suppressing the NF‑κB and VEGF pathway

(2017) Fengli Che et al.   Molecular Medicine Reports

Intermittent hypoxia and cancer: Undesirable bed partners?

(2017) Isaac Almendros et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

(2017) Martin Teichert et al.   Nature Communications

R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature

(2017) Fangfei Li et al.   Nature Communications

Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism

(2017) Nihed Draoui et al.   Open Biology

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

(2017) Seema Gupta et al.   Frontiers in Oncology

Heterogeneity of tumor endothelial cells and drug delivery

(2016) Kyoko Hida et al.   ADVANCED DRUG DELIVERY REVIEWS

Diverse macrophages polarization in tumor microenvironment

(2016) Inmoo Rhee   ARCHIVES OF PHARMACAL RESEARCH

Abandoning M1/M2 for a Network Model of Macrophage Function

(2016) Matthias Nahrendorf et al.   CIRCULATION RESEARCH

Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo

(2016) Pedro Baptista et al.   International Journal of Nanomedicine

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

(2016) F. Danhier   JOURNAL OF CONTROLLED RELEASE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity

(2016) John D. Martin et al.   Cold Spring Harbor Perspectives in Medicine

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

(2015) R. Hughes et al.   CANCER RESEARCH

Tumor vascular-targeted co-delivery of anti-angiogenesis and chemotherapeutic agents by mesoporous silica nanoparticle-based drug delivery system for synergetic therapy of tumor

(2015) Xiaoyu Li et al.   International Journal of Nanomedicine

Sourcing of an Alternative Pericyte-Like Cell Type from Peripheral Blood in Clinically Relevant Numbers for Therapeutic Angiogenic Applications

(2015) Anna Blocki et al.   MOLECULAR THERAPY

Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor

(2015) Y. Zhao et al.   ONCOLOGIST

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

(2015) Frank Szulzewsky et al.   PLoS One

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

A Heuristic Framework for Image Filtering and Segmentation: Application to Blood Vessel Immunohistochemistry

(2015) Chi-Hsuan Tsou et al.   Analytical Cellular Pathology

Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth

(2015) Carmela Guido et al.   Oncotarget

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Vascular importance of the miR-212/132 cluster

(2014) Regalla Kumarswamy et al.   EUROPEAN HEART JOURNAL

RAS interaction with PI3K p110α is required for tumor-induced angiogenesis

(2014) Miguel Manuel Murillo et al.   JOURNAL OF CLINICAL INVESTIGATION

M1 and M2: there is no “good” and “bad”—How macrophages promote malignancy-associated features in tumorigenesis

(2014) Ole Helm et al.   OncoImmunology

Anti-Angiogenic Drugs: Involvement in Cutaneous Side Effects and Wound-Healing Complication

(2014) Richard J. Bodnar   Advances in Wound Care

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system

(2013) Yu Sakurai et al.   JOURNAL OF CONTROLLED RELEASE

Aflibercept: A Novel VEGF Targeted Agent to Explore the Future Perspectives of Anti-Angiogenic Therapy for the Treatment of Multiple Tumors

(2013) Tina Sharma et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Induction of M2-macrophages by tumour cells and tumour growth promotion by M2-macrophages: A quid pro quo in pancreatic cancer

(2013) L.I. Partecke et al.   PANCREATOLOGY

Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2

(2013) J H Kim et al.   Cell Death & Disease

Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB

(2012) Andrea Banfi et al.   FASEB JOURNAL

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

(2012) Marco Reis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

(2011) A. G. Sorensen et al.   CANCER RESEARCH

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sunitinib Malate for the Treatment of Pancreatic Neuroendocrine Tumors

(2011) Eric Raymond et al.   NEW ENGLAND JOURNAL OF MEDICINE

Scaling rules for diffusive drug delivery in tumor and normal tissues

(2011) James W. Baish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Regulation of the blood–brain barrier integrity by pericytes via matrix metalloproteinases mediated activation of vascular endothelial growth factor in vitro

(2010) Gokulan Thanabalasundaram et al.   BRAIN RESEARCH

Bridges that guide and unite

(2010) Thomas Schmidt et al.   NATURE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

(2010) Sudarshan Anand et al.   NATURE MEDICINE

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

H-Ras Regulates Angiogenesis and Vascular Permeability by Activation of Distinct Downstream Effectors

(2008) Doinita Serban et al.   CIRCULATION RESEARCH

A role for VEGF as a negative regulator of pericyte function and vessel maturation

(2008) Joshua I. Greenberg et al.   NATURE