Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

Sac-1004, a Pseudo-Sugar Derivative of Cholesterol, Restores Erectile Function through Reconstruction of Nonleaky and Functional Cavernous Angiogenesis in the Streptozotocin Induced Diabetic Mouse

(2016) Dulguun Batbold et al.   JOURNAL OF UROLOGY

Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition

(2016) Himakarnika Alluri et al.   PLoS One

Imaging Neuroinflammation in Ischemic Stroke and in the Atherosclerotic Vascular Disease

(2015) Chiara Cerami et al.   Current Vascular Pharmacology

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice

(2015) Vijayendra Agrawal et al.   Oncotarget

Combined effect of vascular-leakage-blocker Sac-1004 and antiangiogenic drug sunitinib on tumor angiogenesis

(2014) Keunho Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blood—Brain Barrier Breakdown Involves Four Distinct Stages of Vascular Damage in Various Models of Experimental Focal Cerebral Ischemia

(2014) Martin Krueger et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Sac-1004, a novel vascular leakage blocker, enhances endothelial barrier through the cAMP/Rac/cortactin pathway

(2013) Sony Maharjan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial barrier antigen-immunoreactivity is conversely associated with blood-brain barrier dysfunction after embolic stroke in rats

(2013) J. Pelz et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

(2013) Felipe Dal-Pizzol et al.   MOLECULAR NEUROBIOLOGY

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Rk1, a Ginsenoside, Is a New Blocker of Vascular Leakage Acting through Actin Structure Remodeling

(2013) Yong-Sun Maeng et al.   PLoS One

Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke

(2013) Bing Chun Yan et al.   PLoS One

Interleukin-1β-induced barrier dysfunction is signaled through PKC-θ in human brain microvascular endothelium

(2012) Robert R. Rigor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The blood-brain barrier in health and disease

(2012) Richard Daneman   ANNALS OF NEUROLOGY

Tight Junction in Blood-Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

(2012) Wei-Ye Liu et al.   CNS Neuroscience & Therapeutics

Blood-Brain Barrier Integrity and Glial Support: Mechanisms that can be Targeted for Novel Therapeutic Approaches in Stroke

(2012) Patrick T. Ronaldson et al.   CURRENT PHARMACEUTICAL DESIGN

Breaking the Barrier in Stroke: What Should we Know? A Mini-Review

(2012) Cesar V. Borlongan et al.   CURRENT PHARMACEUTICAL DESIGN

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: Implications for clinical disease

(2012) Helga E. de Vries et al.   EPILEPSIA

Neuroprotection for Stroke: Current Status and Future Perspectives

(2012) Jens Minnerup et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response After Focal Ischemia in Mice

(2012) Jun Huang et al.   STROKE

Interleukin-1 and Stroke: Biomarker, Harbinger of Damage, and Therapeutic Target

(2011) Adam Denes et al.   CEREBROVASCULAR DISEASES

Heart Disease and Stroke Statistics—2012 Update

(2011) et al.   CIRCULATION

Current therapies in ischemic stroke. Part A. Recent developments in acute stroke treatment and in stroke prevention

(2011) Erasmia Broussalis et al.   DRUG DISCOVERY TODAY

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Decrease in dystrophin expression prior to disruption of brain–blood barrier within the rat piriform cortex following status epilepticus

(2010) Seung Hun Sheen et al.   BRAIN RESEARCH

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

(2010) An-Gaëlle Ceulemans et al.   Journal of Neuroinflammation

Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection

(2010) Joo Eun Jung et al.   MOLECULAR NEUROBIOLOGY

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

Glia-Induced Reversible Disruption of Blood–Brain Barrier Integrity and Neuropathological Response of the Neurovascular Unit

(2010) Colin L. Willis   TOXICOLOGIC PATHOLOGY

CD47 gene knockout protects against transient focal cerebral ischemia in mice

(2009) Guang Jin et al.   EXPERIMENTAL NEUROLOGY

Construction of Mutant TKGFP for Real-Time Imaging of Temporal Dynamics of HIF-1 Signal Transduction Activity Mediated by Hypoxia and Reoxygenation in Tumors in Living Mice

(2009) C.-H. Hsieh et al.   JOURNAL OF NUCLEAR MEDICINE

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

(2009) Shaheen E Lakhan et al.   Journal of Translational Medicine

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tissue Inhibitor of Metalloproteinases Protect Blood—Brain Barrier Disruption in Focal Cerebral Ischemia

(2008) Motoaki Fujimoto et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

(2008) Ssang-Taek Lim et al.   MOLECULAR CELL

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE