Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1α-induced pro-angiogenic factor

Recent Advances in Hypertension and Cardiovascular Toxicities With Vascular Endothelial Growth Factor Inhibition

(2017) Rhian M. Touyz et al.   HYPERTENSION

Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

(2017) Sin-Ting Wang et al.   Cell Death & Disease

HIF-1α acts as a molecular target for simvastatin cytotoxicity in B16.F10 melanoma cells cultured under chemically induced hypoxia

(2017) Emilia Licarete et al.   Oncology Letters

Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials

(2017) Michael Troncone et al.   Oncotarget

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

(2016) Xiaojing Liu et al.   Cell Metabolism

Mitochondrial stress-induced p53 attenuates HIF-1α activity by physical association and enhanced ubiquitination

(2016) A Roy Chowdhury et al.   ONCOGENE

Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells

(2016) Tian-yi Zhou et al.   Scientific Reports

Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a

(2015) Adam R. Wolfe et al.   BREAST CANCER RESEARCH AND TREATMENT

The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator

(2015) Brandon Faubert et al.   CANCER LETTERS

Suppression of tumor angiogenesis by metformin treatment via a mechanism linked to targeting of HER2/HIF-1α/VEGF secretion axis

(2015) Jichang Wang et al.   Oncotarget

Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms

(2014) Anantha Koteswararao Kanugula et al.   FEBS Journal

Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion

(2014) Yanqun Liu et al.   NEUROSCIENCE LETTERS

Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD

(2014) Gerard J. Criner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids

(2013) Hongliang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Anti-angiogenesis therapy in cancer: Current challenges and future perspectives

(2012) Farbod Shojaei   CANCER LETTERS

Statin inhibits hypoxia-induced endothelin-1 via accelerated degradation of HIF-1α in vascular smooth muscle cells

(2012) Tetsuya Hisada et al.   CARDIOVASCULAR RESEARCH

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning

(2012) Michael N. Pollak   Cancer Discovery

Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway

(2011) Ling-Zhi Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

(2010) Assaad A. Eid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atorvastatin inhibits inflammatory angiogenesis in mice through down regulation of VEGF, TNF-α and TGF-β1

(2009) F.A. Araújo et al.   BIOMEDICINE & PHARMACOTHERAPY

Simvastatin Stimulates Vascular Endothelial Growth Factor Production by Hypoxia-inducible Factor-1α Upregulation in Endothelial Cells

(2009) Ai Nishimoto-Hazuku et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model

(2008) Kathryn N. Phoenix et al.   BREAST CANCER RESEARCH AND TREATMENT

Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer

(2008) Akiko Horiuchi et al.   CANCER SCIENCE

Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation

(2008) Xiang-Yang Zhu et al.   LIFE SCIENCES

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL