Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism

FGF-dependent metabolic control of vascular development

(2017) Pengchun Yu et al.   NATURE

Central Role of Metabolism in Endothelial Cell Function and Vascular Disease

(2017) Laura Bierhansl et al.   PHYSIOLOGY

Role of FoxO1 and apoptosis in pulmonary vascular remolding in a rat model of chronic thromboembolic pulmonary hypertension

(2017) Chaosheng Deng et al.   Scientific Reports

Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension

(2017) Robert A. Egnatchik et al.   Pulmonary Circulation

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Cell behaviors and dynamics during angiogenesis

(2016) Charles Betz et al.   DEVELOPMENT

The role of fatty acid β-oxidation in lymphangiogenesis

(2016) Brian W. Wong et al.   NATURE

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

(2016) Q Qu et al.   Cell Death & Disease

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

(2015) N. Jacque et al.   BLOOD

FOXO transcription factors in cancer development and therapy

(2015) Alexandra Coomans de Brachène et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

(2015) Scott Boyd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteomics-Based Metabolic Modeling Reveals That Fatty Acid Oxidation (FAO) Controls Endothelial Cell (EC) Permeability

(2015) Francesca Patella et al.   MOLECULAR & CELLULAR PROTEOMICS

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

FOXO1-Mediated Activation of Akt Plays a Critical Role in Vascular Homeostasis

(2014) Harita Dharaneeswaran et al.   CIRCULATION RESEARCH

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

Metabolism of stromal and immune cells in health and disease

(2014) Bart Ghesquière et al.   NATURE

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

(2013) Mukundh N. Balasubramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Incomplete and transitory decrease of glycolysis

(2013) Sandra Schoors et al.   CELL CYCLE

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Glutaminase regulation in cancer cells: a druggable chain of events

(2013) William P. Katt et al.   DRUG DISCOVERY TODAY

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolutionary origins of the blood vascular system and endothelium

(2013) R. Monahan-Earley et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

(2013) B. F. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

A sulfoximine-based inhibitor of human asparagine synthetase kills l-asparaginase-resistant leukemia cells

(2012) Hideyuki Ikeuchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Endothelial mitochondria—less respiration, more integration

(2012) Lukas N. Groschner et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement

(2011) S. Arima et al.   DEVELOPMENT

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation

(2010) Glenda Parra-Bonilla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells

(2010) Paulina Kucharzewska et al.   EXPERIMENTAL CELL RESEARCH

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase

(2009) Hideyuki Ikeuchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Changes in Human Endothelial Cell Energy Metabolic Capacities during in vitro Cultivation. The Role of “Aerobic Glycolysis” and Proliferation

(2009) Kirsten Peters et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Angiogenesis: A Team Effort Coordinated by Notch

(2009) L.-K. Phng et al.   DEVELOPMENTAL CELL

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS