Insulin Signal Transduction Perturbations in Insulin Resistance

Nur77 Increases Glucose Transport in Mouse Skeletal Muscle Cells by Activating p38MAPK Under Lipotoxicity

(2021) Yan Xu et al.   Journal of Biomaterials and Tissue Engineering

Arsenic disrupts neuronal insulin signaling through increasing free PI3K-p85 and decreasing PI3K activity

(2021) Churaibhon Wisessaowapak et al.   TOXICOLOGY LETTERS

Targeting AKT/PKB to improve treatment outcomes for solid tumors

(2020) M. Iida et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Association between the membrane transporter proteins and type 2 diabetes mellitus

(2020) Sarmistha Saha   Expert Review of Clinical Pharmacology

Ceramides in Metabolism: Key Lipotoxic Players

(2020) Bhagirath Chaurasia et al.   Annual Review of Physiology

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

(2019) Sarah M. Turpin-Nolan et al.   Cell Reports

Molecular Mechanisms Underlying Obesity-Induced Hypothalamic Inflammation and Insulin Resistance: Pivotal Role of Resistin/TLR4 Pathways

(2019) Yacir Benomar et al.   Frontiers in Endocrinology

Resveratrol inhibits the development of obesity-related osteoarthritis via the TLR4 and PI3K/Akt signaling pathways

(2019) Xiaolei Xu et al.   CONNECTIVE TISSUE RESEARCH

AMPK and PPARβ positive feedback loop regulates endurance exercise-mediated GLUT4 expression in skeletal muscle

(2019) Jin-Ho Koh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

β-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity

(2019) Teresa Mezza et al.   DIABETES

Thirty sweet years of GLUT4

(2019) Amira Klip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes

(2019) Ruth C.R. Meex et al.   Obesity Reviews

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

(2019) Burgos-Morón et al.   Journal of Clinical Medicine

FOXO1 inhibition prevents renal ischemia–reperfusion injury via cAMP‐response element binding protein/PPAR‐γ coactivator‐1α‐mediated mitochondrial biogenesis

(2019) Di Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action

(2018) Atefeh Rabiee et al.   CELLULAR SIGNALLING

Modulation of both Insulin Resistance and Cancer Growth by Inositol

(2018) Mariano Bizzarri et al.   CURRENT PHARMACEUTICAL DESIGN

Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions

(2018) Cécile L. Bandet et al.   DIABETES

RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity

(2018) Andisheh Abedini et al.   JOURNAL OF CLINICAL INVESTIGATION

Advanced glycation end products-induced insulin resistance involves repression of skeletal muscle GLUT4 expression

(2018) Danilo C. Pinto-Junior et al.   Scientific Reports

Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

(2018) Yoon S. Oh et al.   Frontiers in Endocrinology

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study

(2018) Ian J. Neeland et al.   DIABETOLOGIA

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Insulin resistance: Review of the underlying molecular mechanisms

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

(2018) Marcus D. Goncalves et al.   NEW ENGLAND JOURNAL OF MEDICINE

RAGE in the pathophysiology of skeletal muscle

(2018) Francesca Riuzzi et al.   Journal of Cachexia Sarcopenia and Muscle

Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes

(2017) Shujuan Huang et al.   International Journal of Biological Sciences

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK as a Therapeutic Target for Treating Metabolic Diseases

(2017) Emily A. Day et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action

(2017) Javier R. Jaldin-Fincati et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanistic interplay between ceramide and insulin resistance

(2017) Federico Reali et al.   Scientific Reports

mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

(2017) Mee-Sup Yoon   Frontiers in Physiology

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

The etiology of oxidative stress in insulin resistance

(2017) Samantha Hurrle et al.   Biomedical Journal

MECHANISMS IN ENDOCRINOLOGY: Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes: a causal mechanism or an innocent bystander?

(2016) Charlotte Brøns et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage

(2016) Barbara Becattini et al.   FASEB JOURNAL

Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis

(2016) Qingzhang Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

(2016) Meric Erikci Ertunc et al.   JOURNAL OF LIPID RESEARCH

Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

(2016) Kalyana C. Nandipati et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction

(2016) Hadi Khodabandehloo et al.   Translational Research

Nuclear Mechanisms of Insulin Resistance

(2016) Sona Kang et al.   TRENDS IN CELL BIOLOGY

Akt/PKB: one kinase, many modifications

(2015) Guillermo Risso et al.   BIOCHEMICAL JOURNAL

MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes

(2015) Andressa Coope et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway

(2015) Chen-Yuan Chiu et al.   JOURNAL OF PATHOLOGY

Molecular aspects of glucose homeostasis in skeletal muscle – A focus on the molecular mechanisms of insulin resistance

(2015) Revathy Carnagarin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Synergistic protective effect of folic acid and vitamin B12against nicotine-induced oxidative stress and apoptosis in pancreatic islets of the rat

(2015) Ankita Bhattacharjee et al.   PHARMACEUTICAL BIOLOGY

Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

(2015) Sean J. Humphrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanisms Linking Inflammation to Insulin Resistance

(2015) Li Chen et al.   International Journal of Endocrinology

Akt: a new activation mechanism

(2014) Yuan Gao et al.   CELL RESEARCH

Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress

(2014) Julio Tobon-Velasco et al.   CNS & Neurological Disorders-Drug Targets

Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini-review

(2014) Nicholas P. Gannon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

(2014) Richard Mackenzie et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Moderate GLUT4 Overexpression Improves Insulin Sensitivity and Fasting Triglyceridemia in High-Fat Diet-Fed Transgenic Mice

(2013) B. J. Atkinson et al.   DIABETES

Cellular and molecular mechanisms of endothelial dysfunction in diabetes

(2013) Anna C Roberts et al.   Diabetes & Vascular Disease Research

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

(2013) Pengda Liu et al.   NATURE CELL BIOLOGY

Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

(2013) P.M. Coen et al.   Obesity

Beta Cell Dysfunction and Insulin Resistance

(2013) Marlon E. Cerf   Frontiers in Endocrinology

Genome-wide meta-analysis of genetic susceptible genes for Type 2 Diabetes

(2012) Paul J Hale et al.   BMC Systems Biology

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue

(2012) X. Julia Xu et al.   JOURNAL OF LIPID RESEARCH

mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8

(2012) Sung Jin Kim et al.   MOLECULAR CELL

The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes

(2011) Jianling Xie et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes: Potential role of AGER1 and SIRT1

(2011) J. Uribarri et al.   DIABETES CARE

Long- and Medium-Chain Fatty Acids Induce Insulin Resistance to a Similar Extent in Humans Despite Marked Differences in Muscle Fat Accumulation

(2011) Joris Hoeks et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

AGE restriction in diabetes mellitus: a paradigm shift

(2011) Helen Vlassara et al.   Nature Reviews Endocrinology

GLUT4 and UBC9 Protein Expression Is Reduced in Muscle from Type 2 Diabetic Patients with Severe Insulin Resistance

(2011) Ulla Kampmann et al.   PLoS One

Toll-Like Receptor Signaling in Liver Diseases

(2011) Gyongyi Szabo et al.   Gastroenterology Research and Practice

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin Signaling: Inositol Phosphates Get into the Akt

(2010) Brendan D. Manning   CELL

Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle

(2010) A. K. Saha et al.   DIABETES

TNFα activation of PKCδ, mediated by NFκB and ER stress, cross-talks with the insulin signaling cascade

(2009) Michael W. Greene et al.   CELLULAR SIGNALLING

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

Inflammation and endoplasmic reticulum stress in obesity and diabetes

(2009) G S Hotamisligil   INTERNATIONAL JOURNAL OF OBESITY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

AMPK as a mediator of hormonal signalling

(2009) Chung Thong Lim et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Advanced Glycation End Products and Insulin Resistance

(2008) Hiroyuki Unoki et al.   CURRENT PHARMACEUTICAL DESIGN

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY