Arsenic disrupts neuronal insulin signaling through increasing free PI3K-p85 and decreasing PI3K activity

Insulin signaling in health and disease

(2021) Alan R. Saltiel   JOURNAL OF CLINICAL INVESTIGATION

Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2

(2021) Churaibhon Wisessaowapak et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Determination of protein phosphorylation by polyacrylamide gel electrophoresis

(2019) Chang-Ro Lee et al.   JOURNAL OF MICROBIOLOGY

The cell biology of systemic insulin function

(2018) Victoria L. Tokarz et al.   JOURNAL OF CELL BIOLOGY

Arsenic impairs insulin signaling in differentiated neuroblastoma SH-SY5Y cells

(2018) Apichaya Niyomchan et al.   NEUROTOXICOLOGY

Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer’s Disease Model

(2018) Sandra Aurora Niño et al.   ACS Chemical Neuroscience

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Biochemical and cellular properties of insulin receptor signalling

(2017) Rebecca A. Haeusler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From the Cover: Arsenic Induces Hippocampal Neuronal Apoptosis and Cognitive Impairments via an Up-Regulated BMP2/Smad-Dependent Reduced BDNF/TrkB Signaling in Rats

(2017) Rukmani Pandey et al.   TOXICOLOGICAL SCIENCES

Sodium Arsenite-Induced Learning and Memory Impairment Is Associated with Endoplasmic Reticulum Stress-Mediated Apoptosis in Rat Hippocampus

(2017) Hongna Sun et al.   Frontiers in Molecular Neuroscience

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells

(2016) Dema Najem et al.   Neuroscience Bulletin

Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway

(2015) Sasidharan Padmaja Divya et al.   TOXICOLOGICAL SCIENCES

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

Acute and long-term effects of arsenite in HepG2 cells: modulation of insulin signaling

(2014) Ingrit Hamann et al.   BIOMETALS

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Arsenic induces diabetic effects through beta-cell dysfunction and increased gluconeogenesis in mice

(2014) Su Liu et al.   Scientific Reports

The Developmental Neurotoxicity of Arsenic: Cognitive and Behavioral Consequences of Early Life Exposure

(2014) Molly Tolins et al.   Annals of Global Health

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

(2014) Enrique Blázquez et al.   Frontiers in Endocrinology

Arsenic Binding to Proteins

(2013) Shengwen Shen et al.   CHEMICAL REVIEWS

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Mechanisms underlying the inhibitory effects of arsenic compounds on protein tyrosine phosphatase (PTP)

(2012) Kanwal Rehman et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

[6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice

(2012) Debrup Chakraborty et al.   TOXICOLOGY LETTERS

Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: Involvement of the adaptive antioxidant response

(2011) Peng Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Arsenic Exposure Hypothesis for Alzheimer Disease

(2010) Gordon Gong et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Health importance of arsenic in drinking water and food

(2010) Semih Ötleş et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Glycogen synthase kinase 3β mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1

(2010) Sanhua Leng et al.   JOURNAL OF ENDOCRINOLOGY