Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance

Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes

(2016) Kei-ichi Ozaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

(2016) Jing Wang et al.   CELLULAR SIGNALLING

Activation of the dsRNA-Activated Protein Kinase PKR in Mitochondrial Dysfunction and Inflammatory Stress in Metabolic Syndrome

(2016) Neetu Sud et al.   CURRENT PHARMACEUTICAL DESIGN

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

(2016) Rachel J. Roth Flach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle

(2016) Hung-Wen Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metabolic Inflammation-Differential Modulation by Dietary Constituents

(2016) Claire Lyons et al.   Nutrients

Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo

(2016) S Pereira et al.   Nutrition & Diabetes

Novel roles for JNK1 in metabolism

(2016) Bengt F. Belgardt et al.   Aging-US

Blocking Nuclear Factor-Kappa B Protects against Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice

(2016) Tianshu Zeng et al.   PLoS One

Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction

(2015) Hesham Soliman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

(2015) Assia Eljaafari et al.   DIABETES

Obesity impairs skeletal muscle regeneration via inhibition of AMP-activated protein kinase

(2015) Xing Fu et al.   DIABETES

ASK1 Inhibitor Halts Progression of Diabetic Nephropathy inNos3-Deficient Mice

(2015) Greg H. Tesch et al.   DIABETES

Peptide-based inhibition of IκB kinase/nuclear factor-κB pathway protects against diabetes-associated nephropathy and atherosclerosis in a mouse model of type 1 diabetes

(2015) Ainhoa Oguiza et al.   DIABETOLOGIA

A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice

(2015) Thereza Cristina Lonzetti Bargut et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Activated PKR inhibits pancreatic β-cell proliferation through sumoylation-dependent stabilization of P53

(2015) Ying Song et al.   MOLECULAR IMMUNOLOGY

TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice

(2015) Hui Cao et al.   Scientific Reports

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

(2014) Tracey McLaughlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells

(2014) Darius Kang Lie Aw et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2)

(2014) Hao Liu et al.   BIOCHEMICAL JOURNAL

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

IKK  Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity

(2014) L. Weissmann et al.   DIABETES

Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice

(2014) Hongfeng Jiang et al.   DIABETOLOGIA

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

(2014) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Role of Extracellular Signal-regulated Kinase 5 in Adipocyte Signaling

(2014) Hong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transformer 2β homolog (Drosophila) (TRA2B) Regulates Protein Kinase C δI (PKCδI) Splice Variant Expression during 3T3L1 Preadipocyte Cell Cycle

(2014) Rekha S. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

(2014) Yanyan Yang et al.   MEDIATORS OF INFLAMMATION

Inhibition of IκB Kinase (IKK) Protects Against Peripheral Nerve Dysfunction of Experimental Diabetes

(2014) Geeta Negi et al.   MOLECULAR NEUROBIOLOGY

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

(2014) Jin Young Huh et al.   MOLECULES AND CELLS

Modulation of obesity-induced inflammation by dietary fats: mechanisms and clinical evidence

(2014) Kim-Tiu Teng et al.   Nutrition Journal

Adipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells

(2014) Yanhong Chen et al.   PLoS One

SRA Regulates Adipogenesis by Modulating p38/JNK Phosphorylation and Stimulating Insulin Receptor Gene Expression and Downstream Signaling

(2014) Shannon Liu et al.   PLoS One

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Deficiency Reduces Insulin Sensitivity in High-Fat Diet-Fed Mice

(2014) Jan Freark de Boer et al.   PLoS One

Regulation of the JNK3 Signaling Pathway during Islet Isolation: JNK3 and c-fos as New Markers of Islet Quality for Transplantation

(2014) Saida Abdelli et al.   PLoS One

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes

(2014) Irbaz I. Badshah et al.   Frontiers in Pharmacology

Role of T Cells in Malnutrition and Obesity

(2014) Valerie A. Gerriets et al.   Frontiers in Immunology

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

(2013) Seung-Hwan Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inflammation, Cytokines and Insulin Resistance: A Clinical Perspective

(2013) Verena Wieser et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases

(2013) H. Patterson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Adipocyte Spliced Form of X-Box-Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis

(2013) H. Sha et al.   DIABETES

Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

(2013) T. Nakamura et al.   DIABETES

Association Between Specific Adipose Tissue CD4+ T-Cell Populations and Insulin Resistance in Obese Individuals

(2013) Elisa Fabbrini et al.   GASTROENTEROLOGY

Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance

(2013) Xin-An Wang et al.   HEPATOLOGY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

(2013) Shannon M Reilly et al.   NATURE MEDICINE

Alteration of JNK-1 Signaling in Skeletal Muscle Fails to Affect Glucose Homeostasis and Obesity-Associated Insulin Resistance in Mice

(2013) Martin Pal et al.   PLoS One

Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKβ

(2013) Tristan J. Iseli et al.   PLoS One

Brd2 Inhibits Adipogenesis via the ERK1/2 Signaling Pathway in 3T3-L1 Adipocytes

(2013) Kun Zang et al.   PLoS One

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance

(2013) S. J. Priceman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice

(2013) Yuan-Yuan Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators

(2013) Li-Fang Yu et al.   ACS Medicinal Chemistry Letters

Mechanisms of Obesity-Induced Inflammation and Insulin Resistance: Insights into the Emerging Role of Nutritional Strategies

(2013) Maeve A. McArdle et al.   Frontiers in Endocrinology

Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBC1D4 phosphorylation

(2012) Jian Liu et al.   ACTA PHARMACOLOGICA SINICA

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice

(2012) M. A. Carvalho-Filho et al.   ENDOCRINOLOGY

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

It takes two to tango: IκBs, the multifunctional partners of NF-κB

(2012) Michael Hinz et al.   IMMUNOLOGICAL REVIEWS

Activation of phosphatidylinositol-3 kinase, AMP-activated kinase and Akt substrate-160 kDa by trans-10, cis-12 conjugated linoleic acid mediates skeletal muscle glucose uptake

(2012) Suresh K. Mohankumar et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C–ι

(2012) Mini P. Sajan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice

(2012) Jinmi Lee et al.   PLoS One

Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes

(2012) Khang Wei Ong et al.   PLoS One

JNK3 Maintains Expression of the Insulin Receptor Substrate 2 (IRS2) in Insulin-Secreting Cells: Functional Consequences for Insulin Signaling

(2012) Saida Abdelli et al.   PLoS One

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

(2012) Noritaka Kawasaki et al.   Scientific Reports

Mechanism of lipid induced insulin resistance: Activated PKCε is a key regulator

(2011) Suman Dasgupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MEK5/ERK5 pathway: The first fifteen years

(2011) Barbara A. Drew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

(2011) Jun Lu et al.   BRAIN BEHAVIOR AND IMMUNITY

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

(2011) Gianluca Svegliati-Baroni et al.   LIVER INTERNATIONAL

p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis

(2011) Jaemin Lee et al.   NATURE MEDICINE

Protein Kinase C Delta (PKCδ) Affects Proliferation of Insulin-Secreting Cells by Promoting Nuclear Extrusion of the Cell Cycle Inhibitor p21Cip1/WAF1

(2011) Felicia Ranta et al.   PLoS One

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes

(2010) Kwang-Hoon Chun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

AMPK inhibition in health and disease

(2010) Benoit Viollet et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo

(2010) J. Cantley et al.   DIABETOLOGIA

Vitamin A Metabolite, All-trans-retinoic Acid, Mediates Alternative Splicing of Protein Kinase C δVIII (PKCδVIII) Isoform via Splicing Factor SC35

(2010) Hercules Apostolatos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of AMPKα1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats

(2010) Eunhui Seo et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

(2010) Guadalupe Sabio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

Mitogen activated protein kinases: a role in inflammatory bowel disease?

(2009) O. J. Broom et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Loss of protein kinase Cβ function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance

(2009) Wei Huang et al.   HEPATOLOGY

Inflammation and endoplasmic reticulum stress in obesity and diabetes

(2009) G S Hotamisligil   INTERNATIONAL JOURNAL OF OBESITY

Kinetic Evidence for Unique Regulation of GLUT4 Trafficking by Insulin and AMP-activated Protein Kinase Activators in L6 Myotubes

(2009) Daniel J. Fazakerley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Disruption of ROCK1 Causes Insulin Resistancein Vivo

(2009) Dae Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK as a mediator of hormonal signalling

(2009) Chung Thong Lim et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Macroscopic Differences in HMGA Oncoproteins Post-Translational Modifications: C-Terminal Phosphorylation of HMGA2 Affects Its DNA Binding Properties

(2009) Riccardo Sgarra et al.   JOURNAL OF PROTEOME RESEARCH

Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate–treated obese mice

(2009) Daniela T. Furuya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Involvement of protein kinase C β–extracellular signal-regulating kinase1/2/p38 mitogen-activated protein kinase–heat shock protein 27 activation in hepatocellular carcinoma cell motility and invasion

(2008) Kun Guo et al.   CANCER SCIENCE

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis

(2008) Jun Eguchi et al.   Cell Metabolism

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

(2008) Zhonglin Xie et al.   CIRCULATION

A769662, a novel activator of AMP-activated protein kinase, inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism

(2008) Daniel Moreno et al.   FEBS LETTERS

Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways

(2008) Keun-Gyu Park et al.   HEPATOLOGY

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

(2008) Tao Pang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE

Epithelial: Lamina Propria Lymphocyte Interactions Promote Epithelial Cell Differentiation

(2007) Stephanie Dahan et al.   GASTROENTEROLOGY