Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of Dietary Fatty Acids in Pancreatic Beta Cell Metabolism, Implications in Homeostasis

(2018) Paloma Acosta-Montaño et al.   Nutrients

The role of polyunsaturated fatty acids (n-3 PUFAs) on the pancreatic β-cells and insulin action

(2018) Habtamu Wondifraw Baynes et al.   Adipocyte

Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges

(2017) Zheng Li et al.   MEDICINAL RESEARCH REVIEWS

PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic β Cells

(2017) Elaine Chen et al.   Scientific Reports

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+Stores

(2016) Alice Marmugi et al.   DIABETES

Neutral Ceramidase Secreted Via Exosome Protects Against Palmitate-Induced Apoptosis in INS-1 Cells

(2016) S. Tang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Calcium release channel RyR2 regulates insulin release and glucose homeostasis

(2015) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

(2015) Cong Tang et al.   NATURE MEDICINE

Targeting endoplasmic reticulum stress in insulin resistance

(2015) Laia Salvadó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

(2015) Wei Hua et al.   PLoS One

Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?

(2014) Rohit B. Sharma et al.   Current Diabetes Reports

Calcium Efflux From the Endoplasmic Reticulum Leads to β-Cell Death

(2014) Takashi Hara et al.   ENDOCRINOLOGY

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

Chaperones Ameliorate Beta Cell Dysfunction Associated with Human Islet Amyloid Polypeptide Overexpression

(2014) Lisa Cadavez et al.   PLoS One

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans

(2013) R. Wagner et al.   DIABETES

FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion

(2013) Hjalti Kristinsson et al.   ENDOCRINOLOGY

Cathepsin B Contributes to Autophagy-related 7 (Atg7)-induced Nod-like Receptor 3 (NLRP3)-dependent Proinflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line

(2013) Shali Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

(2013) Ebru Boslem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus

(2013) M. J. MacDonald et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors

(2012) Ya Tuo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes

(2012) E Leifke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

(2012) Hemant Poudyal et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Mitochondrial dysfunction in pancreatic β cells

(2012) Sachin Supale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ceramide synthase 4 andde novoproduction of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells

(2011) Julien Véret et al.   BIOCHEMICAL JOURNAL

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Fatty Acids Suppress Autophagic Turnover in β-Cells

(2011) Guy Las et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

(2011) Andreas Wiederkehr et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets

(2010) D. M. Faleck et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

(2010) Kyle T. Pfaffenbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

(2010) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

(2010) Deirdre C. Keane et al.   CLINICAL SCIENCE

A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β)

(2010) X. Lei et al.   DIABETES OBESITY & METABOLISM

The role of autophagy in β-cell lipotoxicity and type 2 diabetes

(2010) G. Las et al.   DIABETES OBESITY & METABOLISM

The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity

(2010) Iuliana Ristea Popescu et al.   FEBS LETTERS

The G-Protein−Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid−Induced Secretion of Cholecystokinin

(2010) Alice P. Liou et al.   GASTROENTEROLOGY

Plasma Nonesterified Fatty Acid Intolerance and Hyperglycemia Are Associated with Intravenous Lipid-Induced Impairment of Insulin Sensitivity and Disposition Index

(2010) André C. Carpentier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

New Frontiers in Gut Nutrient Sensor Research: Free Fatty Acid Sensing in the Gastrointestinal Tract

(2010) Satoshi Miyauchi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Review: Free fatty acid receptors: emerging targets for treatment of diabetes and its complications

(2010) R. Lee Kennedy et al.   Therapeutic Advances in Endocrinology and Metabolism

Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation

(2009) Tina Wallin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Linking Fatty Acid Stress to  -Cell Mitochondrial Dynamics

(2009) A. Wiederkehr et al.   DIABETES

Overexpression of GPR40 in Pancreatic  -Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice

(2009) K. Nagasumi et al.   DIABETES

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES

Cellular Production of n-3 PUFAs and Reduction of n-6-to-n-3 Ratios in the Pancreatic  -Cells and Islets Enhance Insulin Secretion and Confer Protection Against Cytokine-Induced Cell Death

(2009) D. Wei et al.   DIABETES

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload

(2009) A. M. Preston et al.   DIABETOLOGIA

Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism

(2009) F. Frigerio et al.   DIABETOLOGIA

Perilipin Is Present in Islets of Langerhans and Protects against Lipotoxicity When Overexpressed in the β-Cell Line INS-1

(2009) Jörgen Borg et al.   ENDOCRINOLOGY

Persistent Oxidative Stress Due to Absence of Uncoupling Protein 2 Associated with Impaired Pancreatic β-Cell Function

(2009) Jingbo Pi et al.   ENDOCRINOLOGY

N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119

(2009) Zhi-Liang Chu et al.   MOLECULAR ENDOCRINOLOGY

A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS)

(2008) Sung-E Choi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Minireview: Lipid Droplets in Lipogenesis and Lipolysis

(2008) Nicole A. Ducharme et al.   ENDOCRINOLOGY

Protective Role of Autophagy in Palmitate-Induced INS-1 β-Cell Death

(2008) Sung-E Choi et al.   ENDOCRINOLOGY

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria: The Hub of Cellular Ca2+ Signaling

(2008) György Szabadkai et al.   PHYSIOLOGY