PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model

PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism

(2018) Loukia Katsouri et al.   JOURNAL OF ALZHEIMERS DISEASE

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

(2015) Avik Roy et al.   Cell Metabolism

Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression

(2015) Thiruchelvam Kariharan et al.   NEUROBIOLOGY OF AGING

Nerve Growth Factor Gene Therapy

(2015) Mark H. Tuszynski et al.   JAMA Neurology

PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease

(2014) Magali Dumont et al.   FASEB JOURNAL

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

(2014) Gustavo A Rodriguez et al.   Journal of Neuroinflammation

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

(2014) Stéphane Palfi et al.   LANCET

Specific Retrograde Transduction of Spinal Motor Neurons Using Lentiviral Vectors Targeted to Presynaptic NMJ Receptors

(2014) I Eleftheriadou et al.   MOLECULAR THERAPY

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice

(2013) A. H. Nagahara et al.   JOURNAL OF NEUROSCIENCE

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Alzheimers Disease: From Pathogenesis to Disease-Modifying Approaches

(2012) Daniela Galimberti et al.   CNS & Neurological Disorders-Drug Targets

Sustained expression of PGC-1  in the rat nigrostriatal system selectively impairs dopaminergic function

(2012) C. Ciron et al.   HUMAN MOLECULAR GENETICS

Peroxisome proliferator-activated receptor-γ cofactors in neurodegeneration

(2012) Loukia Katsouri et al.   IUBMB LIFE

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Nerve growth factor: from the early discoveries to the potential clinical use

(2012) Luigi Aloe et al.   Journal of Translational Medicine

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

(2012) Katherine L Youmans et al.   Molecular Neurodegeneration

Prazosin, an α1-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease

(2012) Loukia Katsouri et al.   NEUROBIOLOGY OF AGING

Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf

(2012) Joanne Clark et al.   PLoS One

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

Object location memory in mice: Pharmacological validation and further evidence of hippocampal CA1 participation

(2009) Fabrício Luiz Assini et al.   BEHAVIOURAL BRAIN RESEARCH

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL