Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors

Recent advances in the understanding of microglial development and homeostasis

(2018) Donovan Low et al.   CELLULAR IMMUNOLOGY

Pharmacogenetics of Angiotensin-Converting Enzyme Inhibitors in Patients with Alzheimer's Disease Dementia

(2018) Fabricio Ferreira de Oliveira et al.   Current Alzheimer Research

Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies

(2018) Keren Asraf et al.   Frontiers in Cellular Neuroscience

Kallikrein–Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation

(2018) Alecia Seliga et al.   Frontiers in Immunology

Effects of Centrally Acting Angiotensin Converting Enzyme Inhibitors on Functional Decline in Patients with Alzheimer's Disease

(2018) Rónán O'Caoimh et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain-Penetrating Angiotensin-Converting Enzyme Inhibitors and Cognitive Change in Patients with Dementia due to Alzheimer's Disease

(2018) Fabricio Ferreira de Oliveira et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial repopulation resolves inflammation and promotes brain recovery after injury

(2017) Rachel A. Rice et al.   GLIA

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

(2017) Maria I. Fonseca et al.   Journal of Neuroinflammation

Microglia-dependent synapse loss in type I interferon-mediated lupus

(2017) Allison R. Bialas et al.   NATURE

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

Involvement of the Bradykinin B1 Receptor in Microglial Activation: In Vitro and In Vivo Studies

(2017) Keren Asraf et al.   Frontiers in Endocrinology

C1q and HMGB1 reciprocally regulate human macrophage polarization

(2016) M. Son et al.   BLOOD

The association of renin-angiotensin system blockade use with the risks of cognitive impairment of aging and Alzheimer’s disease: A meta-analysis

(2016) Shan Zhuang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Angiotensin Converting Enzyme Inhibitors Ameliorate Brain Inflammation Associated with Microglial Activation: Possible Implications for Alzheimer’s Disease

(2016) Nofar Torika et al.   Journal of Neuroimmune Pharmacology

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Elimination of microglia improves cognitive function following cranial irradiation

(2016) Munjal M. Acharya et al.   Scientific Reports

Angiotensin II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpine-induced status epilepticus

(2015) Hong Sun et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

(2015) Eric H. Chang et al.   EBioMedicine

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

Angiotensin-Converting Enzyme Inhibitors and Alzheimer's Disease Progression in Older Adults: Results from the Réseau sur la Maladie d'Alzheimer Français Cohort

(2013) Maria E. Soto et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement

(2013) Allison R Bialas et al.   NATURE NEUROSCIENCE

Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study

(2013) S. Yasar et al.   NEUROLOGY

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

(2013) H. Karatas et al.   SCIENCE

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence

(2012) Fulton T. Crews et al.   BIOLOGICAL PSYCHIATRY

Female mouse fetal loss mediated by maternal autoantibody

(2012) Li Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain

(2012) Polina Feldman et al.   Journal of Neuroinflammation

Association between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis

(2012) Young Ho Lee et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Unknown

(2012) Sangeeta Chavan et al.   MOLECULAR MEDICINE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Potentiation of NMDA Receptor-Dependent Cell Responses by Extracellular High Mobility Group Box 1 Protein

(2012) Marco Pedrazzi et al.   PLoS One

Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease

(2011) Yi-Fei Dong et al.   FASEB JOURNAL

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Angiotensin-converting enzyme (ACE) serum levels and gene polymorphism in Egyptian patients with systemic lupus erythematosus

(2011) D Abbas et al.   LUPUS

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms

(2010) T. W. Faust et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced synaptic connectivity and epilepsy in C1q knockout mice

(2010) Yunxiang Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications

(2010) Juan M. Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

Angiotensin Converting Enzyme Inhibitors and Cognitive and Functional Decline in Patients with Alzheimer's Disease: An Observational Study

(2008) Ihab M. Hajjar et al.   American Journal of Alzheimers Disease and Other Dementias

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus

(2008) Yoshiyuki Arinuma et al.   ARTHRITIS AND RHEUMATISM

Unknown

(2008) John Klune et al.   MOLECULAR MEDICINE

Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS

(2008) J. Rodriguez-Pallares et al.   NEUROBIOLOGY OF DISEASE

Induction and subcellular localization of high-mobility group box–1 (HMGB1) in the postischemic rat brain

(2007) Jung-Bin Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH