The Coming of Age of the Angiotensin Hypothesis in Alzheimer’s Disease: Progress Toward Disease Prevention and Treatment?

Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease

(2018) Sultan Chaudhury et al.   NEUROBIOLOGY OF AGING

Associations of Anti-Hypertensive Treatments with Alzheimer's Disease, Vascular Dementia, and Other Dementias

(2018) Neil M. Davies et al.   JOURNAL OF ALZHEIMERS DISEASE

Angiotensin-Converting Enzyme and Progression of White Matter Lesions and Brain Atrophy – The SMART-MR Study

(2018) Hadassa M. Jochemsen et al.   JOURNAL OF ALZHEIMERS DISEASE

The Renin-Angiotensin System and Antihypertensive Drugs in Alzheimer's Disease: Current Standing of the Angiotensin Hypothesis?

(2018) Patrick G. Kehoe et al.   JOURNAL OF ALZHEIMERS DISEASE

Associations of Angiotensin Targeting Antihypertensive Drugs with Mortality and Hospitalization in Primary Care Patients with Dementia

(2018) Patrick Gavin Kehoe et al.   JOURNAL OF ALZHEIMERS DISEASE

Renin Angiotensin Aldosterone System Inhibition in Controlling Dementia-Related Cognitive Decline

(2018) Rónán O'Caoimh et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of Centrally Acting Angiotensin Converting Enzyme Inhibitors on Functional Decline in Patients with Alzheimer's Disease

(2018) Rónán O'Caoimh et al.   JOURNAL OF ALZHEIMERS DISEASE

Angiotensin-III is Increased in Alzheimer’s Disease in Association with Amyloid-β and Tau Pathology

(2017) Patrick Gavin Kehoe et al.   JOURNAL OF ALZHEIMERS DISEASE

Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer’s (HEART) Trial

(2017) Whitney Wharton et al.   JOURNAL OF ALZHEIMERS DISEASE

The Rationale and Design of the Reducing Pathology in Alzheimer’s Disease through Angiotensin TaRgeting (RADAR) Trial

(2017) Patrick G. Kehoe et al.   JOURNAL OF ALZHEIMERS DISEASE

Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases

(2017) Janou A. Y. Roubroeks et al.   JOURNAL OF NEUROCHEMISTRY

Polygenic score prediction captures nearly all common genetic risk for Alzheimer's disease

(2017) Valentina Escott-Price et al.   NEUROBIOLOGY OF AGING

Memory is preserved in older adults taking AT1 receptor blockers

(2017) Jean K. Ho et al.   Alzheimers Research & Therapy

Type 2 Diabetes, Related Conditions, in Relation and Dementia: An Opportunity for Prevention?

(2017) José A. Luchsinger   JOURNAL OF ALZHEIMERS DISEASE

Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence

(2016) A. Y. Fouda et al.   CLINICAL SCIENCE

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Dementia in western Europe: epidemiological evidence and implications for policy making

(2016) Yu-Tzu Wu et al.   LANCET NEUROLOGY

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

(2016) Patrick Gavin Kehoe et al.   Alzheimers Research & Therapy

Diabetes mellitus as a compelling indication for use of renin angiotensin system blockers: systematic review and meta-analysis of randomized trials

(2016) Sripal Bangalore et al.   BMJ-British Medical Journal

Diabetes mellitus as a compelling indication for use of renin angiotensin system blockers: systematic review and meta-analysis of randomized trials

(2016) Sripal Bangalore et al.   BMJ-British Medical Journal

Cerebrovascular disease in ageing and Alzheimer’s disease

(2015) Seth Love et al.   ACTA NEUROPATHOLOGICA

The Intrarenal Renin-Angiotensin System in Hypertension

(2015) Robert M. Carey   ADVANCES IN CHRONIC KIDNEY DISEASE

Modulation of Renin-Angiotensin System May Slow Conversion from Mild Cognitive Impairment to Alzheimer's Disease

(2015) Whitney Wharton et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

A Systems Approach to Drug Discovery in Alzheimer’s Disease

(2015) Michael Shelanski et al.   Neurotherapeutics

Association Between Angiotensin Receptor Blockers and Longitudinal Decline in Tau in Mild Cognitive Impairment

(2015) Ihab Hajjar et al.   JAMA Neurology

Pharmacokinetic evaluation of lisinopril-tryptophan, a novel C-domain ACE inhibitor

(2014) Paolo Denti et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism

(2014) Kristoffer Brännström et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease

(2014) Hadassa M Jochemsen et al.   Alzheimers Research & Therapy

ACE for all – a molecular perspective

(2014) Charlotte Harrison et al.   Journal of Cell Communication and Signaling

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

Aβ43 Is the Earliest-Depositing Aβ Species in APP Transgenic Mouse Brain and Is Converted to Aβ41 by Two Active Domains of ACE

(2013) Kun Zou et al.   AMERICAN JOURNAL OF PATHOLOGY

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

(2013) Ross G. Douglas et al.   CLINICAL SCIENCE

Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

(2013) Emma Louise Ashby et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Antihypertensive Therapy and Cerebral Hemodynamics in Executive Mild Cognitive Impairment: Results of a Pilot Randomized Clinical Trial

(2013) Ihab Hajjar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

C domain-selective inhibition of angiotensin-converting enzyme

(2013) Mario R Ehlers et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study

(2013) S. Yasar et al.   NEUROLOGY

N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

(2013) Gregory Antonios et al.   Acta Neuropathologica Communications

Impact of Angiotensin Receptor Blockers on Alzheimer Disease Neuropathology in a Large Brain Autopsy Series

(2012) Ihab Hajjar et al.   ARCHIVES OF NEUROLOGY

Six Commercially Available Angiotensin II AT1 Receptor Antibodies are Non-specific

(2012) Julius Benicky et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type 1 Receptor Protein

(2012) Marcela Herrera et al.   HYPERTENSION

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging

(2011) Vincenzo Solfrizzi et al.   AGE

Rosiglitazone and Pioglitazone for the Treatment of Alzheimer's Disease

(2011) Benjamin W Miller et al.   ANNALS OF PHARMACOTHERAPY

Antihypertensive Therapy Is Associated with Reduced Rate of Conversion to Alzheimer's Disease in Midregional Proatrial Natriuretic Peptide Stratified Subjects with Mild Cognitive Impairment

(2011) Philine Schneider et al.   BIOLOGICAL PSYCHIATRY

Diagnosed hypertension in Canada: incidence, prevalence and associated mortality

(2011) C. Robitaille et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

Angiotensin II Binding to Angiotensin I–Converting Enzyme Triggers Calcium Signaling

(2011) Paola B. Guimarães et al.   HYPERTENSION

Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease

(2011) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats

(2011) Donglin Zhu et al.   PLoS One

Brain renin-angiotensin—A new look at an old system

(2011) John W. Wright et al.   PROGRESS IN NEUROBIOLOGY

Angiotensin-Converting Enzyme as a Potential Target for Treatment of Alzheimer's Disease: Inhibition or Activation?

(2011) Kun Zou et al.   REVIEWS IN THE NEUROSCIENCES

Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease

(2010) Koji Yamada et al.   BRAIN RESEARCH

Strain differences in the effects of Angiotensin IV on mouse cognition

(2010) Bruno J.D. Golding et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Placebo-Controlled Trials of Blood Pressure–Lowering Therapies for Primary Prevention of Dementia

(2010) Jan A. Staessen et al.   HYPERTENSION

The N Domain of Human Angiotensin-I-converting Enzyme

(2010) Colin S. Anthony et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Signalling and Alzheimer’s Disease

(2010) Michael J. Berridge   NEUROCHEMICAL RESEARCH

The Vascular Hypothesis of Alzheimer’s Disease: Bench to Bedside and Beyond

(2010) Jack C. de la Torre   Neurodegenerative Diseases

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

The neuropathology of probable Alzheimer disease and mild cognitive impairment

(2009) Julie A. Schneider et al.   ANNALS OF NEUROLOGY

Angiotensin-Converting Enzyme Inhibitors and Cognitive Decline in Older Adults With Hypertension

(2009) Kaycee M. Sink et al.   ARCHIVES OF INTERNAL MEDICINE

Antagonist of peroxisome proliferator-activated receptor γ induces cerebellar amyloid-β levels and motor dysfunction in APP/PS1 transgenic mice

(2009) Jing Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors

(2009) Albert Fournier et al.   Expert Review of Neurotherapeutics

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Aβ42-to-Aβ40- and Angiotensin-converting Activities in Different Domains of Angiotensin-converting Enzyme

(2009) Kun Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different contributions of the angiotensin-converting enzyme C-domain and N-domain in subjects with the angiotensin-converting enzyme II and DD genotype

(2009) Joep HM van Esch et al.   JOURNAL OF HYPERTENSION

IRAP and AT1receptor mediated effects of angiotensin IV

(2009) A. G. Dupont et al.   JOURNAL OF INTERNAL MEDICINE

Duration of antihypertensive drug use and risk of dementia: A prospective cohort study

(2009) M.D.M. Haag et al.   NEUROLOGY

Angiotensins in Alzheimer's disease – friend or foe?

(2009) Patrick G. Kehoe et al.   TRENDS IN NEUROSCIENCES

Pathophysiology of vascular dementia

(2009) Francesco Iemolo et al.   Immunity & Ageing

O1-05-05: Use of angiotensin receptor blockers is associated with a lower incidence and progression of Alzheimer's disease

(2008) Benjamin Wolozin et al.   Alzheimers & Dementia

Angiotensin Converting Enzyme Inhibitors and Cognitive and Functional Decline in Patients with Alzheimer's Disease: An Observational Study

(2008) Ihab M. Hajjar et al.   American Journal of Alzheimers Disease and Other Dementias

Effects of Cardiovascular Medications on Rate of Functional Decline in Alzheimer Disease

(2008) P.B. Rosenberg et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Antihypertensive Medications Influence the Rate of Conversion From Mild Cognitive Impairment to Alzheimer Disease

(2008) Luca Rozzini   ARCHIVES OF NEUROLOGY

Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study

(2008) Joseph H. Lee   ARCHIVES OF NEUROLOGY

Candesartan improves memory decline in mice: Involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin

(2008) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Telmisartan prevented cognitive decline partly due to PPAR-γ activation

(2008) Masaki Mogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

(2008) Siew Chai et al.   BMC NEUROSCIENCE

Cognitive-enhancing effects of angiotensin IV

(2008) Paul R Gard   BMC NEUROSCIENCE

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY

Isomerization of the Asp7 Residue Results in Zinc‐Induced Oligomerization of Alzheimer’s Disease Amyloid β(1–16) Peptide

(2008) Philipp O. Tsvetkov et al.   CHEMBIOCHEM

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-β peptides

(2008) Xiaoou Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

(2008) Anthony L. Albiston et al.   FASEB JOURNAL

Epidemiology of stroke and high blood pressure in Africa

(2008) G A Mensah   HEART

Continuous Activation of Renin-Angiotensin System Impairs Cognitive Function in Renin/Angiotensinogen Transgenic Mice

(2008) Shinji Inaba et al.   HYPERTENSION

Renin-angiotensin system revisited

(2008) F. Fyhrquist et al.   JOURNAL OF INTERNAL MEDICINE

Brain renin angiotensin in disease

(2008) M. Ian Phillips et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial

(2008) Ruth Peters et al.   LANCET NEUROLOGY

Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease

(2008) M PAKASKI et al.   NEUROCHEMISTRY INTERNATIONAL

Alzheimer’s disease risk variants show association with cerebrospinal fluid amyloid beta

(2008) John S. K. Kauwe et al.   NEUROGENETICS

Assessment of Alzheimer’s disease case–control associations using family-based methods

(2008) Brit-Maren M. Schjeide et al.   NEUROGENETICS

Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats

(2008) D. Kumaran et al.   NEUROSCIENCE

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Candidate Single-Nucleotide Polymorphisms From a Genomewide Association Study of Alzheimer Disease

(2007) Hao Li et al.   ARCHIVES OF NEUROLOGY

Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis

(2007) Tricia A. Thornton-Wells et al.   GENETIC EPIDEMIOLOGY

Angiotensin-Converting Enzyme C-Terminal Catalytic Domain Is the Main Site of Angiotensin I Cleavage In Vivo

(2007) Sebastien Fuchs et al.   HYPERTENSION

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

(2007) J. S. Miners et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY