Losartan improves cerebrovascular function in a mouse model of Alzheimer's disease with combined overproduction of amyloid-β and transforming growth factor-β1

Cerebral Circulation

(2015) Edith Hamel   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Simvastatin Restored Vascular Reactivity, Endothelial Function and Reduced String Vessel Pathology in a Mouse Model of Cerebrovascular Disease

(2015) Xin-Kang Tong et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

(2014) Brice Ongali et al.   NEUROBIOLOGY OF DISEASE

Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease

(2013) Luqing Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice

(2013) Panayiota Papadopoulos et al.   NEUROBIOLOGY OF AGING

Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains

(2012) Minjie Tian et al.   FEBS LETTERS

Midlife Blood Pressure, Plasma β-Amyloid, and the Risk for Alzheimer Disease

(2012) Nilay S. Shah et al.   HYPERTENSION

Age-Dependent Rescue by Simvastatin of Alzheimer's Disease Cerebrovascular and Memory Deficits

(2012) X.-K. Tong et al.   JOURNAL OF NEUROSCIENCE

Neurovascular function in Alzheimer's disease patients and experimental models

(2011) Nektaria Nicolakakis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model

(2011) Kumiko Taguchi et al.   PHARMACOLOGICAL RESEARCH

Transgenic Mice Overexpressing APP and Transforming Growth Factor-β1 Feature Cognitive and Vascular Hallmarks of Alzheimer's Disease

(2010) Brice Ongali et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective in vivo antagonism of endothelin receptors in transforming growth factor-β1 transgenic mice that mimic the vascular pathology of Alzheimer’s diseaseThis article is one of a selection of papers published in the two-part special issue entitled 20 Years of Endothelin Research.

(2010) Panayiota Papadopoulos et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Losartan Normalizes Endothelium-Derived Hyperpolarizing Factor–Mediated Relaxation by Activating Ca2+-Activated K+ Channels in Mesenteric Artery From Type 2 Diabetic GK Rat

(2010) Takayuki Matsumoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neurodegeneration and the neurovascular unit

(2010) Berislav V Zlokovic   NATURE MEDICINE

Review: Molecular genetics and pathology of hereditary small vessel diseases of the brain

(2010) Y. Yamamoto et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partially Due to Peroxisome Proliferator-Activated Receptor-γ Activation in Mice With Chronic Cerebral Hypoperfusion

(2010) Kazuo Washida et al.   STROKE

The contribution of astrocyte signalling to neurovascular coupling

(2009) Giorgio Carmignoto et al.   BRAIN RESEARCH REVIEWS

Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling

(2009) Kuo-Hui Su et al.   CARDIOVASCULAR RESEARCH

The brain RAS and Alzheimer's disease

(2009) John W. Wright et al.   EXPERIMENTAL NEUROLOGY

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

(2009) Kana Tsukuda et al.   HYPERTENSION

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

(2009) Xin-Kang Tong et al.   NEUROBIOLOGY OF DISEASE

Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory

(2009) Anthony L. Albiston et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Telmisartan prevented cognitive decline partly due to PPAR-γ activation

(2008) Masaki Mogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cognitive-enhancing effects of angiotensin IV

(2008) Paul R Gard   BMC NEUROSCIENCE

Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice

(2008) Björn Maul et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway

(2008) Filippo Caraci et al.   NEUROBIOLOGY OF DISEASE

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats

(2007) Q Dai et al.   BRITISH JOURNAL OF PHARMACOLOGY

Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice

(2006) Amy R. deIpolyi et al.   NEUROBIOLOGY OF AGING