The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression

Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development

(2020) Yuhei Yamauchi et al.   GENES TO CELLS

FBXO25 promotes cutaneous squamous cell carcinoma growth and metastasis via cyclin D1

(2020) Aleksandar Kuzmanov et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis

(2020) Morgan S. Schrock et al.   SEMINARS IN CANCER BIOLOGY

The COP9 Signalosome: A Multi-DUB Complex

(2020) Wolfgang Dubiel et al.   Biomolecules

Functional Versatility of the CDK Inhibitor p57Kip2

(2020) Justine Creff et al.   Frontiers in Cell and Developmental Biology

FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

(2019) Long Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

SPSB1 enhances ovarian cancer cell survival by destabilizing p21

(2019) Hyun-Jung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functions of cyclins and CDKs in mammalian gametogenesis†

(2019) Jessica Y Chotiner et al.   BIOLOGY OF REPRODUCTION

TRIM69 inhibits cataractogenesis by negatively regulating p53

(2019) Xianfang Rong et al.   Redox Biology

Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells

(2019) Bin Hu et al.   Cells

Abrogation of FBW7α-dependent p53 degradation enhances p53’s function as a tumor suppressor

(2019) Vivek Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C

(2019) Pablo Lara-Gonzalez et al.   DEVELOPMENTAL CELL

Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E

(2019) Brittney Davidge et al.   JOURNAL OF CELL SCIENCE

CyclinB1 deubiquitination by USP14 regulates cell cycle progression in breast cancer

(2019) Bing Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21

(2019) Sen Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

UHRF2 promotes DNA damage response by decreasing p21 via RING finger domain

(2018) Yangyang Wang et al.   BIOTECHNOLOGY LETTERS

Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2

(2018) Meidan Ying et al.   BLOOD

Structural biology of the separase–securin complex with crucial roles in chromosome segregation

(2018) Shukun Luo et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cezanne/OTUD7B is a cell cycle‐regulated deubiquitinase that antagonizes the degradation of APC/C substrates

(2018) Thomas Bonacci et al.   EMBO JOURNAL

Regulation of the Mdm2–p53 pathway by the ubiquitin E3 ligase MARCH7

(2018) Kailiang Zhao et al.   EMBO REPORTS

USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis

(2018) Ling Dong et al.   ONCOGENE

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses

(2018) Tanggang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases

(2018) Emil Bulatov et al.   IMMUNOLOGY LETTERS

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

(2018) Victoria J. Gennaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological Aggressiveness of Subclinical No-Mass Ductal Carcinoma In Situ (DCIS) Can Be Reflected by the Expression Profiles of Epithelial-Mesenchymal Transition Triggers

(2018) Bartlomiej Szynglarewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ubiquitin signaling and autophagy

(2017) Paolo Grumati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance

(2017) Kuntal Biswas et al.   MOLECULAR CANCER RESEARCH

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A

(2017) Shanming Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

(2017) Tongzheng Liu et al.   Nature Communications

Cell cycle regulation and anticancer drug discovery

(2017) Bai Jingwen et al.   Cancer Biology & Medicine

CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells

(2017) Zhi Chen et al.   Scientific Reports

NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

(2016) Xiaofeng Liu et al.   EMBO REPORTS

TP53Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

(2016) Liacine Bouaoun et al.   HUMAN MUTATION

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

(2016) Mindy I. Davis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites

(2016) Byung-Hoon Lee et al.   NATURE

Cyclin-dependent kinase 1-dependent activation of APC/C ubiquitin ligase

(2016) K. Fujimitsu et al.   SCIENCE

Targeting WEE1 Kinase in Cancer

(2016) Christopher J. Matheson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53

(2016) Hongmei Liu et al.   PLOS BIOLOGY

WP1130 increases doxorubicin sensitivity in hepatocellular carcinoma cells through usp9x-dependent p53 degradation

(2015) Hao Liu et al.   CANCER LETTERS

Regulating the stability and localization of CDK inhibitor p27Kip1via CSN6-COP1 axis

(2015) Hyun Ho Choi et al.   CELL CYCLE

COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth

(2015) Hyun Ho Choi et al.   Oncotarget

The Deubiquitinating Enzyme USP24 Is a Regulator of the UV Damage Response

(2015) Ling Zhang et al.   Cell Reports

Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1

(2015) Zhenghong Lin et al.   Cell Discovery

Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages

(2014) Lihuan Cao et al.   BMC EVOLUTIONARY BIOLOGY

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

(2014) X. Zheng et al.   GENES & DEVELOPMENT

USP11 regulates p53 stability by deubiquitinating p53

(2014) Jia-ying Ke et al.   Journal of Zhejiang University-SCIENCE B

E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation

(2014) Anand Thirunavukarasou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

(2014) Qiang Zou et al.   NATURE IMMUNOLOGY

Ubiquitin Ligases and Cell Cycle Control

(2013) Leonardo K. Teixeira et al.   Annual Review of Biochemistry

Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression

(2013) Yang Xu et al.   CELL CYCLE

ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21WAF1

(2013) J Han et al.   CELL DEATH AND DIFFERENTIATION

Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals

(2013) E. T. Ables et al.   DEVELOPMENT

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling

(2013) Xing Huang et al.   EMBO JOURNAL

Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation Independently of Its Hydrolase Activity

(2013) Tomohiro Kabuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner

(2013) Akihiro Yoshida et al.   Scientific Reports

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation

(2012) X. Zhi et al.   CANCER RESEARCH

Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes

(2012) Olga A. Issaenko et al.   CELL CYCLE

CDK inhibitor p57Kip2is negatively regulated by COP9 signalosome subunit 6

(2012) Bo Chen et al.   CELL CYCLE

The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer

(2012) Jayoung Kim et al.   CELL CYCLE

The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation

(2012) C M Das et al.   ONCOGENE

Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer

(2012) LIXIN WANG et al.   ONCOLOGY REPORTS

Ubiquitylation of p53 by the APC/C inhibitor Trim39

(2012) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein degradation in DNA damage response

(2012) Ilektra Kouranti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence

(2011) Yahui Kong et al.   AGING CELL

Targeting the degradation of cyclin D1 will help to eliminate oncogene addiction

(2011) James T. Lee et al.   CELL CYCLE

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

(2011) Xiao-Xin Sun et al.   EMBO JOURNAL

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

(2011) Andreas K Hock et al.   EMBO JOURNAL

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress

(2011) Juhong Liu et al.   EMBO JOURNAL

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2

(2011) Hae Mi Joo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers

(2011) Ruiying Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitin Homeostasis Is Critical for Synaptic Development and Function

(2011) P.-C. Chen et al.   JOURNAL OF NEUROSCIENCE

Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry

(2011) XiaoDong Huang et al.   MOLECULAR CELL

COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ

(2011) H H Choi et al.   ONCOGENE

Evidence for OTUD-6B Participation in B Lymphocytes Cell Cycle after Cytokine Stimulation

(2011) Zhongping Xu et al.   PLoS One

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

(2010) Hiroyuki Inuzuka et al.   CANCER CELL

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

CRL2LRR-1 Targets a CDK Inhibitor for Cell Cycle Control in C. elegans and Actin-Based Motility Regulation in Human Cells

(2010) Natalia G. Starostina et al.   DEVELOPMENTAL CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Regulation of the endothelial cell cycle by the ubiquitin-proteasome system

(2009) P. Fasanaro et al.   CARDIOVASCULAR RESEARCH

Effete-mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila

(2009) D. Chen et al.   DEVELOPMENT

Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis

(2009) Eun-Woo Lee et al.   EMBO JOURNAL

Suppression of Cancer Cell Growth by Promoting Cyclin D1 Degradation

(2009) Jing Shan et al.   MOLECULAR CELL

Trim24 targets endogenous p53 for degradation

(2009) Kendra Allton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of APC/C Activators in Mitosis and Meiosis

(2008) Jillian A. Pesin et al.   Annual Review of Cell and Developmental Biology

A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation

(2008) Minsoo Kim et al.   EMBO REPORTS

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing

(2008) Y. Kim et al.   GENES & DEVELOPMENT

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2Pathway during S Phase and after UV Irradiation

(2008) Hideo Nishitani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities

(2008) Benjamin Nicholson et al.   PROTEIN SCIENCE