The Machado–Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53

Toward therapeutic targets for SCA3: Insight into the role of Machado–Joseph disease protein ataxin-3 in misfolded proteins clearance

(2015) Xiaoling Li et al.   PROGRESS IN NEUROBIOLOGY

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)

(2015) Fei Ge et al.   Oncotarget

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

(2015) Rui Gao et al.   PLoS Genetics

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death

(2014) L. Pei et al.   JOURNAL OF NEUROSCIENCE

p53 regulates a non-apoptotic death induced by ROS

(2013) J Montero et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-92a Upholds Bmp Signaling by Targeting noggin3 during Pharyngeal Cartilage Formation

(2013) Guozhu Ning et al.   DEVELOPMENTAL CELL

Knockdown of Cyclin-dependent Kinase 10 (cdk10) Gene Impairs Neural Progenitor Survival via Modulation ofraf1aGene Expression

(2013) Chi-Wei Yeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurogenesis in zebrafish – from embryo to adult

(2013) Rebecca Schmidt et al.   Neural Development

Inverse occurrence of cancer and Alzheimer disease: A population-based incidence study

(2013) M. Musicco et al.   NEUROLOGY

p53 in neurodegenerative diseases and brain cancers

(2013) Frédéric Checler et al.   PHARMACOLOGY & THERAPEUTICS

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

p53 at the crossroads between cancer and neurodegeneration

(2012) Cristina Lanni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multitasking p53 promotes necrosis

(2012) Kim Baumann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3

(2012) Mário N. Laço et al.   PLoS One

CAG expansion induces nucleolar stress in polyglutamine diseases

(2012) H. Tsoi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

(2011) Xiao-Xin Sun et al.   EMBO JOURNAL

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

(2011) Andreas K Hock et al.   EMBO JOURNAL

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress

(2011) Juhong Liu et al.   EMBO JOURNAL

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

(2011) Xinna Zhang et al.   EMBO JOURNAL

Global Identification of SMAD2 Target Genes Reveals a Role for Multiple Co-regulatory Factors in Zebrafish Early Gastrulas

(2011) Zhaoting Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP

(2011) K. Matthew Scaglione et al.   MOLECULAR CELL

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

(2011) Kirsten Kuhlbrodt et al.   NATURE CELL BIOLOGY

Role of Inositol 1,4,5-Trishosphate Receptors in Pathogenesis of Huntington’s Disease and Spinocerebellar Ataxias

(2011) Ilya Bezprozvanny   NEUROCHEMICAL RESEARCH

Role of p53 in Neurodegenerative Diseases

(2011) J. Robert Chang et al.   Neurodegenerative Diseases

Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease

(2011) Carlos A. Matos et al.   PROGRESS IN NEUROBIOLOGY

Toward understanding Machado–Joseph disease

(2011) Maria do Carmo Costa et al.   PROGRESS IN NEUROBIOLOGY

Balancing act: deubiquitinating enzymes in the nervous system

(2011) Sokol V. Todi et al.   TRENDS IN NEUROSCIENCES

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

The Machado–Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

(2010) Thomas M. Durcan et al.   HUMAN MOLECULAR GENETICS

p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons

(2010) An-Hsun Chou et al.   NEUROCHEMISTRY INTERNATIONAL

Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes

(2009) Francisca E. Reyes-Turcu et al.   Annual Review of Biochemistry

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation

(2009) Zheng Ying et al.   HUMAN MOLECULAR GENETICS

Cancer risk in association with Parkinson disease: A population-based study

(2009) Claudia Becker et al.   PARKINSONISM & RELATED DISORDERS

Calcium signaling and neurodegenerative diseases

(2009) Ilya Bezprozvanny   TRENDS IN MOLECULAR MEDICINE

The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys63Linkages in Mixed Linkage Ubiquitin Chains

(2008) Brett J. Winborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Mechanisms of a Polyglutamine-mediated Neurodegenerative Disease, Spinocerebellar Ataxia Type 1

(2008) Huda Y. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Study of subcellular localization and proteolysis of ataxin-3

(2008) Chiara Pozzi et al.   NEUROBIOLOGY OF DISEASE

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols