Regulating the stability and localization of CDK inhibitor p27Kip1via CSN6-COP1 axis

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy

(2015) Hui Zhao et al.   Oncotarget

High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle

(2015) Juan M. Caraballo et al.   Oncotarget

Effects of Obesity on Transcriptomic Changes and Cancer Hallmarks in Estrogen Receptor–Positive Breast Cancer

(2014) Enrique Fuentes-Mattei et al.   JNCI-Journal of the National Cancer Institute

CSN6 drives carcinogenesis by positively regulating Myc stability

(2014) Jian Chen et al.   Nature Communications

From photomorphogenesis to cancer

(2013) Leonardo Salmena et al.   CELL CYCLE

HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53

(2012) Yuwen Xue et al.   CELL CYCLE

CDK inhibitor p57Kip2is negatively regulated by COP9 signalosome subunit 6

(2012) Bo Chen et al.   CELL CYCLE

Aurora B kinase phosphorylates and instigates degradation of p53

(2012) C. P. Gully et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of COP9 signalosome in cancer

(2011) Mong-Hong Lee et al.   CELL CYCLE

Good COP1 or bad COP1? In vivo veritas

(2011) Wenyi Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers

(2011) Ruiying Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

(2011) Domenico Migliorini et al.   JOURNAL OF CLINICAL INVESTIGATION

COP1 is a tumour suppressor that causes degradation of ETS transcription factors

(2011) Alberto C. Vitari et al.   NATURE

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes

(2011) R Pippa et al.   ONCOGENE

COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ

(2011) H H Choi et al.   ONCOGENE

14-3-3  Exerts Tumor-Suppressor Activity Mediated by Regulation of COP1 Stability

(2010) C.-H. Su et al.   CANCER RESEARCH

Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer

(2010) Christopher P Gully et al.   Molecular Cancer

Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage

(2010) Chun-Hui Su et al.   Molecular Cancer

Roles for CSN5 in control of p53/MDM2 activities

(2007) Xiao-Chun Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY