Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells

(2017) Dongyeon Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway

(2017) Sunbin Ling et al.   Molecular Oncology

USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis

(2017) Aman Wang et al.   Frontiers in Pharmacology

Validation of tumor protein marker quantification by two independent automated immunofluorescence image analysis platforms

(2016) Amy R Peck et al.   MODERN PATHOLOGY

USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer

(2015) Haibo Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth

(2015) Ying-Li Liu et al.   GENE

USP22 promotes tumor progression and induces epithelial–mesenchymal transition in lung adenocarcinoma

(2015) Jing Hu et al.   LUNG CANCER

Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1

(2015) Zhenghong Lin et al.   Cell Discovery

USP22 Promotes NSCLC Tumorigenesis via MDMX Up-Regulation and Subsequent p53 Inhibition

(2014) Fangbao Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

(2014) Yongxing Gong et al.   NATURE GENETICS

USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells

(2014) ZHEN NING et al.   ONCOLOGY REPORTS

New Roles of Cyclin D1

(2013) Richard G. Pestell   AMERICAN JOURNAL OF PATHOLOGY

USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression

(2013) R. S. Schrecengost et al.   CANCER RESEARCH

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

(2012) Mathew C. Casimiro et al.   JOURNAL OF CLINICAL INVESTIGATION

PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS

(2012) Matthew P. Stokes et al.   MOLECULAR & CELLULAR PROTEOMICS

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

USP22 Acts as an Oncogene by the Activation of BMI-1-Mediated INK4a/ARF Pathway and Akt Pathway

(2011) Yan-Long Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A

(2011) Xiao-yong Zhang et al.   CELL CYCLE

USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1

(2011) Boyko S Atanassov et al.   EMBO REPORTS

Loss of Nuclear Localized and Tyrosine Phosphorylated Stat5 in Breast Cancer Predicts Poor Clinical Outcome and Increased Risk of Antiestrogen Therapy Failure

(2011) Amy R. Peck et al.   JOURNAL OF CLINICAL ONCOLOGY

Enzymatic assays for assessing histone deubiquitylation activity

(2011) Robyn T. Sussman et al.   METHODS

The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

(2011) G. Lang et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Phosphorylation-dependent regulation of SCFFbx4 dimerization and activity involves a novel component, 14-3-3ɛ

(2011) O Barbash et al.   ONCOGENE

SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

(2010) X D Wang et al.   CELL DEATH AND DIFFERENTIATION

Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level

(2010) Jannie M. R. Danielsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells

(2010) Lei Lv et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Suppression of Cancer Cell Growth by Promoting Cyclin D1 Degradation

(2009) Jing Shan et al.   MOLECULAR CELL

Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance

(2009) Boyko S. Atanassov et al.   MOLECULAR CELL

Crystal structure of human CDK4 in complex with a D-type cyclin

(2009) P. J. Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system

(2008) Vikki M Weake et al.   EMBO JOURNAL

GSK-3β-dependent destabilization of cyclin D1 mediates replicational stress-induced arrest of cell cycle

(2008) Atish Mukherji et al.   FEBS LETTERS

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

(2008) Xiao-Yong Zhang et al.   MOLECULAR CELL

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

(2008) Yue Zhao et al.   MOLECULAR CELL