TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment

Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease

(2021) Yue-Yu Gu et al.   Frontiers in Pharmacology

TGF-β1 Signaling: Immune Dynamics of Chronic Kidney Diseases

(2021) Philip Chiu-Tsun Tang et al.   Frontiers in Medicine

A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys

(2020) Mayur S Mitra et al.   TOXICOLOGICAL SCIENCES

Differential expression and localisation of TGF-β isoforms and receptors in the murine epididymis

(2020) Allison Voisin et al.   Scientific Reports

NK Cell Function Regulation by TGF-β-Induced Epigenetic Mechanisms

(2020) Stefano Regis et al.   Frontiers in Immunology

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

(2020) Andrew J. Gunderson et al.   Nature Communications

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage–Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor

(2020) Ángelo Torres et al.   Cells

The Emerging Role of Innate Immunity in Chronic Kidney Diseases

(2020) Philip Chiu-Tsun Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage–myofibroblast transition

(2020) Patrick Ming-Kuen Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long noncoding RNA H19X is a key mediator of TGF-β–driven fibrosis

(2020) Elena Pachera et al.   JOURNAL OF CLINICAL INVESTIGATION

DPP4/CD32b/NF-κB Circuit: A Novel Druggable Target for Inhibiting CRP-Driven Diabetic Nephropathy

(2020) Patrick Ming-Kuen Tang et al.   MOLECULAR THERAPY

Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

(2020) Vivian Weiwen Xue et al.   Cancers

Neutrophil extracellular traps promote fibrous vascular occlusions in chronic thrombosis

(2020) Smriti Sharma et al.   BLOOD

The fibrotic and immune microenvironments as targetable drivers of metastasis

(2020) Luke Boulter et al.   BRITISH JOURNAL OF CANCER

Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy

(2020) Haodi Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts

(2020) Xueke Shi et al.   Biomolecules

The double edge sword of fibrosis in cancer

(2019) Chelsea Chandler et al.   Translational Research

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC

(2019) Xing Li et al.   EXPERIMENTAL CELL RESEARCH

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

The tumor cell‐secreted matricellular protein WISP 1 drives pro‐metastatic collagen linearization

(2019) Hong Jia et al.   EMBO JOURNAL

LncRNA Erbb4‐IR promotes esophageal squamous cell carcinoma (ESCC) by downregulating miR‐145

(2019) Yan Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK

(2019) Sen Li et al.   Nutrition & Diabetes

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets

(2019) Kenneth W. Finnson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association

(2018) Justin Zonneville et al.   BMC CANCER

Knockdown of TWIST enhances the cytotoxicity of chemotherapeutic drugs in doxorubicin-resistant HepG2 cells by suppressing MDR1 and EMT

(2018) Rong Li et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Transforming growth factor-β signalling in renal fibrosis: from Smads to non-coding RNAs

(2018) Patrick Ming-Kuen Tang et al.   JOURNAL OF PHYSIOLOGY-LONDON

The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring

(2018) Patrick Ming-Kuen Tang et al.   KIDNEY INTERNATIONAL

Role of T-bet, the master regulator of Th1 cells, in the cytotoxicity of murine CD4+ T cells

(2018) Koji Eshima et al.   MICROBIOLOGY AND IMMUNOLOGY

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

(2018) Yen-An Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Teaming Up for Trouble: Cancer Cells, Transforming Growth Factor-β1 Signaling and the Epigenetic Corruption of Stromal Naïve Fibroblasts

(2018) Sergio Lamprecht et al.   Cancers

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

TGF-β receptors: In and beyond TGF-β signaling

(2018) Alexandra Vander Ark et al.   CELLULAR SIGNALLING

Bone morphogenetic protein receptor signal transduction in human diseases

(2018) Maria Catalina Gomez-Puerto et al.   JOURNAL OF PATHOLOGY

Developmental pathways in the pathogenesis of lung fibrosis

(2018) Diptiman Chanda et al.   MOLECULAR ASPECTS OF MEDICINE

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β

(2018) J. Plou et al.   Scientific Reports

Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway

(2018) Peng Wang et al.   Science Translational Medicine

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History

(2018) Or Kalchiem-Dekel et al.   Journal of Clinical Medicine

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

Transforming growth factor-β1 contributes to oxaliplatin resistance in colorectal cancer via epithelial to mesenchymal transition

(2017) Liang Mao et al.   Oncology Letters

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

(2017) Kun Zhang et al.   Nature Communications

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

(2017) Patrick Ming-Kuen Tang et al.   Nature Communications

Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells

(2017) Jun Sakata et al.   Oncotarget

Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer

(2017) Shuai Zhang et al.   Oncotarget

Silencing of TGF-β1 in tumor cells impacts MMP-9 in tumor microenvironment

(2017) Lakisha D. Moore-Smith et al.   Scientific Reports

Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients

(2017) Jijing Shi et al.   Scientific Reports

Stromal Modulators of TGF-β in Cancer

(2017) Brunella Costanza et al.   Journal of Clinical Medicine

Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways

(2016) Jiao Liu et al.   CANCER LETTERS

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

TGF-β/SMAD Pathway and Its Regulation in Hepatic Fibrosis

(2016) Fengyun Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling

(2016) Yasushi Shintani et al.   Journal of Thoracic Oncology

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI)

(2016) I García-Palmero et al.   ONCOGENE

Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance

(2016) T Yu et al.   ONCOGENE

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors

(2016) Ying Zhang et al.   Oncotarget

TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype

(2016) Fan Zhang et al.   Oncotarget

TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21

(2016) Ying Liu et al.   Scientific Reports

Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity

(2016) Shimin Wang et al.   Scientific Reports

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

(2016) J-t Cheng et al.   Oncogenesis

Mesenchymal Stem Cells Promote Pancreatic Tumor Growth by Inducing Alternative Polarization of Macrophages

(2016) Esha Mathew et al.   NEOPLASIA

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

(2015) S. Meidhof et al.   EMBO Molecular Medicine

Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma

(2015) Timothy J Underwood et al.   JOURNAL OF PATHOLOGY

Smad signal pathway regulates angiogenesis via endothelial cell in an adipose-derived stromal cell/endothelial cell co-culture, 3D gel model

(2015) Shiyu Lin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

TGF-β/Smad signaling in renal fibrosis

(2015) Xiao-Ming Meng et al.   Frontiers in Physiology

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis

(2014) J. Stanisavljevic et al.   CANCER RESEARCH

Transforming Growth Factor β-Mediated Suppression of Antitumor T Cells Requires FoxP1 Transcription Factor Expression

(2014) Tom L. Stephen et al.   IMMUNITY

Circulating mouse Flk1+/c-Kit+/CD45- cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts

(2014) Jeffery S Russell et al.   Molecular Cancer

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammatory processes in renal fibrosis

(2014) Xiao-Ming Meng et al.   Nature Reviews Nephrology

The wound healing, chronic fibrosis, and cancer progression triad

(2014) Brad Rybinski et al.   PHYSIOLOGICAL GENOMICS

Proteome Profiling of Cancer-Associated Fibroblasts Identifies Novel Proinflammatory Signatures and Prognostic Markers for Colorectal Cancer

(2013) S. Torres et al.   CLINICAL CANCER RESEARCH

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival

(2013) Tobias Hohenauer et al.   EMBO Molecular Medicine

MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

(2013) Hongping Xia et al.   HEPATOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Notch and TGF-β/Smad3 pathways are involved in the interaction between cancer cells and cancer-associated fibroblasts in papillary thyroid carcinoma

(2013) Jie Zhang et al.   TUMOR BIOLOGY

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

(2012) Ahmed F. Salem et al.   CELL CYCLE

Role of the TGF-β/BMP-7/Smad pathways in renal diseases

(2012) Xiao-Ming Meng et al.   CLINICAL SCIENCE

Fibroblast activation protein regulates tumor-associated fibroblasts and epithelial ovarian cancer cells

(2012) DONGMEI LAI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts

(2012) L J A C Hawinkels et al.   ONCOGENE

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

(2012) Anne-Pierre Morel et al.   PLoS Genetics

Colorectal Cancer Cells Activate Adjacent Fibroblasts Resulting in FGF1/FGFR3 Signaling and Increased Invasion

(2011) Maria L. Henriksson et al.   AMERICAN JOURNAL OF PATHOLOGY

ALK1 as an emerging target for antiangiogenic therapy of cancer

(2011) S. I. Cunha et al.   BLOOD

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

(2011) Hyung-Ok Lee et al.   BMC CANCER

Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

(2011) Tuanjie Li et al.   CANCER LETTERS

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

Targeting Galectin-1 in Carcinoma-Associated Fibroblasts Inhibits Oral Squamous Cell Carcinoma Metastasis by Downregulating MCP-1/CCL2 Expression

(2011) Ming-Heng Wu et al.   CLINICAL CANCER RESEARCH

Role of TGF-β and the Tumor Microenvironment During Mammary Tumorigenesis

(2011) MOLLY A. TAYLOR et al.   GENE EXPRESSION

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro

(2011) Xiao-Ming Meng et al.   KIDNEY INTERNATIONAL

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth

(2011) T J Standiford et al.   ONCOGENE

Smad2 Protects against TGF- /Smad3-Mediated Renal Fibrosis

(2010) X. M. Meng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of stromal myofibroblasts in invasive breast cancer: stromal expression of alpha-smooth muscle actin correlates with worse clinical outcome

(2010) Masako Yamashita et al.   Breast Cancer

The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis

(2009) Nicole Reich et al.   ARTHRITIS AND RHEUMATISM

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer

(2009) Christine A. Iacobuzio-Donahue et al.   JOURNAL OF CLINICAL ONCOLOGY

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

(2009) Jyoti Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Down-regulation of Gfi-1 expression by TGF-β is important for differentiation of Th17 and CD103+inducible regulatory T cells

(2009) Jinfang Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

(2009) M. Balsamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Transforming growth factor-β1 is the predominant isoform required for breast cancer cell outgrowth in bone

(2008) A A Mourskaia et al.   ONCOGENE

Arkadia regulates TGF-β signaling during renal tubular epithelial to mesenchymal cell transition

(2007) F.-Y. Liu et al.   KIDNEY INTERNATIONAL