Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy
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Title
Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy
Authors
Keywords
TGF-β signaling, Tumor microenvironment, Immune cells, TGF-β inhibitors
Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 89, Issue -, Pages 107101
Publisher
Elsevier BV
Online
2020-10-21
DOI
10.1016/j.intimp.2020.107101
References
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Note: Only part of the references are listed.- Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances
- (2020) Hanne Lind et al. Journal for ImmunoTherapy of Cancer
- Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial
- (2020) Luis Paz-Ares et al. Journal of Thoracic Oncology
- Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
- (2020) Constance J. Martin et al. Science Translational Medicine
- TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering
- (2020) Jin Ma et al. Frontiers in Cell and Developmental Biology
- Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition
- (2019) Yoko Katsuno et al. Science Signaling
- Specificity, versatility, and control of TGF-β family signaling
- (2019) Rik Derynck et al. Science Signaling
- TGFβ receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer
- (2019) Davide Melisi et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- A Phase 2 Study of Galunisertib (TGF-β1 Receptor Type I Inhibitor) and Sorafenib in Patients With Advanced Hepatocellular Carcinoma
- (2019) R.K. Kelley et al. Clinical and Translational Gastroenterology
- Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment
- (2019) Yoshiro Itatani et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors
- (2018) Julius Strauss et al. CLINICAL CANCER RESEARCH
- The role of TGF-β/SMAD4 signaling in cancer
- (2018) Ming Zhao et al. International Journal of Biological Sciences
- TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
- (2018) Daniele V. F. Tauriello et al. NATURE
- Contextual determinants of TGFβ action in development, immunity and cancer
- (2018) Charles J. David et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Impact of targeting transforming growth factor β-2 with antisense OT-101 on the cytokine and chemokine profile in patients with advanced pancreatic cancer
- (2018) Osmond D'Cruz et al. OncoTargets and Therapy
- Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
- (2018) Rajani Ravi et al. Nature Communications
- M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine
- (2018) Karin M. Knudson et al. OncoImmunology
- Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
- (2018) Rikke B. Holmgaard et al. Journal for ImmunoTherapy of Cancer
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells
- (2017) Ana Rodríguez-García et al. FEBS Journal
- Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer
- (2016) Alessandra Metelli et al. CANCER RESEARCH
- TGF-β Tumor Suppression through a Lethal EMT
- (2016) Charles J. David et al. CELL
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads
- (2016) Apirat Chaikuad et al. Cold Spring Harbor Perspectives in Biology
- TGF-β Family Signaling in the Control of Cell Proliferation and Survival
- (2016) Yun Zhang et al. Cold Spring Harbor Perspectives in Biology
- Novel TGF-β inhibitors ready for prime time in onco-immunology
- (2016) Armand de Gramont et al. OncoImmunology
- A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer
- (2015) G. Giaccone et al. EUROPEAN JOURNAL OF CANCER
- TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression
- (2015) Hou-Pu Liu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Belagenpumatucel-L for the treatment of non-small cell lung cancer
- (2015) Erika Rijavec et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Targeting the TGFβ pathway for cancer therapy
- (2015) Cindy Neuzillet et al. PHARMACOLOGY & THERAPEUTICS
- Trimodal Glioblastoma Treatment Consisting of Concurrent Radiotherapy, Temozolomide, and the Novel TGF-β Receptor I Kinase Inhibitor LY2109761
- (2015) Mengxian Zhang et al. NEOPLASIA
- Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study
- (2014) Richard J. Kovacs et al. Cardiovascular Toxicology
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma
- (2014) John C. Morris et al. PLoS One
- Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-
- (2014) Z. Wiener et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells
- (2014) Xiangxuan Zhao et al. Protein & Cell
- Evaluation of antitumor activity of a TGF-beta receptor I inhibitor (SD-208) on human colon adenocarcinoma
- (2014) Abolfazl Akbari et al. DARU-Journal of Pharmaceutical Sciences
- Inhibition of the mTOR pathway: A possible protective role in coronary artery disease
- (2013) Giovanni Tarantino et al. ANNALS OF MEDICINE
- TGF-β Activation and Function in Immunity
- (2013) Mark A. Travis et al. Annual Review of Immunology
- Defining a therapeutic window for the novel TGF-β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model
- (2013) Ivelina Gueorguieva et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Rapamycin Inhibits Transforming Growth Factor β1-Induced Fibrogenesis in Primary Human Lung Fibroblasts
- (2013) Yu Gao et al. YONSEI MEDICAL JOURNAL
- Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling
- (2013) B. R. Achyut et al. PLoS Genetics
- TGF-β signalling and its role in cancer progression and metastasis
- (2012) Yvette Drabsch et al. CANCER AND METASTASIS REVIEWS
- TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
- (2012) S. Lamouille et al. JOURNAL OF CELL SCIENCE
- GARP regulates the bioavailability and activation of TGFβ
- (2012) Rui Wang et al. MOLECULAR BIOLOGY OF THE CELL
- Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer
- (2011) Karl-Hermann Schlingensiepen et al. CANCER SCIENCE
- A Poised Chromatin Platform for TGF-β Access to Master Regulators
- (2011) Qiaoran Xi et al. CELL
- Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression
- (2011) Michael K. Wendt et al. CELL AND TISSUE RESEARCH
- Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options
- (2011) Giuseppe Pignataro et al. CURRENT OPINION IN PHARMACOLOGY
- Latent TGF-β structure and activation
- (2011) Minlong Shi et al. NATURE
- Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
- (2011) Mark J. Anderton et al. TOXICOLOGIC PATHOLOGY
- Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development
- (2010) Weiming Ouyang et al. IMMUNITY
- Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study
- (2010) U. Bogdahn et al. NEURO-ONCOLOGY
- TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
- (2010) Li Yang et al. TRENDS IN IMMUNOLOGY
- TGF-β induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL
- (2009) L C Spender et al. CELL DEATH AND DIFFERENTIATION
- Inhibition of transforming growth factor β receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation
- (2009) Antonio Mazzocca et al. HEPATOLOGY
- Changes in expression, and/or mutations in TGF-β receptors (TGF-β RI and TGF-β RII) and Smad 4 in human ovarian tumors
- (2009) Marie Lue Antony et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Diffuse-Type Gastric Carcinoma: Progression, Angiogenesis, and Transforming Growth Factor β Signaling
- (2009) Akiyoshi Komuro et al. JNCI-Journal of the National Cancer Institute
- TGF- and 'Adaptive' Foxp3+ Regulatory T cells
- (2009) W. Chen et al. Journal of Molecular Cell Biology
- Roles of TGFβ in metastasis
- (2008) David Padua et al. CELL RESEARCH
- Modeling and analysis of MH1 domain of Smads and their interaction with promoter DNA sequence motif
- (2008) Pooja Makkar et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
- (2008) Liang Zhou et al. NATURE
- A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
- (2008) Yongzhong Liu et al. NATURE IMMUNOLOGY
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