The Antidiabetic Drug Metformin Stimulates Glycolytic Lactate Production in Cultured Primary Rat Astrocytes

Adverse event notifications implicating metformin with lactic acidosis in Australia

(2015) Weiyi Huang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1

(2015) Mark F. McCarty et al.   MEDICAL HYPOTHESES

Evidence for organic cation transporter-mediated metformin transport and 5′-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles

(2015) Rieko Oshima et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting Adenosine Monophosphate-Activated Protein Kinase by Metformin Adjusts Post-Ischemic Hyperemia and Extracellular Neuronal Discharge in Transient Global Cerebral Ischemia

(2015) Yaghoob Farbood et al.   MICROCIRCULATION

Role of organic cation transporters (OCTs) in the brain

(2015) Thomas Couroussé et al.   PHARMACOLOGY & THERAPEUTICS

Natural Products for the Treatment of Type 2 Diabetes Mellitus

(2015) José Ríos et al.   PLANTA MEDICA

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

(2015) Lacey M. Litchfield et al.   Oncotarget

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS

(2015) Bettina Schreiner et al.   Cell Reports

Roles and Regulation of Ketogenesis in Cultured Astroglia and Neurons Under Hypoxia and Hypoglycemia

(2014) Shinichi Takahashi et al.   ASN Neuro

The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

(2014) Stefania Orecchioni et al.   INTERNATIONAL JOURNAL OF CANCER

Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins:in vitroandin vivostudies

(2014) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROCHEMISTRY

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Glutathione-Dependent Detoxification Processes in Astrocytes

(2014) Ralf Dringen et al.   NEUROCHEMICAL RESEARCH

Arsenite stimulates glutathione export and glycolytic flux in viable primary rat brain astrocytes

(2014) Nimesha Tadepalle et al.   NEUROCHEMISTRY INTERNATIONAL

Mortality rate in so-called “metformin-associated lactic acidosis”: a review of the data since the 1960s

(2014) Farshad Kajbaf et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Astrocytes revisited: concise historic outlook on glutamate homeostasis and signaling

(2013) Vladimir Parpura et al.   CROATIAN MEDICAL JOURNAL

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

8-Hydroxy-efavirenz, the Primary Metabolite of the Antiretroviral Drug Efavirenz, Stimulates the Glycolytic Flux in Cultured Rat Astrocytes

(2013) Maria Brandmann et al.   NEUROCHEMICAL RESEARCH

Comparison of Primary and Secondary Rat Astrocyte Cultures Regarding Glucose and Glutathione Metabolism and the Accumulation of Iron Oxide Nanoparticles

(2013) Charlotte Petters et al.   NEUROCHEMICAL RESEARCH

The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis

(2013) Farshad Kajbaf et al.   BMC Pharmacology & Toxicology

In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism

(2012) Claudia Carducci et al.   BMC NEUROSCIENCE

Formate generated by cellular oxidation of formaldehyde accelerates the glycolytic flux in cultured astrocytes

(2012) Ketki Tulpule et al.   GLIA

Astrocyte functions in the copper homeostasis of the brain

(2012) Ivo F. Scheiber et al.   NEUROCHEMISTRY INTERNATIONAL

Metformin pathways

(2012) Li Gong et al.   Pharmacogenetics and Genomics

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Accumulation of silver nanoparticles by cultured primary brain astrocytes

(2011) Eva M Luther et al.   NANOTECHNOLOGY

Copper Accelerates Glycolytic Flux in Cultured Astrocytes

(2011) Ivo F. Scheiber et al.   NEUROCHEMICAL RESEARCH

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)

(2011) Anne T. Nies et al.   PLoS One

Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGFβ1 regulation

(2010) Martin N Stienen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of Chlorinated Acetates on the Glutathione Metabolism and on Glycolysis of Cultured Astrocytes

(2010) Maike M. Schmidt et al.   NEUROTOXICITY RESEARCH

The cytosolic redox state of astrocytes: Maintenance, regulation and functional implications for metabolite trafficking

(2009) Johannes Hirrlinger et al.   BRAIN RESEARCH REVIEWS

Use of Protein Tyrosine Phosphatase Inhibitors as Promising Targeted Therapeutic Drugs

(2009) P. Heneberg   CURRENT MEDICINAL CHEMISTRY

Mysterious Metformin

(2009) C. R. Chong et al.   ONCOLOGIST

Metformin therapy and clinical uses

(2008) John HB Scarpello et al.   Diabetes & Vascular Disease Research

Proton pump inhibitors: an update of their clinical use and pharmacokinetics

(2008) Shaojun Shi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY