PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Autophagy in Premature Senescent Cells Is Activated via AMPK Pathway

(2012) Liujing Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Delayed hyperbaric oxygen therapy induces cell proliferation through stabilization of cAMP responsive element binding protein in the rat model of MCAo-induced ischemic brain injury

(2012) Jun Mu et al.   NEUROBIOLOGY OF DISEASE

mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development

(2012) H Peng et al.   ONCOGENE

Transcriptional Control of Cellular Metabolism by mTOR Signaling

(2011) J. L. Yecies et al.   CANCER RESEARCH

Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling

(2011) Jianhui Ma et al.   Journal of Genetics and Genomics

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

(2011) Min Zheng et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of dichloroacetate in the treatment of genetic mitochondrial diseases☆

(2008) Peter W. Stacpoole et al.   ADVANCED DRUG DELIVERY REVIEWS

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF6 -Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

(2008) D. M. Schewe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA