Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension

(2016) Lydie Plecitá-Hlavatá et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

(2015) Nazzareno Galiè et al.   EUROPEAN HEART JOURNAL

A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors

(2015) Quincy Siu-Chung Chu et al.   INVESTIGATIONAL NEW DRUGS

Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension

(2015) Kurt R. Stenmark et al.   JOURNAL OF APPLIED PHYSIOLOGY

UCP2 modulates single-channel properties of a MCU-dependent Ca2+ inward current in mitochondria

(2015) Alexander I. Bondarenko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans

(2014) Roxane Paulin et al.   Cell Metabolism

The Metabolic Basis of Pulmonary Arterial Hypertension

(2014) Gopinath Sutendra et al.   Cell Metabolism

The Metabolic Theory of Pulmonary Arterial Hypertension

(2014) Roxane Paulin et al.   CIRCULATION RESEARCH

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Tyr-301 Phosphorylation Inhibits Pyruvate Dehydrogenase by Blocking Substrate Binding and Promotes the Warburg Effect

(2014) Jun Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Hyperpolarization in Pulmonary Vascular Remodeling. Mitochondrial Uncoupling Protein Deficiency as Disease Model

(2013) Oleg Pak et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Heterogeneity in Lung 18 FDG Uptake in Pulmonary Arterial Hypertension

(2013) Lan Zhao et al.   CIRCULATION

Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Remodeling and Pulmonary Hypertension

(2013) Peter Dromparis et al.   CIRCULATION RESEARCH

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

(2013) E. M. Dunbar et al.   INVESTIGATIONAL NEW DRUGS

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

(2013) Shih-Chia Tso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term safety of dichloroacetate in congenital lactic acidosis

(2013) Monica Abdelmalak et al.   MOLECULAR GENETICS AND METABOLISM

Pulmonary Arterial Hypertension: Challenges in Translational Research and a Vision for Change

(2013) G. Sutendra et al.   Science Translational Medicine

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

(2013) Gopinath Sutendra et al.   Frontiers in Oncology

Mitochondria in Vascular Health and Disease

(2012) Peter Dromparis et al.   Annual Review of Physiology

Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

(2012) G Sutendra et al.   ONCOGENE

Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate

(2011) Albert L. Shroads et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension

(2011) Gopinath Sutendra et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

The Role of Nogo and the Mitochondria-Endoplasmic Reticulum Unit in Pulmonary Hypertension

(2011) G. Sutendra et al.   Science Translational Medicine

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension

(2009) et al.   CIRCULATION

Mendelian Randomization

(2009) George Thanassoulis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

(2009) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of dichloroacetate in the treatment of genetic mitochondrial diseases☆

(2008) Peter W. Stacpoole et al.   ADVANCED DRUG DELIVERY REVIEWS

Insulin resistance in pulmonary arterial hypertension

(2008) R. T. Zamanian et al.   EUROPEAN RESPIRATORY JOURNAL

A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted

(2008) Jayan Nagendran et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

(2008) Christos S. Karapetis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of Long-term Treatment of Children With Congenital Lactic Acidosis With Dichloroacetate

(2008) P. W. Stacpoole et al.   PEDIATRICS