Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions

Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer

(2016) Yang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy

(2015) Helena Pópulo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The role of intravitreal chemotherapy for retinoblastoma

(2015) CarolL Shields et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors

(2015) Quincy Siu-Chung Chu et al.   INVESTIGATIONAL NEW DRUGS

Pathological glycogenesis through glycogen synthase 1 and suppression of excessive AMP kinase activity in myeloid leukemia cells

(2015) H Bhanot et al.   LEUKEMIA

Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies

(2013) Diane E Rushlow et al.   LANCET ONCOLOGY

Hypoxic tumor microenvironment in advanced retinoblastoma

(2013) Job Sudhakar et al.   PEDIATRIC BLOOD & CANCER

RNAi Mediated Tiam1 Gene Knockdown Inhibits Invasion of Retinoblastoma

(2013) Nithya Subramanian et al.   PLoS One

Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling

(2013) F Gong et al.   Cell Death & Disease

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

(2013) Gopinath Sutendra et al.   Frontiers in Oncology

Molecular Pathways: Regulation of Metabolism by RB

(2012) B. F. Clem et al.   CLINICAL CANCER RESEARCH

Retinoblastoma

(2012) Helen Dimaras et al.   LANCET

Overexpression of Pyruvate Dehydrogenase Kinase 3 Increases Drug Resistance and Early Recurrence in Colon Cancer

(2011) Chun-Wun Lu et al.   AMERICAN JOURNAL OF PATHOLOGY

The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity

(2011) M M Reddy et al.   LEUKEMIA

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

(2010) B M Madhok et al.   BRITISH JOURNAL OF CANCER

NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases

(2010) M M Reddy et al.   LEUKEMIA

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

(2008) S M Wigfield et al.   BRITISH JOURNAL OF CANCER

Dichloroacetate induces apoptosis in endometrial cancer cells

(2008) Jason Y.Y. Wong et al.   GYNECOLOGIC ONCOLOGY

Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma

(2008) Helen Dimaras et al.   HUMAN MOLECULAR GENETICS

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance

(2008) Chun-Wun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dichloroacetate (DCA) sensitizes both wild‐type and over expressingBcl‐2prostate cancer cells in vitro to radiation

(2008) Wengang Cao et al.   PROSTATE

Insights from mouse models into human retinoblastoma

(2008) David MacPherson   Cell Division